IL108206A0 - Oligomers having improved stability at acid ph - Google Patents
Oligomers having improved stability at acid phInfo
- Publication number
- IL108206A0 IL108206A0 IL10820693A IL10820693A IL108206A0 IL 108206 A0 IL108206 A0 IL 108206A0 IL 10820693 A IL10820693 A IL 10820693A IL 10820693 A IL10820693 A IL 10820693A IL 108206 A0 IL108206 A0 IL 108206A0
- Authority
- IL
- Israel
- Prior art keywords
- oligomers
- acid
- improved stability
- stability
- improved
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110993A | 1993-01-06 | 1993-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL108206A0 true IL108206A0 (en) | 1994-04-12 |
Family
ID=21694414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10820693A IL108206A0 (en) | 1993-01-06 | 1993-12-28 | Oligomers having improved stability at acid ph |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0690716A4 (xx) |
JP (1) | JPH08505396A (xx) |
KR (1) | KR960700062A (xx) |
CN (1) | CN1118140A (xx) |
AU (1) | AU692143B2 (xx) |
CA (1) | CA2152672A1 (xx) |
IL (1) | IL108206A0 (xx) |
NZ (1) | NZ261253A (xx) |
WO (1) | WO1994015619A1 (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465188B1 (en) | 1990-06-11 | 2002-10-15 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
US6011020A (en) * | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
US6147204A (en) * | 1990-06-11 | 2000-11-14 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
US6015886A (en) * | 1993-05-24 | 2000-01-18 | Chemgenes Corporation | Oligonucleotide phosphate esters |
US5869248A (en) * | 1994-03-07 | 1999-02-09 | Yale University | Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences |
US6645943B1 (en) | 1994-10-25 | 2003-11-11 | Hybridon, Inc. | Method of down-regulating gene expression |
US5591721A (en) * | 1994-10-25 | 1997-01-07 | Hybridon, Inc. | Method of down-regulating gene expression |
US6608035B1 (en) | 1994-10-25 | 2003-08-19 | Hybridon, Inc. | Method of down-regulating gene expression |
US6057153A (en) * | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
US5859228A (en) * | 1995-05-04 | 1999-01-12 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US8071737B2 (en) | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
US6229002B1 (en) | 1995-06-07 | 2001-05-08 | Nexstar Pharmaceuticlas, Inc. | Platelet derived growth factor (PDGF) nucleic acid ligand complexes |
US6610478B1 (en) | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
US6426335B1 (en) | 1997-10-17 | 2002-07-30 | Gilead Sciences, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6051698A (en) * | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
US6211349B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc., Inc. | Protonated/acidified nucleic acids and methods of use |
US6087112A (en) | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
AU781577B2 (en) * | 1998-12-30 | 2005-06-02 | Lakewood-Amedex, Inc. | Therapeutic phosphodiesterase inhibitors |
US6627215B1 (en) | 1998-12-30 | 2003-09-30 | Oligos Etc. Inc. | Devices for improved wound management |
US7868162B2 (en) | 1998-12-30 | 2011-01-11 | Lakewood-Amedex, Inc. | Antimicrobial and antiviral compounds and methods for their use |
US6211162B1 (en) * | 1998-12-30 | 2001-04-03 | Oligos Etc. Inc. | Pulmonary delivery of protonated/acidified nucleic acids |
AU5269600A (en) * | 1999-05-13 | 2000-12-05 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
US6844151B1 (en) * | 1999-09-29 | 2005-01-18 | Oligos Etc. Inc. | Methods for production of arrays with modified oligonucleotide and polynucleotide compositions |
EP1414841B1 (en) | 2001-07-10 | 2012-11-14 | Lakewood-Amedex, Inc | Oligonucleotide-containing pharmacological compositions and their use |
US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
EP2056845B1 (en) | 2006-08-08 | 2017-10-11 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
JP5689413B2 (ja) | 2008-05-21 | 2015-03-25 | ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン | 平滑末端を有する5’三リン酸オリゴヌクレオチドおよびその使用 |
CN101824063B (zh) * | 2010-04-16 | 2013-07-24 | 北京欧凯纳斯科技有限公司 | 一种用烷基修饰的核酸及其修饰方法和应用 |
EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
CN105283561A (zh) | 2013-04-04 | 2016-01-27 | 佐治亚州立大学研究基金会公司 | 使用纳米粒子辅助信号放大的rna微芯片检测 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4511713A (en) * | 1980-11-12 | 1985-04-16 | The Johns Hopkins University | Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells |
IT1188212B (it) * | 1985-12-20 | 1988-01-07 | Paolo Colombo | Sistema per il rilascio a velocita' controllata di sostanze attive |
DE3788914T2 (de) * | 1986-09-08 | 1994-08-25 | Ajinomoto Kk | Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere. |
-
1993
- 1993-12-28 IL IL10820693A patent/IL108206A0/xx unknown
-
1994
- 1994-01-05 EP EP94906041A patent/EP0690716A4/en not_active Withdrawn
- 1994-01-05 CA CA002152672A patent/CA2152672A1/en not_active Abandoned
- 1994-01-05 JP JP6516188A patent/JPH08505396A/ja active Pending
- 1994-01-05 AU AU59924/94A patent/AU692143B2/en not_active Ceased
- 1994-01-05 KR KR1019950702783A patent/KR960700062A/ko not_active Application Discontinuation
- 1994-01-05 WO PCT/US1994/000157 patent/WO1994015619A1/en not_active Application Discontinuation
- 1994-01-05 CN CN94191223A patent/CN1118140A/zh active Pending
- 1994-01-05 NZ NZ261253A patent/NZ261253A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1118140A (zh) | 1996-03-06 |
CA2152672A1 (en) | 1994-07-21 |
NZ261253A (en) | 1997-07-27 |
KR960700062A (ko) | 1996-01-19 |
WO1994015619A1 (en) | 1994-07-21 |
AU692143B2 (en) | 1998-06-04 |
EP0690716A4 (en) | 1997-05-02 |
AU5992494A (en) | 1994-08-15 |
EP0690716A1 (en) | 1996-01-10 |
JPH08505396A (ja) | 1996-06-11 |
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