EP0690716A4 - OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH - Google Patents

OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Info

Publication number
EP0690716A4
EP0690716A4 EP94906041A EP94906041A EP0690716A4 EP 0690716 A4 EP0690716 A4 EP 0690716A4 EP 94906041 A EP94906041 A EP 94906041A EP 94906041 A EP94906041 A EP 94906041A EP 0690716 A4 EP0690716 A4 EP 0690716A4
Authority
EP
European Patent Office
Prior art keywords
acid
improve stability
oligonucleotides modified
oligonucleotides
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94906041A
Other languages
German (de)
French (fr)
Other versions
EP0690716A1 (en
Inventor
Paul Scott Miller
O Paul On-Pong Ts
Lionel Norton Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Genta Inc
Original Assignee
Johns Hopkins University
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, Genta Inc filed Critical Johns Hopkins University
Publication of EP0690716A1 publication Critical patent/EP0690716A1/en
Publication of EP0690716A4 publication Critical patent/EP0690716A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
EP94906041A 1993-01-06 1994-01-05 OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH Withdrawn EP0690716A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US110993A 1993-01-06 1993-01-06
US1109 1993-01-06
PCT/US1994/000157 WO1994015619A1 (en) 1993-01-06 1994-01-05 OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Publications (2)

Publication Number Publication Date
EP0690716A1 EP0690716A1 (en) 1996-01-10
EP0690716A4 true EP0690716A4 (en) 1997-05-02

Family

ID=21694414

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94906041A Withdrawn EP0690716A4 (en) 1993-01-06 1994-01-05 OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Country Status (9)

Country Link
EP (1) EP0690716A4 (en)
JP (1) JPH08505396A (en)
KR (1) KR960700062A (en)
CN (1) CN1118140A (en)
AU (1) AU692143B2 (en)
CA (1) CA2152672A1 (en)
IL (1) IL108206A0 (en)
NZ (1) NZ261253A (en)
WO (1) WO1994015619A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6147204A (en) * 1990-06-11 2000-11-14 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6465188B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US5591721A (en) * 1994-10-25 1997-01-07 Hybridon, Inc. Method of down-regulating gene expression
US6645943B1 (en) 1994-10-25 2003-11-11 Hybridon, Inc. Method of down-regulating gene expression
US6608035B1 (en) 1994-10-25 2003-08-19 Hybridon, Inc. Method of down-regulating gene expression
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
US5859228A (en) * 1995-05-04 1999-01-12 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US6229002B1 (en) 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6426335B1 (en) 1997-10-17 2002-07-30 Gilead Sciences, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6051698A (en) * 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US7868162B2 (en) 1998-12-30 2011-01-11 Lakewood-Amedex, Inc. Antimicrobial and antiviral compounds and methods for their use
US6211162B1 (en) * 1998-12-30 2001-04-03 Oligos Etc. Inc. Pulmonary delivery of protonated/acidified nucleic acids
US6211349B1 (en) * 1998-12-30 2001-04-03 Oligos Etc., Inc. Protonated/acidified nucleic acids and methods of use
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6627215B1 (en) 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
JP4787409B2 (en) * 1998-12-30 2011-10-05 レイクウッド−アメディックス，インコーポレーテッド Therapeutic phosphodiesterase inhibitors
WO2000070093A1 (en) * 1999-05-13 2000-11-23 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6844151B1 (en) * 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
EP2351765A3 (en) 2001-07-10 2012-02-22 Lakewood-Amedex, Inc Oligonucleotide-containing pharmacological compositions and their use
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
SI2056845T1 (en) 2006-08-08 2018-02-28 Rheinische Friedrich-Wilhelms-Universitaet Bonn Structure and use of 5' phosphate oligonucleotides
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
CN101824063B (en) * 2010-04-16 2013-07-24 北京欧凯纳斯科技有限公司 Alkyl modified nucleic acid and modification method and application thereof
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
JP2016515827A (en) 2013-04-04 2016-06-02 ジョージア ステイト ユニバーシティ リサーチ ファンデーション， インコーポレイテッド RNA microchip detection using nanoparticle-assisted signal amplification

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
EP0260032A2 (en) * 1986-09-08 1988-03-16 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1188212B (en) * 1985-12-20 1988-01-07 Paolo Colombo SYSTEM FOR THE RELEASE SPEED OF ACTIVE SUBSTANCES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
EP0260032A2 (en) * 1986-09-08 1988-03-16 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H.INOUE ET AL.: "Synthesis and Hybridization Studies on two Complementary Nona(2'-O-methyl)ribonucleotides.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 15, 1987, OXFORD GB, pages 6131 - 6148, XP000570336 *
I.HIRAO ET AL.: "Synthesis and Properties of an Initiation Codon Analog Consisting of 2'-O-Methyl Nucleotides.", NUCLEOSIDES AND NUCLEOTIDES, vol. 9, no. 8, 1990, pages 1113 - 1122, XP000609767 *
R.KIERZEK ET AL.: "Some Steric Aspects of Synthesis of Oligoribonucleotides by Phosphoramidite Approach on Solid Support.", BULLETIN OF THE POLISH ACADEMY OF SCIENCES, vol. 35, no. 11-12, 1987, pages 507 - 516, XP000609848 *
S.SHIBAHARA ET AL.: "Sire-Directed Cleavage of RNA.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 11, 1987, OXFORD GB, pages 4403 - 4415, XP000609038 *
See also references of WO9415619A1 *

Also Published As

Publication number Publication date
NZ261253A (en) 1997-07-27
JPH08505396A (en) 1996-06-11
AU5992494A (en) 1994-08-15
CA2152672A1 (en) 1994-07-21
AU692143B2 (en) 1998-06-04
WO1994015619A1 (en) 1994-07-21
IL108206A0 (en) 1994-04-12
CN1118140A (en) 1996-03-06
KR960700062A (en) 1996-01-19
EP0690716A1 (en) 1996-01-10

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