DE68927417T2 - Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel - Google Patents

Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel

Info

Publication number
DE68927417T2
DE68927417T2 DE1989627417 DE68927417T DE68927417T2 DE 68927417 T2 DE68927417 T2 DE 68927417T2 DE 1989627417 DE1989627417 DE 1989627417 DE 68927417 T DE68927417 T DE 68927417T DE 68927417 T2 DE68927417 T2 DE 68927417T2
Authority
DE
Germany
Prior art keywords
antiviral agents
oligoribonucleotide derivatives
oligoribonucleotide
derivatives
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1989627417
Other languages
English (en)
Other versions
DE68927417D1 (de
Inventor
Susumu Central Resea Shibahara
Hirokazu Central Rese Morisawa
Hideki Nakajima
Naoki Yamamoto
Sachiko C O Central Rese Mukai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27564029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68927417(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP1064058A external-priority patent/JP2976436B2/ja
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE68927417D1 publication Critical patent/DE68927417D1/de
Publication of DE68927417T2 publication Critical patent/DE68927417T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1989627417 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel Expired - Lifetime DE68927417T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP10494388 1988-04-27
JP13896688 1988-06-06
JP16814288 1988-07-06
JP22788788 1988-09-12
JP23848188 1988-09-22
JP2437289 1989-02-02
JP1064058A JP2976436B2 (ja) 1988-04-27 1989-03-16 新規オリゴリボヌクレオチド誘導体及び抗ウイルス剤への使用

Publications (2)

Publication Number Publication Date
DE68927417D1 DE68927417D1 (de) 1996-12-12
DE68927417T2 true DE68927417T2 (de) 1997-03-20

Family

ID=27564029

Family Applications (5)

Application Number Title Priority Date Filing Date
DE1989629305 Expired - Lifetime DE68929305T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989629306 Expired - Lifetime DE68929306T2 (de) 1988-04-27 1989-04-13 H-Phosphonat Ribonucleotid-Derivate
DE1989629304 Expired - Lifetime DE68929304T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel
DE1989629361 Expired - Lifetime DE68929361T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989627417 Expired - Lifetime DE68927417T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DE1989629305 Expired - Lifetime DE68929305T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989629306 Expired - Lifetime DE68929306T2 (de) 1988-04-27 1989-04-13 H-Phosphonat Ribonucleotid-Derivate
DE1989629304 Expired - Lifetime DE68929304T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel
DE1989629361 Expired - Lifetime DE68929361T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel

Country Status (2)

Country Link
EP (1) EP0339842B1 (de)
DE (5) DE68929305T2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
EP0942000B1 (de) 1989-10-24 2004-06-23 Isis Pharmaceuticals, Inc. 2'-Modifizierte Oligonukleotide
US5623065A (en) * 1990-08-13 1997-04-22 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5955589A (en) * 1991-12-24 1999-09-21 Isis Pharmaceuticals Inc. Gapped 2' modified oligonucleotides
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US6034233A (en) * 1990-05-04 2000-03-07 Isis Pharmaceuticals Inc. 2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
JPH0813274B2 (ja) * 1990-08-13 1996-02-14 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド
EP0558749A1 (de) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense-nukleinsäurederivate
US7015315B1 (en) * 1991-12-24 2006-03-21 Isis Pharmaceuticals, Inc. Gapped oligonucleotides
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
US7119184B2 (en) 1991-08-12 2006-10-10 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US6307040B1 (en) * 1992-03-05 2001-10-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5525719A (en) * 1991-08-30 1996-06-11 Chemgenes Corporation N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5856455A (en) * 1991-12-24 1999-01-05 Isis Pharmaceuticals, Inc. Gapped 2'-modified oligonucleotides
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
ATE515510T1 (de) 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc Durch dna-abschnitte unterbrochene modifizierte oligonukleotide
US5652355A (en) * 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
TW244371B (de) * 1992-07-23 1995-04-01 Tri Clover Inc
US6346614B1 (en) 1992-07-23 2002-02-12 Hybridon, Inc. Hybrid oligonucleotide phosphorothioates
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
DE4427219A1 (de) * 1994-08-01 1996-02-08 Max Planck Gesellschaft Nukleinsäure zur Initiation der Aktivität von RNase H bzw. reverser Transkriptase
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
JPH10512894A (ja) 1995-03-06 1998-12-08 アイシス・ファーマシューティカルス・インコーポレーテッド ２’−ｏ−置換ピリミジンおよびそのオリゴマー化合物の合成の改良法
US6166197A (en) * 1995-03-06 2000-12-26 Isis Pharmaceuticals, Inc. Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
TR199801581T2 (xx) 1996-02-14 1998-10-21 Isis Pharmaceuticals, Inc. �ekerle de�i�tirilmi� bo�luklu oligon�kleotid'ler.
US5856099A (en) * 1996-05-21 1999-01-05 Isis Pharmaceuticals, Inc. Antisense compositions and methods for modulating type I interleukin-1 receptor expression
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6172217B1 (en) 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US6127533A (en) 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US6576752B1 (en) 1997-02-14 2003-06-10 Isis Pharmaceuticals, Inc. Aminooxy functionalized oligomers
US6172209B1 (en) 1997-02-14 2001-01-09 Isis Pharmaceuticals Inc. Aminooxy-modified oligonucleotides and methods for making same
US20030036516A1 (en) * 1997-09-10 2003-02-20 Sudhir Agrawal Method for using oligonucleotides having modified cpg dinucleotides
EP1537208A1 (de) 2002-09-13 2005-06-08 Replicor, Inc. Nicht-sequenzkomplementäre antivirale oligonukleotide
SI2056845T1 (en) 2006-08-08 2018-02-28 Rheinische Friedrich-Wilhelms-Universitaet Bonn STRUCTURE AND USE 5 'PHOSPHATE OF OLIGONUCLEOTES
US7820810B2 (en) 2007-03-19 2010-10-26 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted purine nulceosides
US9738680B2 (en) 2008-05-21 2017-08-22 Rheinische Friedrich-Wilhelms-Universität Bonn 5′ triphosphate oligonucleotide with blunt end and uses thereof
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
JP2016515827A (ja) 2013-04-04 2016-06-02 ジョージア ステイト ユニバーシティ リサーチ ファンデーション， インコーポレイテッド ナノ粒子支援シグナル増幅を使用するｒｎａマイクロチップ検出

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
JPS61291595A (ja) * 1985-06-19 1986-12-22 Ajinomoto Co Inc ２′−ｏ−メチル化ｒｎａの製造法

Also Published As

Publication number Publication date
DE68929306D1 (de) 2001-07-19
EP0339842B1 (de) 1996-11-06
DE68929306T2 (de) 2002-05-02
DE68929304D1 (de) 2001-07-19
DE68929361T2 (de) 2002-06-20
DE68927417D1 (de) 1996-12-12
EP0339842A2 (de) 1989-11-02
EP0339842A3 (de) 1994-03-09
DE68929361D1 (de) 2002-01-31
DE68929305D1 (de) 2001-07-19
DE68929305T2 (de) 2002-05-02
DE68929304T2 (de) 2002-04-25

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings