CO6630197A2 - Nuevos procesos - Google Patents

Nuevos procesos

Info

Publication number
CO6630197A2
CO6630197A2 CO12208170A CO12208170A CO6630197A2 CO 6630197 A2 CO6630197 A2 CO 6630197A2 CO 12208170 A CO12208170 A CO 12208170A CO 12208170 A CO12208170 A CO 12208170A CO 6630197 A2 CO6630197 A2 CO 6630197A2
Authority
CO
Colombia
Prior art keywords
atherosclerosis
new process
vascular
primary
useful
Prior art date
Application number
CO12208170A
Other languages
English (en)
Inventor
Kevin Stuart Cardwell
Claire Frances Crawford
Suzanne Helen Davies
Charles Edward Wade
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44992024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6630197(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CO6630197A2 publication Critical patent/CO6630197A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La siguiente invención proporciona métodos y procesos para la preparación de compuestos de pirimidona de Formula (I)e intermediarios de síntesis del mismo, los cuales son útiles para tratar enfermedades cardiovasculares e inflamatorias tales como aterosclerosis, así como tiene utilidad en la prevención primaria y secundaria de eventos coronarios agudos, por ejemplo los provocados por aterosclerosis, incluyendo aterosclerosis vascular periférica y aterosclerosis cerebro vascular.
CO12208170A 2010-05-17 2012-11-16 Nuevos procesos CO6630197A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34522410P 2010-05-17 2010-05-17

Publications (1)

Publication Number Publication Date
CO6630197A2 true CO6630197A2 (es) 2013-03-01

Family

ID=44992024

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12208170A CO6630197A2 (es) 2010-05-17 2012-11-16 Nuevos procesos

Country Status (24)

Country Link
US (2) US9447052B2 (es)
EP (1) EP2571857B1 (es)
JP (1) JP6027529B2 (es)
KR (1) KR20130089157A (es)
CN (2) CN105837520A (es)
AR (1) AR081399A1 (es)
AU (1) AU2011256270B2 (es)
BR (1) BR112012030532A2 (es)
CA (1) CA2799520C (es)
CL (1) CL2012003206A1 (es)
CO (1) CO6630197A2 (es)
CR (1) CR20120630A (es)
DO (1) DOP2012000289A (es)
EA (1) EA026569B1 (es)
IL (1) IL223068A0 (es)
MA (1) MA34301B1 (es)
MX (1) MX2012013387A (es)
NZ (1) NZ603672A (es)
PE (1) PE20130318A1 (es)
SG (1) SG185559A1 (es)
TW (1) TW201209043A (es)
UY (1) UY33388A (es)
WO (1) WO2011146494A1 (es)
ZA (1) ZA201208631B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33388A (es) * 2010-05-17 2011-12-01 Glaxo Group Ltd Nuevos procesos para la preparacion de compuestos de pirimidinona
WO2015087239A1 (en) 2013-12-11 2015-06-18 Ranbaxy Laboratories Limited Processes for the preparation of darapladib and its intermediates
WO2015092687A2 (en) 2013-12-17 2015-06-25 Ranbaxy Laboratories Limited Process for the purification of darapladib
US11583596B2 (en) 2017-09-26 2023-02-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Radiolabeled Darapladib and analogs thereof and their use as imaging compounds
US10866963B2 (en) * 2017-12-28 2020-12-15 Dropbox, Inc. File system authentication

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1143516B (de) * 1961-04-27 1963-02-14 Bayer Ag Verfahren zur Herstellung von Peptiden
US4277465A (en) 1978-08-26 1981-07-07 Kyoto Yakuhin Kogyo Kabushiki Kaisha Adjuvant for promoting absorption of therapeutically active substances through the digestive tract
US4235776A (en) * 1979-03-15 1980-11-25 Eli Lilly And Company Tetrahydro-2H-benzo[c]pyrroles
DE2941597A1 (de) * 1979-10-13 1981-04-23 Basf Ag, 6700 Ludwigshafen Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4619941A (en) * 1984-11-19 1986-10-28 American Cyanamid Company N-[(1H-imidazol-1-yl)alkyl]-1H-indolecarboxamides useful as thromboxane synthetase inhibitors and antihypertensive agents
ES2203988T3 (es) 1997-11-06 2004-04-16 Smithkline Beecham Plc Compuestos de pirimidinona y composiciones farmaceuticas que los contienen.
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
AU1520300A (en) 1998-11-05 2000-05-29 Biocryst Pharmaceuticals, Inc. New cyclopentane and cyclopentene compounds and use for detecting influenza virus
SI1175408T1 (en) 1999-05-01 2005-04-30 Smithkline Beecham Plc Pyrimidinone compounds
ATE437862T1 (de) * 2000-02-16 2009-08-15 Smithkline Beecham Plc Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
GB0119795D0 (en) 2001-08-14 2001-10-03 Smithkline Beecham Plc Novel process
UY33388A (es) * 2010-05-17 2011-12-01 Glaxo Group Ltd Nuevos procesos para la preparacion de compuestos de pirimidinona

Also Published As

Publication number Publication date
EA201291235A1 (ru) 2013-04-30
AR081399A1 (es) 2012-08-29
EA026569B1 (ru) 2017-04-28
EP2571857A4 (en) 2013-11-20
MX2012013387A (es) 2012-12-10
KR20130089157A (ko) 2013-08-09
DOP2012000289A (es) 2013-04-15
IL223068A0 (en) 2013-02-03
CA2799520C (en) 2016-09-13
AU2011256270B2 (en) 2015-11-26
TW201209043A (en) 2012-03-01
WO2011146494A1 (en) 2011-11-24
AU2011256270A1 (en) 2012-12-20
JP6027529B2 (ja) 2016-11-16
PE20130318A1 (es) 2013-04-11
EP2571857A1 (en) 2013-03-27
CL2012003206A1 (es) 2013-01-25
CN105837520A (zh) 2016-08-10
SG185559A1 (en) 2012-12-28
EP2571857B1 (en) 2017-08-23
CN103003249B (zh) 2016-04-27
US9447052B2 (en) 2016-09-20
US20160347720A1 (en) 2016-12-01
BR112012030532A2 (pt) 2015-09-29
CN103003249A (zh) 2013-03-27
NZ603672A (en) 2015-01-30
ZA201208631B (en) 2013-09-25
JP2013530948A (ja) 2013-08-01
CA2799520A1 (en) 2011-11-24
MA34301B1 (fr) 2013-06-01
US9725420B2 (en) 2017-08-08
US20130060028A1 (en) 2013-03-07
CR20120630A (es) 2013-02-15
UY33388A (es) 2011-12-01

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