EA201591292A1 - Тапентадола малеат и его кристаллические формы - Google Patents

Тапентадола малеат и его кристаллические формы

Info

Publication number
EA201591292A1
EA201591292A1 EA201591292A EA201591292A EA201591292A1 EA 201591292 A1 EA201591292 A1 EA 201591292A1 EA 201591292 A EA201591292 A EA 201591292A EA 201591292 A EA201591292 A EA 201591292A EA 201591292 A1 EA201591292 A1 EA 201591292A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tapentadola
maleat
crystalline forms
preparation
tapentadol
Prior art date
Application number
EA201591292A
Other languages
English (en)
Other versions
EA030553B1 (ru
Inventor
Ален Кляйиц
Ана Бергант Симончич
Аница Пецавар
Рок Зупет
Елена Смирнова
Original Assignee
ФАРМА ДжРС, Д.О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ФАРМА ДжРС, Д.О.О. filed Critical ФАРМА ДжРС, Д.О.О.
Publication of EA201591292A1 publication Critical patent/EA201591292A1/ru
Publication of EA030553B1 publication Critical patent/EA030553B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к новой и стабильной соли тапентадола, тапентадола малеату, ее полиморфным формам, а также к способам их получения, фармацевтическим композициям и их получению.
EA201591292A 2013-01-10 2014-01-10 Тапентадола малеат и его кристаллические формы EA030553B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI201300008 2013-01-10
SI201300032 2013-02-12
PCT/EP2014/050411 WO2014108514A1 (en) 2013-01-10 2014-01-10 Tapentadol maleate and crystalline forms thereof

Publications (2)

Publication Number Publication Date
EA201591292A1 true EA201591292A1 (ru) 2015-11-30
EA030553B1 EA030553B1 (ru) 2018-08-31

Family

ID=49955374

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591292A EA030553B1 (ru) 2013-01-10 2014-01-10 Тапентадола малеат и его кристаллические формы

Country Status (4)

Country Link
EP (1) EP2943454B1 (ru)
EA (1) EA030553B1 (ru)
SI (1) SI2943454T1 (ru)
WO (1) WO2014108514A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3377049B1 (en) 2015-11-17 2021-01-06 MSN Laboratories Private Limited Crystalline forms of tapentadol salts and process for preparation thereof
EP4121013A1 (en) 2020-03-16 2023-01-25 Grünenthal GmbH Scored tablet

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8288592B2 (en) * 2009-09-22 2012-10-16 Actavis Group Ptc Ehf Solid state forms of tapentadol salts

Also Published As

Publication number Publication date
WO2014108514A1 (en) 2014-07-17
SI2943454T1 (sl) 2022-01-31
EP2943454A1 (en) 2015-11-18
EA030553B1 (ru) 2018-08-31
EP2943454B1 (en) 2021-08-18

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title