DE3783751D1 - Glyzirrhetinsaeure-derivate und ihre anwendung. - Google Patents

Glyzirrhetinsaeure-derivate und ihre anwendung.

Info

Publication number
DE3783751D1
DE3783751D1 DE8787117324T DE3783751T DE3783751D1 DE 3783751 D1 DE3783751 D1 DE 3783751D1 DE 8787117324 T DE8787117324 T DE 8787117324T DE 3783751 T DE3783751 T DE 3783751T DE 3783751 D1 DE3783751 D1 DE 3783751D1
Authority
DE
Germany
Prior art keywords
glyzirrhetinic
acid derivatives
derivatives
acid
glyzirrhetinic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787117324T
Other languages
English (en)
Other versions
DE3783751T2 (de
Inventor
Ltd Kurono
Ltd Unno
Ltd Kimura
Ltd Oka
Ltd Hasegawa
Ltd Ikeda
Ltd Kuboyama
Ltd Ito
Ltd Sawai
Shunsuke Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanwa Kagaku Kenkyusho Co Ltd
Original Assignee
Sanwa Kagaku Kenkyusho Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanwa Kagaku Kenkyusho Co Ltd filed Critical Sanwa Kagaku Kenkyusho Co Ltd
Application granted granted Critical
Publication of DE3783751D1 publication Critical patent/DE3783751D1/de
Publication of DE3783751T2 publication Critical patent/DE3783751T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8787117324T 1986-11-28 1987-11-24 Glyzirrhetinsaeure-derivate und ihre anwendung. Expired - Fee Related DE3783751T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61281975A JPS63135351A (ja) 1986-11-28 1986-11-28 グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤

Publications (2)

Publication Number Publication Date
DE3783751D1 true DE3783751D1 (de) 1993-03-04
DE3783751T2 DE3783751T2 (de) 1993-05-13

Family

ID=17646505

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787117324T Expired - Fee Related DE3783751T2 (de) 1986-11-28 1987-11-24 Glyzirrhetinsaeure-derivate und ihre anwendung.

Country Status (4)

Country Link
US (1) US4871740A (de)
EP (1) EP0272478B1 (de)
JP (1) JPS63135351A (de)
DE (1) DE3783751T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356880A (en) * 1991-05-30 1994-10-18 Sanwa Kagaku Kenkyusho Co., Ltd. Glycyrrhetinic acid derivatives
WO1997003088A1 (fr) * 1995-07-07 1997-01-30 Meiji Seika Kabushiki Kaisha Derives triterpenes et medicament pour les maladies du foie
US7151082B2 (en) * 1999-02-11 2006-12-19 The Feinstein Institute For Medical Research Antagonists of HMG1 for treating inflammatory conditions
US6303321B1 (en) * 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
GB0105772D0 (en) * 2001-03-08 2001-04-25 Sterix Ltd Use
US7304034B2 (en) * 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7696169B2 (en) * 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
CA2882022A1 (en) * 2003-09-11 2005-03-24 Walter Newman Monoclonal antibodies against hmgb1
WO2007084253A2 (en) * 2005-11-28 2007-07-26 Medimmune, Inc. High affinity antibodies against hmgb1 and methods of use thereof
EP1909834A2 (de) * 2005-07-18 2008-04-16 Critical Therapeutics, Inc. Verwendung von hmgb1-antagonisten zur behandlung von entzündungskrankheiten
GB0604899D0 (en) * 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
CN101899081B (zh) * 2009-05-31 2012-09-05 江苏正大天晴药业股份有限公司 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物
CN109535219A (zh) * 2018-12-24 2019-03-29 锦州医科大学 18β-甘草次酸的哌嗪酰胺衍生物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3070623A (en) * 1957-07-16 1962-12-25 Biorex Laboratories Ltd Pharmacological compounds
US3070624A (en) * 1960-03-04 1962-12-25 Biorex Laboratories Ltd Glycyrrhetinic acid dialkylaminoalkyl esters
DE1248038B (de) * 1965-02-11 1967-08-24 Biorex Laboratories Ltd Verfahren zur Herstellung von Glycyrrhetinsaeure- und Oleanolsaeureamid sowie Derivaten derselben
GB1255098A (en) * 1969-07-28 1971-11-24 Biorex Laboratories Ltd Derivatives of glycyrrhetinic acid
US3734944A (en) * 1970-05-15 1973-05-22 Biorex Laboratories Ltd Glycyrrhetinic acid esters
US3814766A (en) * 1971-11-03 1974-06-04 Pfizer 11-deoxoglycyrrhetinic acid piperazides useful as antiulcer agents
GB1475075A (en) * 1974-09-11 1977-06-01 Biorex Laboratories Ltd Derivatives of glycyrrhetinic and oleanolic acids
JPS588044A (ja) * 1981-07-06 1983-01-18 Maruzen Seiyaku Kk １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬

Also Published As

Publication number Publication date
US4871740A (en) 1989-10-03
DE3783751T2 (de) 1993-05-13
EP0272478B1 (de) 1993-01-20
JPS63135351A (ja) 1988-06-07
EP0272478A1 (de) 1988-06-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee