DE3874763D1 - In 14- und 15-stellung substituierte lanosterole und ihre anwendung als hypocholesterolemische mittel. - Google Patents

In 14- und 15-stellung substituierte lanosterole und ihre anwendung als hypocholesterolemische mittel.

Info

Publication number
DE3874763D1
DE3874763D1 DE8888101139T DE3874763T DE3874763D1 DE 3874763 D1 DE3874763 D1 DE 3874763D1 DE 8888101139 T DE8888101139 T DE 8888101139T DE 3874763 T DE3874763 T DE 3874763T DE 3874763 D1 DE3874763 D1 DE 3874763D1
Authority
DE
Germany
Prior art keywords
lanosterols
substituted
positions
hypocholesterolemic agents
hypocholesterolemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888101139T
Other languages
English (en)
Other versions
DE3874763T2 (de
Inventor
James Leroy Gaylor
Robert Paul Johnson
Soo Sung Ko
Ronald Louis Magolda
Simon Hendrik Stam
James Michael Trzaskos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of DE3874763D1 publication Critical patent/DE3874763D1/de
Publication of DE3874763T2 publication Critical patent/DE3874763T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8888101139T 1987-01-30 1988-01-27 In 14- und 15-stellung substituierte lanosterole und ihre anwendung als hypocholesterolemische mittel. Expired - Fee Related DE3874763T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US881287A 1987-01-30 1987-01-30
US9063487A 1987-08-28 1987-08-28

Publications (2)

Publication Number Publication Date
DE3874763D1 true DE3874763D1 (de) 1992-10-29
DE3874763T2 DE3874763T2 (de) 1993-04-01

Family

ID=26678653

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888101139T Expired - Fee Related DE3874763T2 (de) 1987-01-30 1988-01-27 In 14- und 15-stellung substituierte lanosterole und ihre anwendung als hypocholesterolemische mittel.

Country Status (17)

Country Link
EP (1) EP0276823B1 (de)
KR (1) KR880009037A (de)
AU (1) AU611882B2 (de)
CA (1) CA1328449C (de)
DE (1) DE3874763T2 (de)
DK (1) DK47788A (de)
ES (1) ES2046217T3 (de)
FI (1) FI880417A (de)
GR (1) GR3006422T3 (de)
HU (1) HUT49145A (de)
IE (1) IE59999B1 (de)
IL (1) IL85254A0 (de)
MY (1) MY102582A (de)
NO (1) NO880409L (de)
NZ (1) NZ223344A (de)
PT (1) PT86665B (de)
ZA (1) ZA88655B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023250A (en) * 1989-08-24 1991-06-11 Smithkline Beecham Corporation Steroidal 14α-carboxy-alkyl derivatives as regulators of HMG-COA reductase
US5219879A (en) * 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
US6093389A (en) * 1997-12-01 2000-07-25 American Cyanamid Company Methods and compositions for attracting and controlling termites
KR20010043558A (ko) * 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202891A (en) * 1977-05-16 1980-05-13 Kandutsch Andrew A 15-Oxygenated sterol compounds and the use of such compounds to inhibit the biosynthesis of sterols

Also Published As

Publication number Publication date
ES2046217T3 (es) 1994-02-01
PT86665B (pt) 1992-02-28
IE880241L (en) 1988-07-30
HUT49145A (en) 1989-08-28
GR3006422T3 (de) 1993-06-21
DK47788A (da) 1988-07-31
EP0276823A2 (de) 1988-08-03
PT86665A (pt) 1988-02-01
ZA88655B (en) 1989-09-27
EP0276823B1 (de) 1992-09-23
KR880009037A (ko) 1988-09-13
AU1117188A (en) 1988-08-04
NO880409D0 (no) 1988-01-29
NZ223344A (en) 1990-12-21
FI880417A (fi) 1988-07-31
IL85254A0 (en) 1988-07-31
IE59999B1 (en) 1994-05-18
DE3874763T2 (de) 1993-04-01
MY102582A (en) 1992-07-31
NO880409L (no) 1988-08-01
EP0276823A3 (en) 1989-01-25
DK47788D0 (da) 1988-01-29
FI880417A0 (fi) 1988-01-29
CA1328449C (en) 1994-04-12
AU611882B2 (en) 1991-06-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee