EP0690716A4 - Modifizierte oligonukleotide zur verbesserung der stabilität im saurem ph-bereich - Google Patents

Modifizierte oligonukleotide zur verbesserung der stabilität im saurem ph-bereich

Info

Publication number
EP0690716A4
EP0690716A4 EP94906041A EP94906041A EP0690716A4 EP 0690716 A4 EP0690716 A4 EP 0690716A4 EP 94906041 A EP94906041 A EP 94906041A EP 94906041 A EP94906041 A EP 94906041A EP 0690716 A4 EP0690716 A4 EP 0690716A4
Authority
EP
European Patent Office
Prior art keywords
acid
improve stability
oligonucleotides modified
oligonucleotides
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94906041A
Other languages
English (en)
French (fr)
Other versions
EP0690716A1 (de
Inventor
Paul Scott Miller
O Paul On-Pong Ts
Lionel Norton Simon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
Genta Inc
Original Assignee
Johns Hopkins University
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, Genta Inc filed Critical Johns Hopkins University
Publication of EP0690716A1 publication Critical patent/EP0690716A1/de
Publication of EP0690716A4 publication Critical patent/EP0690716A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
EP94906041A 1993-01-06 1994-01-05 Modifizierte oligonukleotide zur verbesserung der stabilität im saurem ph-bereich Withdrawn EP0690716A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US110993A 1993-01-06 1993-01-06
US1109 1993-01-06
PCT/US1994/000157 WO1994015619A1 (en) 1993-01-06 1994-01-05 OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH

Publications (2)

Publication Number Publication Date
EP0690716A1 EP0690716A1 (de) 1996-01-10
EP0690716A4 true EP0690716A4 (de) 1997-05-02

Family

ID=21694414

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94906041A Withdrawn EP0690716A4 (de) 1993-01-06 1994-01-05 Modifizierte oligonukleotide zur verbesserung der stabilität im saurem ph-bereich

Country Status (9)

Country Link
EP (1) EP0690716A4 (de)
JP (1) JPH08505396A (de)
KR (1) KR960700062A (de)
CN (1) CN1118140A (de)
AU (1) AU692143B2 (de)
CA (1) CA2152672A1 (de)
IL (1) IL108206A0 (de)
NZ (1) NZ261253A (de)
WO (1) WO1994015619A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011020A (en) * 1990-06-11 2000-01-04 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6147204A (en) * 1990-06-11 2000-11-14 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand complexes
US6465188B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US6645943B1 (en) 1994-10-25 2003-11-11 Hybridon, Inc. Method of down-regulating gene expression
US5591721A (en) * 1994-10-25 1997-01-07 Hybridon, Inc. Method of down-regulating gene expression
US6608035B1 (en) 1994-10-25 2003-08-19 Hybridon, Inc. Method of down-regulating gene expression
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US5859228A (en) * 1995-05-04 1999-01-12 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6229002B1 (en) 1995-06-07 2001-05-08 Nexstar Pharmaceuticlas, Inc. Platelet derived growth factor (PDGF) nucleic acid ligand complexes
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6426335B1 (en) 1997-10-17 2002-07-30 Gilead Sciences, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6051698A (en) * 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6087112A (en) * 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6211162B1 (en) * 1998-12-30 2001-04-03 Oligos Etc. Inc. Pulmonary delivery of protonated/acidified nucleic acids
US6211349B1 (en) * 1998-12-30 2001-04-03 Oligos Etc., Inc. Protonated/acidified nucleic acids and methods of use
EP1141278B1 (de) * 1998-12-30 2008-02-27 Oligos Etc. Inc. Therapeutische pde4d phosphodiesterase inhibitoren
US7868162B2 (en) 1998-12-30 2011-01-11 Lakewood-Amedex, Inc. Antimicrobial and antiviral compounds and methods for their use
US6627215B1 (en) 1998-12-30 2003-09-30 Oligos Etc. Inc. Devices for improved wound management
AU5269600A (en) * 1999-05-13 2000-12-05 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6844151B1 (en) * 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
IL159722A0 (en) 2001-07-10 2004-06-20 Oligos Etc Inc Pharmaceutical compositions containing oligonucleotides
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
EP4082551A1 (de) 2006-08-08 2022-11-02 Rheinische Friedrich-Wilhelms-Universität Bonn Struktur und verwendung von 5'-phosphat-oligonukleotiden
EP2297323A1 (de) 2008-05-21 2011-03-23 Hartmann, Gunther 5 -triphosphat-oligonukleotid mit stumpfem ende und verwendugen davon
CN101824063B (zh) * 2010-04-16 2013-07-24 北京欧凯纳斯科技有限公司 一种用烷基修饰的核酸及其修饰方法和应用
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
US20160068894A1 (en) 2013-04-04 2016-03-10 Georgia State University Research Foundation, Inc. RNA Microchip Detection Using Nanoparticle-Assisted Signal Amplification

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
EP0260032A2 (de) * 1986-09-08 1988-03-16 Ajinomoto Co., Inc. Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1188212B (it) * 1985-12-20 1988-01-07 Paolo Colombo Sistema per il rilascio a velocita' controllata di sostanze attive

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
EP0260032A2 (de) * 1986-09-08 1988-03-16 Ajinomoto Co., Inc. Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H.INOUE ET AL.: "Synthesis and Hybridization Studies on two Complementary Nona(2'-O-methyl)ribonucleotides.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 15, 1987, OXFORD GB, pages 6131 - 6148, XP000570336 *
I.HIRAO ET AL.: "Synthesis and Properties of an Initiation Codon Analog Consisting of 2'-O-Methyl Nucleotides.", NUCLEOSIDES AND NUCLEOTIDES, vol. 9, no. 8, 1990, pages 1113 - 1122, XP000609767 *
R.KIERZEK ET AL.: "Some Steric Aspects of Synthesis of Oligoribonucleotides by Phosphoramidite Approach on Solid Support.", BULLETIN OF THE POLISH ACADEMY OF SCIENCES, vol. 35, no. 11-12, 1987, pages 507 - 516, XP000609848 *
S.SHIBAHARA ET AL.: "Sire-Directed Cleavage of RNA.", NUCLEIC ACIDS RESEARCH, vol. 15, no. 11, 1987, OXFORD GB, pages 4403 - 4415, XP000609038 *
See also references of WO9415619A1 *

Also Published As

Publication number Publication date
NZ261253A (en) 1997-07-27
EP0690716A1 (de) 1996-01-10
CA2152672A1 (en) 1994-07-21
AU5992494A (en) 1994-08-15
CN1118140A (zh) 1996-03-06
AU692143B2 (en) 1998-06-04
WO1994015619A1 (en) 1994-07-21
JPH08505396A (ja) 1996-06-11
KR960700062A (ko) 1996-01-19
IL108206A0 (en) 1994-04-12

Similar Documents

Publication Publication Date Title
EP0690716A4 (de) Modifizierte oligonukleotide zur verbesserung der stabilität im saurem ph-bereich
GB9504065D0 (en) Poly-pyrrolecarboxamidonaphthalenic acid derivatives
ZA941575B (en) Phosphonic acid derivatives
ZA94332B (en) Quinolone- and naphtyridonecarboxylic acid derivatives
GB2316411B (en) Nucleic Acid Sequencing Gels
GB9522615D0 (en) 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
ZA969179B (en) 4-Phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity
SG54218A1 (en) 2-keto-3-methyl-4-hydroxy-valeric acid
NZ286622A (en) Fluorophenylalkenylcarboxylic acid guanidides
ZA93190B (en) Benzofuranyl- and thiophenylmethylthio-alkanecarboxylic acid derivatives
ZA95225B (en) alpha-pyrimidinyl acrylic acid derivatives
EP0774965A4 (de) Phenoxyphenylessigsäurederivate
HU9403116D0 (en) Epoxy-succinic acid derivatives
GB2285978B (en) Novel kojic acid derivatives
ZA941668B (en) Acyloxyhexanoic acid derivatives
HU9401898D0 (en) Acid microemulsion composition
HUT71606A (en) Amino-ascorbic acid derivatives, halogen-ascorbic acid derivatives and process to prepare them
AU7516094A (en) Antibodies specific to quinolinic acid
ZA931367B (en) Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives
IL110170A0 (en) 2-Oximino-2-thienyl-acetic acid derivatives
ZA941923B (en) Phenoxyphenylacetic acid derivatives
AU6243094A (en) Stable aqueous acid compositions thickened with polyacrylamide
ZA93125B (en) Quinolone- and naphthyridone-carboxylic acid derivatives
HU9502630D0 (en) Process to manufacture alkylbenzenesulphonic acid
ZA968751B (en) Fluoromethoxyacrylic acid derivatives

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19950804

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19970318

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 19981211

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19990422