DK0731078T3 - Terpenquinon med antitumoraktivitet - Google Patents
Terpenquinon med antitumoraktivitetInfo
- Publication number
- DK0731078T3 DK0731078T3 DK95926978T DK95926978T DK0731078T3 DK 0731078 T3 DK0731078 T3 DK 0731078T3 DK 95926978 T DK95926978 T DK 95926978T DK 95926978 T DK95926978 T DK 95926978T DK 0731078 T3 DK0731078 T3 DK 0731078T3
- Authority
- DK
- Denmark
- Prior art keywords
- terpenquinone
- antitumor activity
- antitumor
- activity
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
- C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
- C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/35—Unsaturated compounds having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9401697A ES2083924B1 (es) | 1994-08-01 | 1994-08-01 | Terpeno-quinonas con actividad tumoral. |
| ES09500817A ES2100124B1 (es) | 1994-08-01 | 1995-04-27 | Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral. |
| PCT/ES1995/000096 WO1996004230A1 (es) | 1994-08-01 | 1995-08-01 | Terpeno-quinona con actividad antitumoral |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0731078T3 true DK0731078T3 (da) | 2002-08-19 |
Family
ID=26154811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95926978T DK0731078T3 (da) | 1994-08-01 | 1995-08-01 | Terpenquinon med antitumoraktivitet |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5744623A (da) |
| EP (1) | EP0731078B1 (da) |
| JP (1) | JP3927232B2 (da) |
| CA (1) | CA2173157A1 (da) |
| DE (1) | DE69525926T2 (da) |
| DK (1) | DK0731078T3 (da) |
| ES (1) | ES2100124B1 (da) |
| WO (1) | WO1996004230A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000061536A2 (en) * | 1999-04-14 | 2000-10-19 | Globoasia, L.L.C. | Synthesis and pharmaceuticals of novel 9-substituted-1,5-dichloroanthracene analogs |
| US6828347B2 (en) | 2002-11-06 | 2004-12-07 | Illinois Institute Of Technology | Anti-viral multi-quinone compounds and regiospecific synthesis thereof |
| CN105111096B (zh) * | 2015-08-21 | 2017-03-08 | 中国人民解放军第二军医大学 | 具有显著选择性细胞毒活性的一种醌类衍生物及其制备方法和用途 |
| KR101674622B1 (ko) | 2016-07-07 | 2016-11-09 | 국민대학교산학협력단 | 세스퀴테르펜 유도체의 신규한 용도 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE34414E (en) * | 1982-10-20 | 1993-10-19 | Takeda Chemical Industries, Ltd. | Physiologically active substance P-23924, its production and use |
| US4946869A (en) * | 1986-01-17 | 1990-08-07 | Merz And Co. Gmbh & Co. | Avarol, process for its production, pharmaceutical compositions thereof, and antiviral use of the same |
| US5082865A (en) * | 1986-01-17 | 1992-01-21 | Mueller Werner E G | Avarol and its production and use as an antitumor agent (I) |
| JPH0730217B2 (ja) * | 1986-05-08 | 1995-04-05 | 住友化学工業株式会社 | 熱可塑性エラストマ−組成物 |
| US4786652A (en) * | 1987-03-09 | 1988-11-22 | Syntex (U.S.A.) Inc. | Naphthalene anti-psoriatic agents |
| US5206268A (en) * | 1988-08-16 | 1993-04-27 | Burroughs Wellcome Co. | Medicaments |
| DE4325259C2 (de) * | 1993-07-28 | 1995-07-20 | Igus Gmbh | Energieführungskette |
-
1995
- 1995-04-27 ES ES09500817A patent/ES2100124B1/es not_active Expired - Fee Related
- 1995-08-01 US US08/624,593 patent/US5744623A/en not_active Expired - Fee Related
- 1995-08-01 DK DK95926978T patent/DK0731078T3/da active
- 1995-08-01 DE DE69525926T patent/DE69525926T2/de not_active Expired - Fee Related
- 1995-08-01 WO PCT/ES1995/000096 patent/WO1996004230A1/es active IP Right Grant
- 1995-08-01 EP EP95926978A patent/EP0731078B1/en not_active Expired - Lifetime
- 1995-08-01 CA CA002173157A patent/CA2173157A1/en not_active Abandoned
- 1995-08-01 JP JP50622696A patent/JP3927232B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0731078B1 (en) | 2002-03-20 |
| WO1996004230A1 (es) | 1996-02-15 |
| ES2100124B1 (es) | 1998-04-01 |
| US5744623A (en) | 1998-04-28 |
| DE69525926T2 (de) | 2002-10-31 |
| CA2173157A1 (en) | 1996-02-15 |
| JPH10502094A (ja) | 1998-02-24 |
| EP0731078A1 (en) | 1996-09-11 |
| ES2100124A1 (es) | 1997-06-01 |
| DE69525926D1 (de) | 2002-04-25 |
| JP3927232B2 (ja) | 2007-06-06 |
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