EP0774965A4 - Phenoxyphenylacetic acid derivatives - Google Patents

Phenoxyphenylacetic acid derivatives

Info

Publication number
EP0774965A4
EP0774965A4 EP95929396A EP95929396A EP0774965A4 EP 0774965 A4 EP0774965 A4 EP 0774965A4 EP 95929396 A EP95929396 A EP 95929396A EP 95929396 A EP95929396 A EP 95929396A EP 0774965 A4 EP0774965 A4 EP 0774965A4
Authority
EP
European Patent Office
Prior art keywords
acid derivatives
phenoxyphenylacetic acid
phenoxyphenylacetic
derivatives
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95929396A
Other languages
German (de)
French (fr)
Other versions
EP0774965A1 (en
Inventor
Scott W Bagley
Theodore P Broten
Prasun K Chakravarty
Daljit S Dhanoa
Kenneth J Fitch
William J Greenlee
Nancy Jo Kevin
Gerard R Kieczykowski
Jay M Matthews
Douglas J Pettibone
Ralph A Rivero
James R Tata
Thomas F Walsh
David L Willams Jr
Richard B Toupence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/294,232 external-priority patent/US5565485A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0774965A1 publication Critical patent/EP0774965A1/en
Publication of EP0774965A4 publication Critical patent/EP0774965A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
EP95929396A 1994-08-08 1995-08-07 Phenoxyphenylacetic acid derivatives Withdrawn EP0774965A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US28737494A 1994-08-08 1994-08-08
US08/294,232 US5565485A (en) 1993-03-19 1994-08-22 Biphenyl compounds useful or endothelin antagonists
US294232 1994-08-22
US47317295A 1995-06-07 1995-06-07
US473172 1995-06-07
PCT/US1995/009967 WO1996004905A1 (en) 1994-08-08 1995-08-07 Phenoxyphenylacetic acid derivatives
US287374 1999-04-07

Publications (2)

Publication Number Publication Date
EP0774965A1 EP0774965A1 (en) 1997-05-28
EP0774965A4 true EP0774965A4 (en) 1997-10-29

Family

ID=27403702

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95929396A Withdrawn EP0774965A4 (en) 1994-08-08 1995-08-07 Phenoxyphenylacetic acid derivatives

Country Status (4)

Country Link
EP (1) EP0774965A4 (en)
JP (1) JPH10503779A (en)
CA (1) CA2195758A1 (en)
WO (1) WO1996004905A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688974A (en) * 1995-12-12 1997-11-18 Merck & Co., Inc. Process for the preparation of an endothelin antagonist
JP2000502998A (en) * 1995-12-12 2000-03-14 メルク エンド カンパニー インコーポレーテッド Method for producing endothelin antagonist
US6410554B1 (en) 1998-03-23 2002-06-25 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
AU3011299A (en) * 1998-03-23 1999-10-18 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
WO2003080545A2 (en) * 2002-03-20 2003-10-02 Metabolex, Inc. Substituted phenylacetic acids
EP2436675A1 (en) * 2009-05-29 2012-04-04 Kowa Company, Ltd. Novel -phenoxybenzeneacetic acid derivative and pharmaceutical preparation comprising same
EP2590951B1 (en) 2010-07-09 2015-01-07 Pfizer Limited Benzenesulfonamides useful as sodium channel inhibitors
US9096500B2 (en) 2010-07-12 2015-08-04 Pfizer Limited Acyl sulfonamide compounds
EP2593432B1 (en) 2010-07-12 2014-10-22 Pfizer Limited N-sulfonylbenzamide derivatives useful as voltage gated sodium channel inhibitors
CA2800971A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
EP2593427B1 (en) 2010-07-12 2014-12-24 Pfizer Limited Sulfonamide derivatives as nav1.7 inhibitors for the treatment of pain
CA2804351A1 (en) 2010-07-12 2012-01-19 Pfizer Limited Chemical compounds
ES2593533T3 (en) 2011-12-15 2016-12-09 Pfizer Limited Sulfonamide derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021590A1 (en) * 1993-03-19 1994-09-29 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
WO1996008487A1 (en) * 1994-09-14 1996-03-21 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334598A (en) * 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021590A1 (en) * 1993-03-19 1994-09-29 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
WO1996008487A1 (en) * 1994-09-14 1996-03-21 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9604905A1 *

Also Published As

Publication number Publication date
WO1996004905A1 (en) 1996-02-22
EP0774965A1 (en) 1997-05-28
CA2195758A1 (en) 1996-02-22
JPH10503779A (en) 1998-04-07

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Legal Events

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