ES2100124B1 - Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral. - Google Patents

Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral.

Info

Publication number
ES2100124B1
ES2100124B1 ES09500817A ES9500817A ES2100124B1 ES 2100124 B1 ES2100124 B1 ES 2100124B1 ES 09500817 A ES09500817 A ES 09500817A ES 9500817 A ES9500817 A ES 9500817A ES 2100124 B1 ES2100124 B1 ES 2100124B1
Authority
ES
Spain
Prior art keywords
quinonas
terpeno
improvements introduced
antitumoral activity
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09500817A
Other languages
English (en)
Other versions
ES2100124A1 (es
Inventor
Escobar Marina Gordaliza
Del Corral Santana Jose Miguel
Bujanda M Del Mar Mahiques
Feliciano Martin Arturo San
Gravalos M Dolores Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9401697A external-priority patent/ES2083924B1/es
Application filed by Pharmamar SA filed Critical Pharmamar SA
Priority to ES09500817A priority Critical patent/ES2100124B1/es
Priority to DE69525926T priority patent/DE69525926T2/de
Priority to US08/624,593 priority patent/US5744623A/en
Priority to PCT/ES1995/000096 priority patent/WO1996004230A1/es
Priority to EP95926978A priority patent/EP0731078B1/en
Priority to DK95926978T priority patent/DK0731078T3/da
Priority to CA002173157A priority patent/CA2173157A1/en
Priority to JP50622696A priority patent/JP3927232B2/ja
Publication of ES2100124A1 publication Critical patent/ES2100124A1/es
Publication of ES2100124B1 publication Critical patent/ES2100124B1/es
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PERFECCIONAMIENTOS INTRODUCIDOS EN LA P.I.9401697 TERPENO-QUINONAS CON ACTIVIDAD ANTITUMORAL, DEFINIDAS A PARTIR DE UNA REACCION DE CICLOCONDENSACION DE DIELS-ALDER, CONSIGUIENDOSE FAMILIAS O SERIES DE DICHOS COMPUESTOS DE NUEVA ESTRUCTURA QUE PRESENTAN ACTIVIDAD CITOTOXICA FRENTE A CULTIVOS CELULARES P-388, A 549, JT-29 Y MEL-28, ALCANZANDO NIVELES DE IC50 INFERIORES A 1 MICROGRAMO POR UNIDAD DE MILILITRO.
ES09500817A 1994-08-01 1995-04-27 Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral. Expired - Fee Related ES2100124B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES09500817A ES2100124B1 (es) 1994-08-01 1995-04-27 Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral.
EP95926978A EP0731078B1 (en) 1994-08-01 1995-08-01 Terpene-quinone with antitumor activity
US08/624,593 US5744623A (en) 1994-08-01 1995-08-01 Terpene-quinones with antitumour activity
PCT/ES1995/000096 WO1996004230A1 (es) 1994-08-01 1995-08-01 Terpeno-quinona con actividad antitumoral
DE69525926T DE69525926T2 (de) 1994-08-01 1995-08-01 Terpenchinon mit antitumor-aktivität
DK95926978T DK0731078T3 (da) 1994-08-01 1995-08-01 Terpenquinon med antitumoraktivitet
CA002173157A CA2173157A1 (en) 1994-08-01 1995-08-01 Terpene-quinone with antitumor activity
JP50622696A JP3927232B2 (ja) 1994-08-01 1995-08-01 抗腫瘍作用を有するテルペン−キノン

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9401697A ES2083924B1 (es) 1994-08-01 1994-08-01 Terpeno-quinonas con actividad tumoral.
ES09500817A ES2100124B1 (es) 1994-08-01 1995-04-27 Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral.

Publications (2)

Publication Number Publication Date
ES2100124A1 ES2100124A1 (es) 1997-06-01
ES2100124B1 true ES2100124B1 (es) 1998-04-01

Family

ID=26154811

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09500817A Expired - Fee Related ES2100124B1 (es) 1994-08-01 1995-04-27 Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral.

Country Status (8)

Country Link
US (1) US5744623A (es)
EP (1) EP0731078B1 (es)
JP (1) JP3927232B2 (es)
CA (1) CA2173157A1 (es)
DE (1) DE69525926T2 (es)
DK (1) DK0731078T3 (es)
ES (1) ES2100124B1 (es)
WO (1) WO1996004230A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061536A2 (en) * 1999-04-14 2000-10-19 Globoasia, L.L.C. Synthesis and pharmaceuticals of novel 9-substituted-1,5-dichloroanthracene analogs
US6828347B2 (en) 2002-11-06 2004-12-07 Illinois Institute Of Technology Anti-viral multi-quinone compounds and regiospecific synthesis thereof
CN105111096B (zh) * 2015-08-21 2017-03-08 中国人民解放军第二军医大学 具有显著选择性细胞毒活性的一种醌类衍生物及其制备方法和用途
KR101674622B1 (ko) * 2016-07-07 2016-11-09 국민대학교산학협력단 세스퀴테르펜 유도체의 신규한 용도
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34414E (en) * 1982-10-20 1993-10-19 Takeda Chemical Industries, Ltd. Physiologically active substance P-23924, its production and use
US5082865A (en) * 1986-01-17 1992-01-21 Mueller Werner E G Avarol and its production and use as an antitumor agent (I)
US4946869A (en) * 1986-01-17 1990-08-07 Merz And Co. Gmbh & Co. Avarol, process for its production, pharmaceutical compositions thereof, and antiviral use of the same
JPH0730217B2 (ja) * 1986-05-08 1995-04-05 住友化学工業株式会社 熱可塑性エラストマ−組成物
US4786652A (en) * 1987-03-09 1988-11-22 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
DE4325259C2 (de) * 1993-07-28 1995-07-20 Igus Gmbh Energieführungskette

Also Published As

Publication number Publication date
ES2100124A1 (es) 1997-06-01
JP3927232B2 (ja) 2007-06-06
EP0731078A1 (en) 1996-09-11
DE69525926D1 (de) 2002-04-25
US5744623A (en) 1998-04-28
EP0731078B1 (en) 2002-03-20
CA2173157A1 (en) 1996-02-15
WO1996004230A1 (es) 1996-02-15
JPH10502094A (ja) 1998-02-24
DK0731078T3 (da) 2002-08-19
DE69525926T2 (de) 2002-10-31

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