DE69525926D1 - Terpenchinon mit antitumor-aktivität - Google Patents

Terpenchinon mit antitumor-aktivität

Info

Publication number
DE69525926D1
DE69525926D1 DE69525926T DE69525926T DE69525926D1 DE 69525926 D1 DE69525926 D1 DE 69525926D1 DE 69525926 T DE69525926 T DE 69525926T DE 69525926 T DE69525926 T DE 69525926T DE 69525926 D1 DE69525926 D1 DE 69525926D1
Authority
DE
Germany
Prior art keywords
terpenchinone
antitumor activity
antitumor
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69525926T
Other languages
English (en)
Other versions
DE69525926T2 (de
Inventor
Gravalos M Dolores Garcia
Escobar Marina Gordaliza
Del Corral Santana Jose Miguel
Bujanda M Del Mar Mahiques
Feliciano Martin Arturo San
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES9401697A external-priority patent/ES2083924B1/es
Application filed by Pharmamar SA filed Critical Pharmamar SA
Application granted granted Critical
Publication of DE69525926D1 publication Critical patent/DE69525926D1/de
Publication of DE69525926T2 publication Critical patent/DE69525926T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/647—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring
    • C07C49/653—Unsaturated compounds containing a keto groups being part of a ring having unsaturation outside the ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/10—Quinones the quinoid structure being part of a condensed ring system containing two rings
    • C07C50/14—Quinones the quinoid structure being part of a condensed ring system containing two rings with unsaturation outside the ring system, e.g. vitamin K1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69525926T 1994-08-01 1995-08-01 Terpenchinon mit antitumor-aktivität Expired - Fee Related DE69525926T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES9401697A ES2083924B1 (es) 1994-08-01 1994-08-01 Terpeno-quinonas con actividad tumoral.
ES09500817A ES2100124B1 (es) 1994-08-01 1995-04-27 Perfeccionamientos introducidos en la p.i. 9401697 por terpeno-quinonas con actividad antitumoral.
PCT/ES1995/000096 WO1996004230A1 (es) 1994-08-01 1995-08-01 Terpeno-quinona con actividad antitumoral

Publications (2)

Publication Number Publication Date
DE69525926D1 true DE69525926D1 (de) 2002-04-25
DE69525926T2 DE69525926T2 (de) 2002-10-31

Family

ID=26154811

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69525926T Expired - Fee Related DE69525926T2 (de) 1994-08-01 1995-08-01 Terpenchinon mit antitumor-aktivität

Country Status (8)

Country Link
US (1) US5744623A (de)
EP (1) EP0731078B1 (de)
JP (1) JP3927232B2 (de)
CA (1) CA2173157A1 (de)
DE (1) DE69525926T2 (de)
DK (1) DK0731078T3 (de)
ES (1) ES2100124B1 (de)
WO (1) WO1996004230A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4220900A (en) * 1999-04-14 2000-11-14 Globoasia, L.L.C. Synthesis and pharmaceuticals of novel 9-substituted-1,5-dichloroanthracene analogs
US6828347B2 (en) 2002-11-06 2004-12-07 Illinois Institute Of Technology Anti-viral multi-quinone compounds and regiospecific synthesis thereof
CN105111096B (zh) * 2015-08-21 2017-03-08 中国人民解放军第二军医大学 具有显著选择性细胞毒活性的一种醌类衍生物及其制备方法和用途
KR101674622B1 (ko) 2016-07-07 2016-11-09 국민대학교산학협력단 세스퀴테르펜 유도체의 신규한 용도
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE34414E (en) * 1982-10-20 1993-10-19 Takeda Chemical Industries, Ltd. Physiologically active substance P-23924, its production and use
US4946869A (en) * 1986-01-17 1990-08-07 Merz And Co. Gmbh & Co. Avarol, process for its production, pharmaceutical compositions thereof, and antiviral use of the same
US5082865A (en) * 1986-01-17 1992-01-21 Mueller Werner E G Avarol and its production and use as an antitumor agent (I)
JPH0730217B2 (ja) * 1986-05-08 1995-04-05 住友化学工業株式会社 熱可塑性エラストマ−組成物
US4786652A (en) * 1987-03-09 1988-11-22 Syntex (U.S.A.) Inc. Naphthalene anti-psoriatic agents
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
DE4325259C2 (de) * 1993-07-28 1995-07-20 Igus Gmbh Energieführungskette

Also Published As

Publication number Publication date
ES2100124B1 (es) 1998-04-01
DE69525926T2 (de) 2002-10-31
JPH10502094A (ja) 1998-02-24
JP3927232B2 (ja) 2007-06-06
DK0731078T3 (da) 2002-08-19
US5744623A (en) 1998-04-28
EP0731078B1 (de) 2002-03-20
EP0731078A1 (de) 1996-09-11
WO1996004230A1 (es) 1996-02-15
ES2100124A1 (es) 1997-06-01
CA2173157A1 (en) 1996-02-15

Similar Documents

Publication Publication Date Title
DE69514471D1 (de) Digitalisiergerät mit Rauschverminderung
FI942119A0 (fi) Anordning i en gasblandare
DE69511918D1 (de) Kugellager
DE59502973D1 (de) Verbindungsanordnung
FI971278A (fi) Kasvainten vastaisia aineita
NO992103D0 (no) Dihydropyroner med forbedret antiviral aktivitet
DE69525926D1 (de) Terpenchinon mit antitumor-aktivität
DE69604385D1 (de) Isocumarine mit antitumorwirkung
DE69324681T2 (de) Entproteinisierung mit azlacton-gekoppelten funktionsträgern
DE29512247U1 (de) Büstenhalter mit verbesserter Stützwirkung
FI1516U1 (fi) Foerpackning foer i stapel anordnade smaoark
DE9400125U1 (de) Tisch-Fuß-Anordnung
FI962961A0 (fi) Telebetalningssystem i realtid
DE29520289U1 (de) Befestigung
KR950023844U (ko) 쎈추로
BR7402076U (pt) Trigol/circulo
KR960010567U (ko) 아암레스트
DE9405692U1 (de) Kochset mit Selbsthalterung
FI1376U1 (fi) Krokformigt roer
FI940841A0 (fi) Lockoeppnare foer konservburk med undertryck
KR960012685U (ko) 씨모오스 구조
KR960012134U (ko) 일면음반
DE9218427U1 (de) Diskette
KR950026931U (ko) 먹줄통
FI1418U1 (fi) Sopkaerlsutrustning foer montering i skaop

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: DERZEIT KEIN VERTRETER BESTELLT

8339 Ceased/non-payment of the annual fee