IL108206A0 - Oligomers having improved stability at acid ph - Google Patents
Oligomers having improved stability at acid phInfo
- Publication number
- IL108206A0 IL108206A0 IL10820693A IL10820693A IL108206A0 IL 108206 A0 IL108206 A0 IL 108206A0 IL 10820693 A IL10820693 A IL 10820693A IL 10820693 A IL10820693 A IL 10820693A IL 108206 A0 IL108206 A0 IL 108206A0
- Authority
- IL
- Israel
- Prior art keywords
- oligomers
- acid
- improved stability
- stability
- improved
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110993A | 1993-01-06 | 1993-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL108206A0 true IL108206A0 (en) | 1994-04-12 |
Family
ID=21694414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10820693A IL108206A0 (en) | 1993-01-06 | 1993-12-28 | Oligomers having improved stability at acid ph |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0690716A4 (en) |
JP (1) | JPH08505396A (en) |
KR (1) | KR960700062A (en) |
CN (1) | CN1118140A (en) |
AU (1) | AU692143B2 (en) |
CA (1) | CA2152672A1 (en) |
IL (1) | IL108206A0 (en) |
NZ (1) | NZ261253A (en) |
WO (1) | WO1994015619A1 (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147204A (en) * | 1990-06-11 | 2000-11-14 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
US6465188B1 (en) | 1990-06-11 | 2002-10-15 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
US6011020A (en) * | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
US6015886A (en) * | 1993-05-24 | 2000-01-18 | Chemgenes Corporation | Oligonucleotide phosphate esters |
US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
US6608035B1 (en) | 1994-10-25 | 2003-08-19 | Hybridon, Inc. | Method of down-regulating gene expression |
US5591721A (en) * | 1994-10-25 | 1997-01-07 | Hybridon, Inc. | Method of down-regulating gene expression |
US6645943B1 (en) | 1994-10-25 | 2003-11-11 | Hybridon, Inc. | Method of down-regulating gene expression |
US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
US5859228A (en) * | 1995-05-04 | 1999-01-12 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US8071737B2 (en) | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
US6229002B1 (en) | 1995-06-07 | 2001-05-08 | Nexstar Pharmaceuticlas, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
US6051698A (en) * | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6426335B1 (en) | 1997-10-17 | 2002-07-30 | Gilead Sciences, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
JP4787409B2 (en) * | 1998-12-30 | 2011-10-05 | レイクウッド−アメディックス,インコーポレーテッド | Therapeutic phosphodiesterase inhibitors |
US6211349B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc., Inc. | Protonated/acidified nucleic acids and methods of use |
US7868162B2 (en) | 1998-12-30 | 2011-01-11 | Lakewood-Amedex, Inc. | Antimicrobial and antiviral compounds and methods for their use |
US6627215B1 (en) | 1998-12-30 | 2003-09-30 | Oligos Etc. Inc. | Devices for improved wound management |
US6211162B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc. Inc. | Pulmonary delivery of protonated/acidified nucleic acids |
US6087112A (en) * | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
AU5269600A (en) * | 1999-05-13 | 2000-12-05 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
US6844151B1 (en) * | 1999-09-29 | 2005-01-18 | Oligos Etc. Inc. | Methods for production of arrays with modified oligonucleotide and polynucleotide compositions |
US20030207834A1 (en) | 2001-07-10 | 2003-11-06 | Dale Roderic M.K. | Oligonucleotide-containing pharmacological compositions and their use |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
AU2007283022B2 (en) | 2006-08-08 | 2011-07-28 | Rheinische Friedrich-Wilhelms-Universitat Bonn | Structure and use of 5' phosphate oligonucleotides |
EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
CN101824063B (en) * | 2010-04-16 | 2013-07-24 | 北京欧凯纳斯科技有限公司 | Alkyl modified nucleic acid and modification method and application thereof |
EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
KR20150139582A (en) | 2013-04-04 | 2015-12-11 | 조지아 스테이트 유니버시티 리서치 파운데이션, 인크. | Rna microchip detection using nanoparticle-assisted signal amplification |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511713A (en) * | 1980-11-12 | 1985-04-16 | The Johns Hopkins University | Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells |
IT1188212B (en) * | 1985-12-20 | 1988-01-07 | Paolo Colombo | SYSTEM FOR THE RELEASE SPEED OF ACTIVE SUBSTANCES |
DE3788914T2 (en) * | 1986-09-08 | 1994-08-25 | Ajinomoto Kk | Compounds for cleaving RNA at a specific position, oligomers used in the preparation of these compounds and starting materials for the synthesis of these oligomers. |
-
1993
- 1993-12-28 IL IL10820693A patent/IL108206A0/en unknown
-
1994
- 1994-01-05 CA CA002152672A patent/CA2152672A1/en not_active Abandoned
- 1994-01-05 NZ NZ261253A patent/NZ261253A/en unknown
- 1994-01-05 JP JP6516188A patent/JPH08505396A/en active Pending
- 1994-01-05 WO PCT/US1994/000157 patent/WO1994015619A1/en not_active Application Discontinuation
- 1994-01-05 KR KR1019950702783A patent/KR960700062A/en not_active Application Discontinuation
- 1994-01-05 AU AU59924/94A patent/AU692143B2/en not_active Ceased
- 1994-01-05 EP EP94906041A patent/EP0690716A4/en not_active Withdrawn
- 1994-01-05 CN CN94191223A patent/CN1118140A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1994015619A1 (en) | 1994-07-21 |
EP0690716A1 (en) | 1996-01-10 |
CA2152672A1 (en) | 1994-07-21 |
EP0690716A4 (en) | 1997-05-02 |
JPH08505396A (en) | 1996-06-11 |
NZ261253A (en) | 1997-07-27 |
AU5992494A (en) | 1994-08-15 |
KR960700062A (en) | 1996-01-19 |
CN1118140A (en) | 1996-03-06 |
AU692143B2 (en) | 1998-06-04 |
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