DE68929304T2 - Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel - Google Patents

Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel

Info

Publication number
DE68929304T2
DE68929304T2 DE1989629304 DE68929304T DE68929304T2 DE 68929304 T2 DE68929304 T2 DE 68929304T2 DE 1989629304 DE1989629304 DE 1989629304 DE 68929304 T DE68929304 T DE 68929304T DE 68929304 T2 DE68929304 T2 DE 68929304T2
Authority
DE
Germany
Prior art keywords
antiviral drugs
oligoribonucleotide derivatives
oligoribonucleotide
derivatives
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE1989629304
Other languages
English (en)
Other versions
DE68929304D1 (de
Inventor
Susumu Shibahara
Hirokazu Morisawa
Hideki Nakajima
Naoki Yamamoto
Sachiko Mukai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27564029&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68929304(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP1064058A external-priority patent/JP2976436B2/ja
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE68929304D1 publication Critical patent/DE68929304D1/de
Publication of DE68929304T2 publication Critical patent/DE68929304T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE1989629304 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel Expired - Lifetime DE68929304T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP10494388 1988-04-27
JP13896688 1988-06-06
JP16814288 1988-07-06
JP22788788 1988-09-12
JP23848188 1988-09-22
JP2437289 1989-02-02
JP1064058A JP2976436B2 (ja) 1988-04-27 1989-03-16 新規オリゴリボヌクレオチド誘導体及び抗ウイルス剤への使用

Publications (2)

Publication Number Publication Date
DE68929304D1 DE68929304D1 (de) 2001-07-19
DE68929304T2 true DE68929304T2 (de) 2002-04-25

Family

ID=27564029

Family Applications (5)

Application Number Title Priority Date Filing Date
DE1989627417 Expired - Lifetime DE68927417T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel
DE1989629361 Expired - Lifetime DE68929361T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989629304 Expired - Lifetime DE68929304T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral-Arzneimittel
DE1989629305 Expired - Lifetime DE68929305T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989629306 Expired - Lifetime DE68929306T2 (de) 1988-04-27 1989-04-13 H-Phosphonat Ribonucleotid-Derivate

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE1989627417 Expired - Lifetime DE68927417T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und ihre Anwendung als antivirale Mittel
DE1989629361 Expired - Lifetime DE68929361T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE1989629305 Expired - Lifetime DE68929305T2 (de) 1988-04-27 1989-04-13 Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE1989629306 Expired - Lifetime DE68929306T2 (de) 1988-04-27 1989-04-13 H-Phosphonat Ribonucleotid-Derivate

Country Status (2)

Country Link
EP (1) EP0339842B1 (de)
DE (5) DE68927417T2 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958013A (en) * 1989-06-06 1990-09-18 Northwestern University Cholesteryl modified oligonucleotides
DE69034150T2 (de) * 1989-10-24 2005-08-25 Isis Pharmaceuticals, Inc., Carlsbad 2'-Modifizierte Oligonukleotide
US5955589A (en) * 1991-12-24 1999-09-21 Isis Pharmaceuticals Inc. Gapped 2' modified oligonucleotides
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5623065A (en) * 1990-08-13 1997-04-22 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6034233A (en) * 1990-05-04 2000-03-07 Isis Pharmaceuticals Inc. 2'-O-alkylated oligoribonucleotides and phosphorothioate analogs complementary to portions of the HIV genome
US6262241B1 (en) 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
CA2089376C (en) 1990-08-13 2010-05-04 Phillip Dan Cook Sugar modified oligonucleotides that detect and modulate gene expression
CA2096658A1 (en) * 1990-11-20 1992-05-21 Hidehiko Furukawa Anti-sense nucleic acid derivative
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
US7015315B1 (en) * 1991-12-24 2006-03-21 Isis Pharmaceuticals, Inc. Gapped oligonucleotides
US6307040B1 (en) * 1992-03-05 2001-10-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US7119184B2 (en) 1991-08-12 2006-10-10 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US5525719A (en) * 1991-08-30 1996-06-11 Chemgenes Corporation N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives
ATE515510T1 (de) * 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc Durch dna-abschnitte unterbrochene modifizierte oligonukleotide
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5856455A (en) * 1991-12-24 1999-01-05 Isis Pharmaceuticals, Inc. Gapped 2'-modified oligonucleotides
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5652355A (en) * 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
US6346614B1 (en) 1992-07-23 2002-02-12 Hybridon, Inc. Hybrid oligonucleotide phosphorothioates
TW244371B (de) * 1992-07-23 1995-04-01 Tri Clover Inc
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
DE4427219A1 (de) * 1994-08-01 1996-02-08 Max Planck Gesellschaft Nukleinsäure zur Initiation der Aktivität von RNase H bzw. reverser Transkriptase
US6057153A (en) * 1995-01-13 2000-05-02 Yale University Stabilized external guide sequences
US6222025B1 (en) 1995-03-06 2001-04-24 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom
US6166197A (en) * 1995-03-06 2000-12-26 Isis Pharmaceuticals, Inc. Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
TR199801581T2 (xx) 1996-02-14 1998-10-21 Isis Pharmaceuticals, Inc. �ekerle de�i�tirilmi� bo�luklu oligon�kleotid'ler.
US5856099A (en) * 1996-05-21 1999-01-05 Isis Pharmaceuticals, Inc. Antisense compositions and methods for modulating type I interleukin-1 receptor expression
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6610478B1 (en) 1996-08-16 2003-08-26 Yale University Phenotypic conversion of cells mediated by external guide sequences
US6172217B1 (en) * 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US6127533A (en) * 1997-02-14 2000-10-03 Isis Pharmaceuticals, Inc. 2'-O-aminooxy-modified oligonucleotides
US6576752B1 (en) 1997-02-14 2003-06-10 Isis Pharmaceuticals, Inc. Aminooxy functionalized oligomers
US6172209B1 (en) 1997-02-14 2001-01-09 Isis Pharmaceuticals Inc. Aminooxy-modified oligonucleotides and methods for making same
US20030036516A1 (en) * 1997-09-10 2003-02-20 Sudhir Agrawal Method for using oligonucleotides having modified cpg dinucleotides
WO2004024919A1 (en) 2002-09-13 2004-03-25 Replicor, Inc. Non-sequence complementary antiviral oligonucleotides
EP2056845B1 (de) 2006-08-08 2017-10-11 Rheinische Friedrich-Wilhelms-Universität Bonn Struktur und verwendung von 5'-phosphat-oligonukleotiden
US7820810B2 (en) 2007-03-19 2010-10-26 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted purine nulceosides
JP5689413B2 (ja) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 平滑末端を有する５’三リン酸オリゴヌクレオチドおよびその使用
EP2508530A1 (de) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Reinigung von triphosphorylierten Oligonucleotiden mit Einfang-Tags
EP2712870A1 (de) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Neuartige RIG-I-Liganden und Herstellungsverfahren dafür
CN105283561A (zh) 2013-04-04 2016-01-27 佐治亚州立大学研究基金会公司 使用纳米粒子辅助信号放大的rna微芯片检测

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567892B1 (fr) * 1984-07-19 1989-02-17 Centre Nat Rech Scient Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
JPS61291595A (ja) * 1985-06-19 1986-12-22 Ajinomoto Co Inc ２′−ｏ−メチル化ｒｎａの製造法

Also Published As

Publication number Publication date
EP0339842A3 (de) 1994-03-09
DE68929305D1 (de) 2001-07-19
EP0339842B1 (de) 1996-11-06
DE68929361T2 (de) 2002-06-20
DE68927417T2 (de) 1997-03-20
EP0339842A2 (de) 1989-11-02
DE68927417D1 (de) 1996-12-12
DE68929305T2 (de) 2002-05-02
DE68929306T2 (de) 2002-05-02
DE68929306D1 (de) 2001-07-19
DE68929304D1 (de) 2001-07-19
DE68929361D1 (de) 2002-01-31

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Legal Events

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