MX9203459A - Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina. - Google Patents

Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.

Info

Publication number
MX9203459A
MX9203459A MX9203459A MX9203459A MX9203459A MX 9203459 A MX9203459 A MX 9203459A MX 9203459 A MX9203459 A MX 9203459A MX 9203459 A MX9203459 A MX 9203459A MX 9203459 A MX9203459 A MX 9203459A
Authority
MX
Mexico
Prior art keywords
uridina
halometilideno
guanosina
etinilcitidina
etenilideno
Prior art date
Application number
MX9203459A
Other languages
English (en)
Inventor
James R Mccarthy
Michael L Edwards
Donald P Matthews
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of MX9203459A publication Critical patent/MX9203459A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
MX9203459A 1988-11-15 1992-06-26 Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina. MX9203459A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27147988A 1988-11-15 1988-11-15
US56347090A 1990-08-07 1990-08-07

Publications (1)

Publication Number Publication Date
MX9203459A true MX9203459A (es) 1992-08-01

Family

ID=26954941

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9203459A MX9203459A (es) 1988-11-15 1992-06-26 Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.

Country Status (2)

Country Link
US (3) US5378693A (es)
MX (1) MX9203459A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607925A (en) * 1988-11-15 1997-03-04 Merrell Pharmaceuticals Inc. Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides
MX9203459A (es) * 1988-11-15 1992-08-01 Merrell Pharma Inc Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
US5616702A (en) * 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5696097A (en) * 1993-03-18 1997-12-09 Yamasa Corporation Antineoplastic 5'-diacylglycerylphosphatidyl-2-deoxy-2'-methylenylcytidines and method of making
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
SE521031C2 (sv) * 1999-05-05 2003-09-23 Srinivas Uppugunduri Nya specifika inhibitorer av akut och kronisk inflammation
WO2001091731A1 (en) * 2000-06-02 2001-12-06 Matrix Pharmaceutical, Inc. Pharmaceutical compositions of 2'-deoxy-2'-(fluoromethylene)cytidine
CA2410589A1 (en) * 2000-06-02 2001-12-06 Richard E. Jones Pharmaceutical compositions of 2'-deoxy-2'-(fluoromethylene)cytidine
CA2458408A1 (en) 2001-08-24 2003-03-06 Koronis Pharmaceuticals, Inc. Mutagenic nucleoside analogs for the treatment of viral disease
CN100389119C (zh) * 2004-10-27 2008-05-21 北京东华康明生物科技有限公司 （反式）-2-脱氧-2-（氟亚甲基）-4-r酰胞苷化合物及其制备方法
BR112014014740B1 (pt) 2011-12-22 2021-08-24 Alios Biopharma, Inc Compostos de nucleosídeos, nucleotídeos e análogos destes, seu uso e composição farmacêutica
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
ES2671478T3 (es) 2012-08-31 2018-06-06 Novartis Ag Derivados de 2'-etinil nucleósidos para el tratamiento de infecciones virales

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113851A (en) * 1965-05-29 1968-05-15 Upjohn Co Decoyinine derivatives
US3472837A (en) * 1966-10-10 1969-10-14 Syntex Corp Unsaturated nucleosides and process for their preparation
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
MX9203459A (es) * 1988-11-15 1992-08-01 Merrell Pharma Inc Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
US5616702A (en) * 1988-11-15 1997-04-01 Merrell Pharmaceuticals Inc. 2-'-ethenylidene cytidine, uridine and guanosine derivatives

Also Published As

Publication number Publication date
US20040063659A1 (en) 2004-04-01
US20030109484A1 (en) 2003-06-12
US5378693A (en) 1995-01-03

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