DE69424051D1 - Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivität - Google Patents
Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivitätInfo
- Publication number
- DE69424051D1 DE69424051D1 DE69424051T DE69424051T DE69424051D1 DE 69424051 D1 DE69424051 D1 DE 69424051D1 DE 69424051 T DE69424051 T DE 69424051T DE 69424051 T DE69424051 T DE 69424051T DE 69424051 D1 DE69424051 D1 DE 69424051D1
- Authority
- DE
- Germany
- Prior art keywords
- antimicrobe
- cancer
- rapamycin derivative
- immunomodulative
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939315914A GB9315914D0 (en) | 1993-07-31 | 1993-07-31 | Novel compound |
PCT/GB1994/001600 WO1995004060A1 (en) | 1993-07-31 | 1994-07-25 | Rapamycin derivative with antimicrobial, anticancer and immunomodulation activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69424051D1 true DE69424051D1 (de) | 2000-05-25 |
DE69424051T2 DE69424051T2 (de) | 2000-09-14 |
Family
ID=10739787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69424051T Expired - Fee Related DE69424051T2 (de) | 1993-07-31 | 1994-07-25 | Rapamycin-derivat mit antimikrobe, antikrebs und immunomodulatorischer aktivität |
Country Status (6)
Country | Link |
---|---|
US (1) | US5712129A (de) |
EP (1) | EP0711297B1 (de) |
JP (1) | JPH09501563A (de) |
DE (1) | DE69424051T2 (de) |
GB (1) | GB9315914D0 (de) |
WO (1) | WO1995004060A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
EP0937082A2 (de) | 1996-07-12 | 1999-08-25 | Ariad Pharmaceuticals, Inc. | Nicht immunhemmende antifungale rapaloge |
US6486892B1 (en) * | 1999-04-07 | 2002-11-26 | Joseph L. Stern | System and method for accessing, manipulating and viewing internet and non-internet related information and for controlling networked devices |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
CA2383451A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
EP2277898A3 (de) | 2002-07-16 | 2011-06-01 | Biotica Technology Limited | Rapamycinähnliche Substanzen |
AU2003293529A1 (en) | 2002-12-16 | 2004-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
GB0504994D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
GB0504995D0 (en) * | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Use of a compound |
US20100061994A1 (en) * | 2005-03-11 | 2010-03-11 | Rose Mary Sheridan | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
WO2009089549A1 (en) | 2008-01-11 | 2009-07-16 | Massachusetts Eye & Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
US9083932B2 (en) | 2009-03-25 | 2015-07-14 | Eloy Technology, Llc | Method and system for providing information from a program guide |
US9445158B2 (en) | 2009-11-06 | 2016-09-13 | Eloy Technology, Llc | Distributed aggregated content guide for collaborative playback session |
BR112014011645A2 (pt) | 2011-11-15 | 2017-05-02 | Novartis Ag | combinação de um inibidor da fosfoinositida 3-quinase e um modulador da quinase janus 2-transdutor de sinal e ativador da via de transcrição 5 |
WO2014006115A1 (en) | 2012-07-06 | 2014-01-09 | Novartis Ag | Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction |
CN105283553B (zh) | 2013-06-11 | 2021-06-25 | 克隆技术实验室有限公司 | 蛋白质富集的微泡及其制备和使用方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US5776943A (en) * | 1991-05-14 | 1998-07-07 | American Home Products Corporation | Rapamycin metabolites |
US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
ES2258763T3 (es) * | 1992-10-13 | 2006-09-01 | Wyeth | Carbamatos de rapamicina. |
US5310903A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | Imidazolidyl rapamycin derivatives |
US5310901A (en) * | 1993-03-05 | 1994-05-10 | Merck & Co., Inc. | O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives |
-
1993
- 1993-07-31 GB GB939315914A patent/GB9315914D0/en active Pending
-
1994
- 1994-07-25 JP JP7505641A patent/JPH09501563A/ja active Pending
- 1994-07-25 DE DE69424051T patent/DE69424051T2/de not_active Expired - Fee Related
- 1994-07-25 EP EP94921720A patent/EP0711297B1/de not_active Expired - Lifetime
- 1994-07-25 WO PCT/GB1994/001600 patent/WO1995004060A1/en active IP Right Grant
- 1994-07-25 US US08/591,457 patent/US5712129A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH09501563A (ja) | 1997-02-18 |
GB9315914D0 (en) | 1993-09-15 |
EP0711297A1 (de) | 1996-05-15 |
DE69424051T2 (de) | 2000-09-14 |
WO1995004060A1 (en) | 1995-02-09 |
EP0711297B1 (de) | 2000-04-19 |
US5712129A (en) | 1998-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |