MA35034B1 - Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires - Google Patents
Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediairesInfo
- Publication number
- MA35034B1 MA35034B1 MA36321A MA36321A MA35034B1 MA 35034 B1 MA35034 B1 MA 35034B1 MA 36321 A MA36321 A MA 36321A MA 36321 A MA36321 A MA 36321A MA 35034 B1 MA35034 B1 MA 35034B1
- Authority
- MA
- Morocco
- Prior art keywords
- pepsipeptides
- methods
- novel intermediates
- preparing macrocyclic
- macrocyclic
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cookers (AREA)
- Cereal-Derived Products (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne une méthode ou un procédé de préparation chimique de depsipeptides de formule (I), les symboles présentant la signification définie dans la description, de nouveaux intermédiaires et leur préparation ainsi que des modes de réalisation de l'invention associés.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161477319P | 2011-04-20 | 2011-04-20 | |
PCT/IB2012/051977 WO2012143888A1 (fr) | 2011-04-20 | 2012-04-19 | Procédés de préparation de depsipeptides macrocycliques et nouveaux intermédiaires |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35034B1 true MA35034B1 (fr) | 2014-04-03 |
Family
ID=46317455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36321A MA35034B1 (fr) | 2011-04-20 | 2012-04-19 | Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires |
Country Status (21)
Country | Link |
---|---|
US (2) | US8614289B2 (fr) |
EP (1) | EP2699585A1 (fr) |
JP (2) | JP5951006B2 (fr) |
KR (1) | KR101580729B1 (fr) |
CN (2) | CN104804072A (fr) |
AR (1) | AR086168A1 (fr) |
AU (1) | AU2012245980B2 (fr) |
BR (1) | BR112013026660A2 (fr) |
CA (1) | CA2833109A1 (fr) |
CL (2) | CL2013003037A1 (fr) |
CO (1) | CO6801799A2 (fr) |
EA (2) | EA201500734A1 (fr) |
GT (1) | GT201300256A (fr) |
IL (1) | IL228727A0 (fr) |
MA (1) | MA35034B1 (fr) |
MX (1) | MX337526B (fr) |
PE (1) | PE20141206A1 (fr) |
SG (1) | SG193918A1 (fr) |
TN (1) | TN2013000385A1 (fr) |
TW (1) | TW201249863A (fr) |
WO (1) | WO2012143888A1 (fr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103298827B (zh) | 2007-08-17 | 2017-05-31 | 诺华股份有限公司 | 环状酯肽 |
US8614289B2 (en) | 2011-04-20 | 2013-12-24 | Novartis Ag | Processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US20170022254A1 (en) | 2014-04-08 | 2017-01-26 | Novartis Ag | Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates |
EP3298027B1 (fr) * | 2015-05-20 | 2021-04-28 | Boehringer Ingelheim Animal Health USA Inc. | Composés depsipeptidiques anthelminthiques |
CN108290923A (zh) | 2015-09-17 | 2018-07-17 | 麻省理工学院 | 用于固相肽合成的方法和系统 |
KR102031186B1 (ko) * | 2017-01-11 | 2019-11-08 | 주식회사 엘지생활건강 | 단백질 강도 강화용 조성물 |
US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3043252C2 (de) | 1980-11-15 | 1982-12-02 | Degussa Ag, 6000 Frankfurt | Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung |
US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
DE4421113A1 (de) | 1994-06-16 | 1995-12-21 | Biotechnolog Forschung Gmbh | Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung |
DE19828043A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
JP2000154198A (ja) | 1998-11-20 | 2000-06-06 | Nisshin Flour Milling Co Ltd | 環状デプシペプチドの固相合成方法及びその中間体 |
GB0108234D0 (en) * | 2001-04-02 | 2001-05-23 | Pharma Mar Sa | Process for producing trunkamide A compounds |
US20040110228A1 (en) | 2002-04-01 | 2004-06-10 | Mcalpine Shelli R. | Combinatorial organic synthesis of unique biologically active compounds |
ES2341545T3 (es) | 2003-06-06 | 2010-06-22 | Arexis Ab | Uso de compuestos heterociclicos condensados como inhibidores de scce para el tratamiento de enfermedades de la piel. |
GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
WO2005075667A1 (fr) | 2004-02-03 | 2005-08-18 | Bayer Healthcare Ag | Methodes de diagnostic et de traitement de maladies associees a la kallikreine 7 (klk7) |
EP1994181A4 (fr) | 2006-02-27 | 2010-05-19 | Univ Arizona | Identification et utilisation de novopeptides pour le traitement du cancer |
GB0715750D0 (en) | 2007-08-13 | 2007-09-19 | Karus Therapeutics Ltd | Chemical compounds |
EP2183270B1 (fr) | 2007-08-17 | 2014-12-17 | Novartis AG | Utilisation de dépsipeptides cycliques pour inhiber la kallikréine 7 |
CN103298827B (zh) * | 2007-08-17 | 2017-05-31 | 诺华股份有限公司 | 环状酯肽 |
DE102007052391A1 (de) | 2007-10-31 | 2009-05-07 | Henkel Ag & Co. Kgaa | Mattwachs |
US20110112121A1 (en) | 2009-07-06 | 2011-05-12 | Joerg Berghausen | Pharmaceutical Compositions and Solid Forms |
KR101004362B1 (ko) | 2010-03-19 | 2010-12-28 | 가톨릭대학교 산학협력단 | 자가 면역 질환 예방 및 치료용 TNF-α와 TWEAK 이중 길항제 |
US20120064136A1 (en) | 2010-09-10 | 2012-03-15 | Nanobio Corporation | Anti-aging and wrinkle treatment methods using nanoemulsion compositions |
EP2616037A2 (fr) | 2010-09-14 | 2013-07-24 | Trima - Israel Phramaceutical Products Maabarot Ltd. | Composition topique moussante |
EP3689331A1 (fr) | 2011-01-24 | 2020-08-05 | Anterios, Inc. | Compositions de nanoparticules, leurs formulations et utilisations |
KR20140003572A (ko) | 2011-01-24 | 2014-01-09 | 안테리오스, 인코퍼레이티드 | 나노입자 조성물 |
US8614289B2 (en) | 2011-04-20 | 2013-12-24 | Novartis Ag | Processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
US20170022254A1 (en) | 2014-04-08 | 2017-01-26 | Novartis Ag | Novel Aldehyde Acetal Based Processes for the Manufacture of Macrocyclic Depsipeptides and New Intermediates |
-
2012
- 2012-04-18 US US13/449,937 patent/US8614289B2/en not_active Expired - Fee Related
- 2012-04-18 AR ARP120101326A patent/AR086168A1/es unknown
- 2012-04-19 EP EP12727933.9A patent/EP2699585A1/fr not_active Withdrawn
- 2012-04-19 WO PCT/IB2012/051977 patent/WO2012143888A1/fr active Application Filing
- 2012-04-19 KR KR1020137030625A patent/KR101580729B1/ko not_active IP Right Cessation
- 2012-04-19 CN CN201510232322.3A patent/CN104804072A/zh active Pending
- 2012-04-19 MA MA36321A patent/MA35034B1/fr unknown
- 2012-04-19 PE PE2013002370A patent/PE20141206A1/es not_active Application Discontinuation
- 2012-04-19 MX MX2013012188A patent/MX337526B/es active IP Right Grant
- 2012-04-19 EA EA201500734A patent/EA201500734A1/ru unknown
- 2012-04-19 EA EA201391554A patent/EA025546B1/ru not_active IP Right Cessation
- 2012-04-19 SG SG2013070453A patent/SG193918A1/en unknown
- 2012-04-19 AU AU2012245980A patent/AU2012245980B2/en not_active Ceased
- 2012-04-19 TW TW101114027A patent/TW201249863A/zh unknown
- 2012-04-19 BR BR112013026660A patent/BR112013026660A2/pt not_active IP Right Cessation
- 2012-04-19 CN CN201280019062.6A patent/CN103476789B/zh not_active Expired - Fee Related
- 2012-04-19 JP JP2014505772A patent/JP5951006B2/ja not_active Expired - Fee Related
- 2012-04-19 CA CA2833109A patent/CA2833109A1/fr not_active Abandoned
-
2013
- 2013-09-25 TN TNP2013000385A patent/TN2013000385A1/fr unknown
- 2013-10-03 IL IL228727A patent/IL228727A0/en unknown
- 2013-10-18 CL CL2013003037A patent/CL2013003037A1/es unknown
- 2013-10-18 GT GT201300256A patent/GT201300256A/es unknown
- 2013-10-24 CO CO13252979A patent/CO6801799A2/es unknown
- 2013-11-18 US US14/082,315 patent/US9278997B2/en active Active
-
2015
- 2015-03-18 CL CL2015000688A patent/CL2015000688A1/es unknown
-
2016
- 2016-03-07 JP JP2016043330A patent/JP2016164158A/ja active Pending
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