DE3582399D1 - Purin-derivate und ihre pharmazeutische verwendung. - Google Patents

Purin-derivate und ihre pharmazeutische verwendung.

Info

Publication number
DE3582399D1
DE3582399D1 DE8585111354T DE3582399T DE3582399D1 DE 3582399 D1 DE3582399 D1 DE 3582399D1 DE 8585111354 T DE8585111354 T DE 8585111354T DE 3582399 T DE3582399 T DE 3582399T DE 3582399 D1 DE3582399 D1 DE 3582399D1
Authority
DE
Germany
Prior art keywords
pharmaceutical use
purine derivatives
purine
derivatives
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585111354T
Other languages
English (en)
Inventor
Michael Raymond Harnden
Richard Lewis Jarvest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis International Pharmaceutical Ltd
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423833A external-priority patent/GB8423833D0/en
Priority claimed from GB858510331A external-priority patent/GB8510331D0/en
Priority claimed from GB858520618A external-priority patent/GB8520618D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3582399D1 publication Critical patent/DE3582399D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
DE8585111354T 1984-09-20 1985-09-09 Purin-derivate und ihre pharmazeutische verwendung. Expired - Lifetime DE3582399D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB848423833A GB8423833D0 (en) 1984-09-20 1984-09-20 Compounds
GB858510331A GB8510331D0 (en) 1985-04-23 1985-04-23 Compounds
GB858520618A GB8520618D0 (en) 1985-08-16 1985-08-16 Compounds

Publications (1)

Publication Number Publication Date
DE3582399D1 true DE3582399D1 (de) 1991-05-08

Family

ID=27262464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585111354T Expired - Lifetime DE3582399D1 (de) 1984-09-20 1985-09-09 Purin-derivate und ihre pharmazeutische verwendung.

Country Status (24)

Country Link
EP (1) EP0182024B1 (de)
JP (2) JPS6185388A (de)
KR (1) KR930006349B1 (de)
AT (1) AT389118B (de)
AU (1) AU589371B2 (de)
BG (1) BG61493B2 (de)
CA (1) CA1262899A (de)
CY (1) CY1747A (de)
CZ (1) CZ283721B6 (de)
DE (1) DE3582399D1 (de)
DK (1) DK167019B1 (de)
ES (1) ES8703876A1 (de)
FI (1) FI87564C (de)
GR (1) GR852272B (de)
HK (1) HK128693A (de)
HU (1) HU198934B (de)
IE (1) IE58141B1 (de)
MX (1) MX165116B (de)
MY (1) MY102473A (de)
NL (1) NL960006I1 (de)
NO (1) NO167572C (de)
NZ (1) NZ213528A (de)
PT (1) PT81160B (de)
WO (1) WO1987005604A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
GB8628826D0 (en) * 1986-12-02 1987-01-07 Beecham Group Plc Pharmaceutical products
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
ES2098219T3 (es) * 1987-08-01 1997-05-01 Beecham Group Plc Compuestos de purina y su preparacion.
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
JPH02247191A (ja) * 1989-02-02 1990-10-02 Merck & Co Inc 抗レトロウイルス剤としてのプリンおよびピリミジン非環状ヌクレオシドの環状モノホスフエート類
CA2009109A1 (en) * 1989-02-02 1990-08-02 John Hannah Antiviral acyclonucleosides and acyclonucleotides
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
GB9004647D0 (en) * 1990-03-01 1990-04-25 Beecham Group Plc Pharmaceuticals
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
GB9201961D0 (en) 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
IL111138A (en) * 1993-10-05 1997-04-15 Smithkline Beecham Plc Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
US6683084B1 (en) 1993-11-12 2004-01-27 Novartis International Pharmaceutical Ltd. Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323404D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9323403D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9407698D0 (en) 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
GB9504497D0 (en) * 1995-03-07 1995-04-26 Smithkline Beecham Plc Pharmaceuticals
GB9600847D0 (en) * 1996-01-16 1996-03-20 Smithkline Beecham Plc Pharmaceuticals
WO1997029108A1 (en) * 1996-02-07 1997-08-14 Smithkline Beecham Plc Famciclovir monohydrate
US7279483B2 (en) 1996-02-07 2007-10-09 Novartis Ag Famciclovir monohydrate
GR1002949B (el) * 1996-07-20 1998-07-29 Smithkline Beecham P.L.C. Φαρμακα
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
CA2251481A1 (en) 1997-11-12 1999-05-12 Junichi Yasuoka Purine derivatives having cyclopropane ring
GB9807116D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
SI20022A (sl) * 1998-07-29 2000-02-29 Kemijski inštitut Alkilno substituirani purinovi derivati in njihova priprava
EP1490090A4 (de) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Wirkstoff-abgabesystem und verfahren zum schutz und zur verabreichung von wirkstoffen
AU2003268213A1 (en) 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
PT1583542E (pt) 2003-01-14 2008-09-17 Gilead Sciences Inc Composições e métodos para terapia de combinação antiviral
AU2006230269A1 (en) 2005-03-30 2006-10-05 Novartis Ag Penciclovir or famciclovir for the treatment of recurrent genital herpes with a one-day application
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP3337512A1 (de) 2015-08-17 2018-06-27 Sanovel Ilac Sanayi ve Ticaret A.S. Topische antivirale zusammensetzung
US10364263B2 (en) * 2015-12-08 2019-07-30 Retrophin, Inc. Cyclic phosphates and cyclic phosphoramidates for the treatment of neurologic disorders
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE33654T1 (de) * 1982-10-14 1988-05-15 Wellcome Found Antivirale purinderivate.
EP0141927B1 (de) * 1983-08-18 1991-10-30 Beecham Group Plc Antivirale Guanin-Derivate
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
EP0152316B1 (de) * 1984-01-26 1989-07-26 Merck & Co. Inc. Substituierte Butylguanine und ihre Verwendung in antiviralen Zusammensetzungen

Also Published As

Publication number Publication date
NO167572C (no) 1991-11-20
BG61493B2 (bg) 1997-09-30
CY1747A (en) 1994-06-03
AU589371B2 (en) 1989-10-12
WO1987005604A1 (en) 1987-09-24
HU198934B (en) 1989-12-28
ES547128A0 (es) 1987-03-01
FI875059A0 (fi) 1987-11-16
PT81160B (pt) 1988-01-22
AU4756085A (en) 1986-03-27
ATA904286A (de) 1989-03-15
HK128693A (en) 1993-11-26
HUT47576A (en) 1989-03-28
MX165116B (es) 1992-10-27
NZ213528A (en) 1989-03-29
KR930006349B1 (ko) 1993-07-14
CA1262899A (en) 1989-11-14
NL960006I2 (nl) 1996-09-02
DK167019B1 (da) 1993-08-16
EP0182024B1 (de) 1991-04-03
DK424685A (da) 1986-03-21
IE58141B1 (en) 1993-07-14
ES8703876A1 (es) 1987-03-01
FI875059A (fi) 1987-11-16
EP0182024A3 (en) 1989-03-08
JPH0586792B2 (de) 1993-12-14
NO874764L (no) 1987-11-16
CZ283721B6 (cs) 1998-06-17
FI87564C (fi) 1993-01-25
JPH0625241A (ja) 1994-02-01
MY102473A (en) 1992-06-30
AT389118B (de) 1989-10-25
FI87564B (fi) 1992-10-15
EP0182024A2 (de) 1986-05-28
NO167572B (no) 1991-08-12
IE852307L (en) 1986-03-20
NL960006I1 (nl) 1996-09-02
JPS6185388A (ja) 1986-04-30
PT81160A (en) 1985-10-01
JPH0826021B2 (ja) 1996-03-13
CS391591A3 (en) 1992-05-13
DK424685D0 (da) 1985-09-18
GR852272B (de) 1986-01-21
NO874764D0 (no) 1987-11-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: FAMCICLOVIR; REGISTRATION NO/DATE: 30859.00.00, 30860.00.00; 19941117

Spc suppl protection certif: 195 75 014

Filing date: 19950515

V457 Spc granted

Free format text: PRODUCT NAME: FAMCICLOVIR; REGISTRATION NO/DATE: 30859.00.00, 30860.00.00; 19941117

Spc suppl protection certif: 195 75 014

Filing date: 19950515

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD., HAMILT

V464 Spc expired

Free format text: PRODUCT NAME: FAMCICLOVIR; REGISTRATION NO/DATE: 30859.00.00, 30860.00.00; 19941117

Spc suppl protection certif: 195 75 014

Filing date: 19950515