DE69637363D1 - 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität - Google Patents

1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität

Info

Publication number
DE69637363D1
DE69637363D1 DE69637363T DE69637363T DE69637363D1 DE 69637363 D1 DE69637363 D1 DE 69637363D1 DE 69637363 T DE69637363 T DE 69637363T DE 69637363 T DE69637363 T DE 69637363T DE 69637363 D1 DE69637363 D1 DE 69637363D1
Authority
DE
Germany
Prior art keywords
inhibirent
cytokin
phenylalkenyl
pde
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69637363T
Other languages
English (en)
Other versions
DE69637363T2 (de
Inventor
Eddy Jean Freyne
Gaston Stanislas Diels
Jose Ignacio Andres-Gil
Francisco Javi Fernandez-Gadea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69637363D1 publication Critical patent/DE69637363D1/de
Application granted granted Critical
Publication of DE69637363T2 publication Critical patent/DE69637363T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69637363T 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibierender aktivität Expired - Lifetime DE69637363T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95200869 1995-04-06
EP95200869 1995-04-06
PCT/EP1996/001395 WO1996031486A1 (en) 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2-one derivatives having pde iv and cytokine inhibiting activity

Publications (2)

Publication Number Publication Date
DE69637363D1 true DE69637363D1 (de) 2008-01-24
DE69637363T2 DE69637363T2 (de) 2008-12-04

Family

ID=8220174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69637363T Expired - Lifetime DE69637363T2 (de) 1995-04-06 1996-03-28 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibierender aktivität

Country Status (16)

Country Link
US (1) US5952510A (de)
EP (1) EP0819123B1 (de)
JP (1) JP3963475B2 (de)
KR (1) KR100400161B1 (de)
CN (1) CN1068590C (de)
AR (1) AR003412A1 (de)
AT (1) ATE380794T1 (de)
AU (1) AU703235B2 (de)
CA (1) CA2216546C (de)
DE (1) DE69637363T2 (de)
ES (1) ES2297837T3 (de)
IL (1) IL117808A (de)
MY (1) MY113446A (de)
TW (1) TW424087B (de)
WO (1) WO1996031486A1 (de)
ZA (1) ZA962755B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2267322C (en) * 1996-10-02 2007-11-06 Janssen Pharmaceutica N.V. Pde iv inhibiting 2-cyanoiminoimidazole derivatives
NZ507022A (en) 1998-04-01 2002-06-28 Janssen Pharmaceutica Nv PDE IV inhibiting pyridine derivatives
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
GB0321754D0 (en) * 2003-09-17 2003-10-15 Smiths Group Plc Apparatus
JP2009525269A (ja) * 2006-01-30 2009-07-09 ユーロ−セルティーク エス．エイ． カルシウムチャネルブロッカーとしての環状尿素化合物
KR101713453B1 (ko) 2010-03-12 2017-03-07 오메로스 코포레이션 Pde10 억제제 및 관련 조성물 및 방법
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
AU2016250843A1 (en) 2015-04-24 2017-10-12 Omeros Corporation PDE10 inhibitors and related compositions and methods
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
JP7202184B2 (ja) * 2016-02-03 2023-01-11 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｎｒｆ２活性化化合物およびその使用
JP7106453B2 (ja) * 2016-02-03 2022-07-26 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｎｒｆ２活性化化合物およびその使用
DE102017127776A1 (de) 2017-11-24 2019-05-29 Henkel Ag & Co. Kgaa Hydrolyselabile Heterocyclen von Riechstoffketonen oder -aldehyden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551417A (en) * 1967-08-28 1970-12-29 Universal Oil Prod Co Pesticidal heterocyclic sulfides
US5143928A (en) * 1990-03-27 1992-09-01 Warner-Lambert Company 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents
JPH06501708A (ja) * 1990-11-06 1994-02-24 スミスクライン・ビーチャム・コーポレイション イミダゾリジノン化合物
WO1994012461A1 (en) * 1992-12-02 1994-06-09 Pfizer Inc. Catechol diethers as selective pdeiv inhibitors
GB9226830D0 (en) * 1992-12-23 1993-02-17 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
CA2150533A1 (en) * 1994-05-31 1995-12-01 Katsumi Itoh Production of optically active triazole compounds and their intermediates

Also Published As

Publication number Publication date
US5952510A (en) 1999-09-14
CA2216546C (en) 2009-01-06
AR003412A1 (es) 1998-08-05
MY113446A (en) 2002-02-28
KR19980703450A (ko) 1998-11-05
CN1181071A (zh) 1998-05-06
TW424087B (en) 2001-03-01
ES2297837T3 (es) 2008-05-01
EP0819123A1 (de) 1998-01-21
DE69637363T2 (de) 2008-12-04
JP3963475B2 (ja) 2007-08-22
AU5275696A (en) 1996-10-23
KR100400161B1 (ko) 2004-02-05
EP0819123B1 (de) 2007-12-12
WO1996031486A1 (en) 1996-10-10
CN1068590C (zh) 2001-07-18
IL117808A (en) 2001-01-11
ZA962755B (en) 1997-10-06
IL117808A0 (en) 1996-08-04
AU703235B2 (en) 1999-03-18
JPH11503137A (ja) 1999-03-23
ATE380794T1 (de) 2007-12-15
CA2216546A1 (en) 1996-10-10

Similar Documents

Publication Publication Date Title
DE69619661D1 (de) 1,3-dihydro-1-(phenylalkyl)-2h-imidazol-2-on-derivate mit pde iv-und cytokin-inhibisender aktivität
DE68929305D1 (de) Oligoribonukleotid-Derivate und Verwendung davon als Antiviral Arzneimittel
DE68921469D1 (de) Peptidderivate und deren verwendung.
NL350016I1 (nl) 3-Aryl-4-hydroxy-delta#3-dihydrofuranon-en 3-aryl-4-hydroxy-delta#3-dihydrothiofenon-derivaten.
ATE243708T1 (de) Substituierte imidazolidinderivate, ihre herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE68910113D1 (de) Wachstuminhibierendes mittel und dessen verwendung.
DE69637363D1 (de) 1,3-dihydro-1-(phenylalkenyl)-2h-imidazol-2 on-derivate mit pde iv und cytokin-inhibirendes aktivität
DE69424051D1 (de) Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivität
DK0562583T3 (da) Hidtil ukendte alkylendiammoniumdiclavulanatderivater, fremgangsmåde til fremstilling deraf samt anvendelse deraf
NO905485L (no) Benzazepin- og benzotiazepin-derivater.
DE68922374D1 (de) Cyclische Amit-Derivate und Herbizide.
MX9203459A (es) Nuevos derivados de 2'-halometilideno, 2'-etenilideno y 2'-etinilcitidina, uridina y guanosina.
ATE111477T1 (de) 2'-halomethyliden, 2'-ethenyliden und 2'-ethynyl- adenosinderivate.
DE69009122D1 (de) Aufwärts und abwärts Zerhacker.
MA22981A1 (fr) Derives de piperidine, leur preparation et leur application en therapeutique.
DE69635224D1 (de) 1,3-dihydro-2h-imidazol-2-on-derivate mit pdeiv und cytokin inhibierender aktivität
DE69022936D1 (de) Beschleunigungsmessaufnehmer und Beschleunigungsmesssystem.
DE68906340D1 (de) Tetrahydronaphthalin und indan-derivate.
DE68919512D1 (de) Chinoxalin-Derivate und antiulzerierendes Mittel.
DE59310257D1 (de) 5-Spiro-substituierte 1-H-3-Aryl-pyrrolidin-2,4-dion-Derivate als Herbizide, Insektizide und Akarizide
DE68919507D1 (de) 2-Pyridylmethylthio-Derivate und antiulzerierendes Mittel.
DE69521347D1 (de) Ketonitrilderivate, antibaktrielle mittel und sie enthaltende arzneimittel
ATE104289T1 (de) Aminoethylthiazole und aminoethyloxazol-derivate.
IT1286509B1 (it) Derivati 2, 3, 4, 7-tetraidropiridoindazolo-(1,4)benzodiazepinici aventi attivita' antitumorale
ITMI922071A0 (it) Derivati xantonici, loro preparazione ed attivita'

Legal Events

Date Code Title Description
8364 No opposition during term of opposition