DE69332484D1 - Rapamycinderivate - Google Patents

Rapamycinderivate

Info

Publication number
DE69332484D1
DE69332484D1 DE69332484T DE69332484T DE69332484D1 DE 69332484 D1 DE69332484 D1 DE 69332484D1 DE 69332484 T DE69332484 T DE 69332484T DE 69332484 T DE69332484 T DE 69332484T DE 69332484 D1 DE69332484 D1 DE 69332484D1
Authority
DE
Germany
Prior art keywords
rapamycin derivatives
rapamycin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332484T
Other languages
English (en)
Other versions
DE69332484T2 (de
Inventor
Alan Holt
Ignacio Luengo
Walter Rozamus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Application granted granted Critical
Publication of DE69332484D1 publication Critical patent/DE69332484D1/de
Publication of DE69332484T2 publication Critical patent/DE69332484T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69332484T 1992-07-17 1993-07-16 Rapamycinderivate Expired - Fee Related DE69332484T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91514592A 1992-07-17 1992-07-17
PCT/US1993/006679 WO1994002485A1 (en) 1992-07-17 1993-07-16 Rapamycin derivatives

Publications (2)

Publication Number Publication Date
DE69332484D1 true DE69332484D1 (de) 2002-12-19
DE69332484T2 DE69332484T2 (de) 2003-07-10

Family

ID=25435295

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332484T Expired - Fee Related DE69332484T2 (de) 1992-07-17 1993-07-16 Rapamycinderivate

Country Status (9)

Country Link
US (1) US5648361A (de)
EP (1) EP0650489B1 (de)
JP (1) JPH07509247A (de)
CN (1) CN1087911A (de)
AU (1) AU4680093A (de)
DE (1) DE69332484T2 (de)
MX (1) MX9304360A (de)
WO (1) WO1994002485A1 (de)
ZA (1) ZA935111B (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
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US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
DE19549794B4 (de) * 1994-10-26 2009-07-30 Novartis Ag Pharmazeutische Zusammensetzungen
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
EP0937082A2 (de) 1996-07-12 1999-08-25 Ariad Pharmaceuticals, Inc. Nicht immunhemmende antifungale rapaloge
JP2001500126A (ja) * 1996-09-09 2001-01-09 アメリカン・ホーム・プロダクツ・コーポレイション アルキル化ラパマイシン誘導体
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
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CA2359244C (en) 1999-01-13 2013-10-08 Bayer Corporation .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
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WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
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US7160867B2 (en) * 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
PT1626714E (pt) 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
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US8021849B2 (en) * 2004-11-05 2011-09-20 Siemens Healthcare Diagnostics Inc. Methods and kits for the determination of sirolimus in a sample
DK1828202T3 (da) 2004-12-20 2012-05-07 Wyeth Llc Rapamycinanaloge samt deres anvendelse ved behandling af neurologiske, proliferative og inflammatoriske lidelser
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WO2013192367A1 (en) 2012-06-22 2013-12-27 Novartis Ag Neuroendocrine tumor treatment
US20150224190A1 (en) 2012-07-06 2015-08-13 Mohamed Bentires-Alj Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the IL-8/CXCR interaction
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ZA935110B (en) * 1992-07-17 1994-02-04 Smithkline Beecham Corp Rapamycin derivatives
GB9221220D0 (en) * 1992-10-09 1992-11-25 Sandoz Ag Organic componds

Also Published As

Publication number Publication date
JPH07509247A (ja) 1995-10-12
ZA935111B (en) 1994-02-04
MX9304360A (es) 1994-04-29
EP0650489A1 (de) 1995-05-03
AU4680093A (en) 1994-02-14
EP0650489B1 (de) 2002-11-13
DE69332484T2 (de) 2003-07-10
WO1994002485A1 (en) 1994-02-03
CN1087911A (zh) 1994-06-15
EP0650489A4 (de) 1995-06-14
US5648361A (en) 1997-07-15

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