EA201391267A1 - Способ получения органических соединений - Google Patents

Способ получения органических соединений

Info

Publication number
EA201391267A1
EA201391267A1 EA201391267A EA201391267A EA201391267A1 EA 201391267 A1 EA201391267 A1 EA 201391267A1 EA 201391267 A EA201391267 A EA 201391267A EA 201391267 A EA201391267 A EA 201391267A EA 201391267 A1 EA201391267 A1 EA 201391267A1
Authority
EA
Eurasian Patent Office
Prior art keywords
organic compounds
obtaining organic
preparation
intermediates
obtaining
Prior art date
Application number
EA201391267A
Other languages
English (en)
Other versions
EA025381B1 (ru
Inventor
Бернхард Эрб
Изабель Силвье Галлу
Флориан Карл Кляйнбек
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45787206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201391267(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201391267A1 publication Critical patent/EA201391267A1/ru
Publication of EA025381B1 publication Critical patent/EA025381B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Предусмотрен способ получения и промежуточные соединения для получения производных 2-карбоксамид циклоамино мочевины формулы (X), а также их полезные промежуточные соединения.
EA201391267A 2011-03-03 2012-03-01 Способ и промежуточные соединения, полезные для получения производных 2-карбоксамид циклоаминомочевины EA025381B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161448774P 2011-03-03 2011-03-03
PCT/EP2012/053559 WO2012117071A1 (en) 2011-03-03 2012-03-01 Synthesis of 2-carboxamide cycloamino urea derivatives

Publications (2)

Publication Number Publication Date
EA201391267A1 true EA201391267A1 (ru) 2014-01-30
EA025381B1 EA025381B1 (ru) 2016-12-30

Family

ID=45787206

Family Applications (4)

Application Number Title Priority Date Filing Date
EA201792068A EA032802B1 (ru) 2011-03-03 2012-03-01 Производное пиридина, пригодное для синтеза ингибитора pi3k
EA201691331A EA201691331A1 (ru) 2011-03-03 2012-03-01 Способ получения органических соединений
EA201892052A EA201892052A1 (ru) 2011-03-03 2012-03-01 Способ получения органических соединений
EA201391267A EA025381B1 (ru) 2011-03-03 2012-03-01 Способ и промежуточные соединения, полезные для получения производных 2-карбоксамид циклоаминомочевины

Family Applications Before (3)

Application Number Title Priority Date Filing Date
EA201792068A EA032802B1 (ru) 2011-03-03 2012-03-01 Производное пиридина, пригодное для синтеза ингибитора pi3k
EA201691331A EA201691331A1 (ru) 2011-03-03 2012-03-01 Способ получения органических соединений
EA201892052A EA201892052A1 (ru) 2011-03-03 2012-03-01 Способ получения органических соединений

Country Status (32)

Country Link
US (3) US9650373B2 (ru)
EP (1) EP2681192B1 (ru)
JP (1) JP6022485B2 (ru)
KR (1) KR101851421B1 (ru)
CN (2) CN103402982B (ru)
AR (2) AR088714A1 (ru)
AU (1) AU2012222346B2 (ru)
BR (1) BR112013021882A2 (ru)
CA (1) CA2828509C (ru)
CL (1) CL2013002521A1 (ru)
CO (1) CO6751286A2 (ru)
DK (1) DK2681192T3 (ru)
EA (4) EA032802B1 (ru)
EC (1) ECSP13012914A (ru)
ES (1) ES2663717T3 (ru)
GT (1) GT201300211A (ru)
HU (1) HUE036319T2 (ru)
IL (1) IL228023A (ru)
MA (1) MA34982B1 (ru)
MX (2) MX347348B (ru)
MY (1) MY163214A (ru)
NO (1) NO2681192T3 (ru)
PE (1) PE20140917A1 (ru)
PL (1) PL2681192T3 (ru)
PT (1) PT2681192T (ru)
SG (1) SG192793A1 (ru)
SI (1) SI2681192T1 (ru)
TN (1) TN2013000354A1 (ru)
TW (2) TWI607994B (ru)
UA (1) UA112539C2 (ru)
WO (1) WO2012117071A1 (ru)
ZA (1) ZA201306174B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
KR20170083535A (ko) * 2014-11-14 2017-07-18 젬파이어 세러퓨틱스 인코포레이티드 α,ω-다이카복실산-말단 다이알케인 에터를 제조하기 위한 방법 및 중간체
JP7014737B2 (ja) 2017-01-20 2022-02-01 株式会社ペーターズ スケートボード用ハンドル及びハンドル付きスケートボード
CN112961090A (zh) * 2019-12-13 2021-06-15 武汉九州钰民医药科技有限公司 合成Alpelisib的关键中间体及其制备方法
CN110964005A (zh) * 2019-12-16 2020-04-07 武汉九州钰民医药科技有限公司 一种Alpelisib的制备工艺
CN111057051A (zh) * 2019-12-16 2020-04-24 武汉九州钰民医药科技有限公司 PI3K抑制剂Alpelisib的新合成方法
KR20220125753A (ko) 2021-03-05 2022-09-14 배성륭 기능성 풍력 발전시스템

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534056A (en) * 1967-03-02 1970-10-13 Pennwalt Corp Fluoro-alkyl pyridines and their preparation
UA60365C2 (ru) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Производные изотиазола, способ их получения, фармацевтическая композиция и способ лечения гиперпролиферативного заболевания у млекопитающего
DE60023926T2 (de) 1999-09-10 2006-07-20 Merck & Co., Inc. Tyrosin kinase inhibitoren
AR044519A1 (es) * 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
TWI444370B (zh) * 2006-01-25 2014-07-11 Synta Pharmaceuticals Corp 用於發炎及免疫相關用途之噻唑及噻二唑化合物
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
EA201000947A1 (ru) 2007-12-20 2011-02-28 Новартис Аг Производные тиазола, применимые в качестве ингибиторов киназы pi3
ATE517527T1 (de) * 2007-12-21 2011-08-15 Ericsson Telefon Ab L M Verfahren, vorrichtung und computerprogramm zum handover von einem ersten zugangspunkt an einen zweiten zugangspunkt
UA104147C2 (ru) * 2008-09-10 2014-01-10 Новартис Аг Производная пирролидиндикарбоновой кислоты и ее применение в лечении пролиферативных заболеваний
UA112539C2 (uk) * 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини

Also Published As

Publication number Publication date
PE20140917A1 (es) 2014-08-14
EA201792068A3 (ru) 2018-05-31
EA201792068A2 (ru) 2018-01-31
GT201300211A (es) 2014-12-30
CN106083840B (zh) 2020-01-03
TW201247660A (en) 2012-12-01
AR088714A1 (es) 2014-07-02
US9650373B2 (en) 2017-05-16
TW201722916A (zh) 2017-07-01
IL228023A0 (en) 2013-09-30
DK2681192T3 (en) 2018-04-16
AR123584A2 (es) 2022-12-21
EA032802B1 (ru) 2019-07-31
ECSP13012914A (es) 2013-11-29
CA2828509A1 (en) 2012-09-07
PL2681192T3 (pl) 2018-06-29
PT2681192T (pt) 2018-04-02
EA025381B1 (ru) 2016-12-30
CN103402982A (zh) 2013-11-20
HUE036319T2 (hu) 2018-06-28
JP6022485B2 (ja) 2016-11-09
EA201892052A1 (ru) 2019-02-28
KR101851421B1 (ko) 2018-04-23
CO6751286A2 (es) 2013-09-16
TN2013000354A1 (en) 2015-01-20
AU2012222346B2 (en) 2015-05-07
MY163214A (en) 2017-08-30
UA112539C2 (uk) 2016-09-26
SG192793A1 (en) 2013-09-30
CN103402982B (zh) 2016-07-13
SI2681192T1 (en) 2018-04-30
US9776966B2 (en) 2017-10-03
CN106083840A (zh) 2016-11-09
CA2828509C (en) 2018-11-20
US20170240509A1 (en) 2017-08-24
US20170355677A1 (en) 2017-12-14
EP2681192A1 (en) 2014-01-08
CL2013002521A1 (es) 2014-02-14
EA201691331A1 (ru) 2017-01-30
MX2013010132A (es) 2013-10-30
US10059670B2 (en) 2018-08-28
BR112013021882A2 (pt) 2016-07-19
JP2014511387A (ja) 2014-05-15
MX351740B (es) 2017-10-26
AU2012222346A1 (en) 2013-08-29
EP2681192B1 (en) 2017-12-27
NZ614173A (en) 2015-04-24
ZA201306174B (en) 2014-05-28
ES2663717T3 (es) 2018-04-16
US20130331579A1 (en) 2013-12-12
KR20140009432A (ko) 2014-01-22
WO2012117071A1 (en) 2012-09-07
TWI607994B (zh) 2017-12-11
NO2681192T3 (ru) 2018-05-26
MX347348B (es) 2017-04-17
MA34982B1 (fr) 2014-03-01
TWI597279B (zh) 2017-09-01
IL228023A (en) 2017-04-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KZ