FI875059A - Foereningar. - Google Patents

Foereningar. Download PDF

Info

Publication number
FI875059A
FI875059A FI875059A FI875059A FI875059A FI 875059 A FI875059 A FI 875059A FI 875059 A FI875059 A FI 875059A FI 875059 A FI875059 A FI 875059A FI 875059 A FI875059 A FI 875059A
Authority
FI
Finland
Prior art keywords
phosphate
cyclic
group
relates
foereningar
Prior art date
Application number
FI875059A
Other languages
English (en)
Other versions
FI87564C (fi
FI875059A0 (fi
FI87564B (fi
Inventor
Michael Raymond Harnden
Richard Lewis Jarvest
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423833A external-priority patent/GB8423833D0/en
Priority claimed from GB858510331A external-priority patent/GB8510331D0/en
Priority claimed from GB858520618A external-priority patent/GB8520618D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of FI875059A publication Critical patent/FI875059A/fi
Publication of FI875059A0 publication Critical patent/FI875059A0/fi
Application granted granted Critical
Publication of FI87564B publication Critical patent/FI87564B/fi
Publication of FI87564C publication Critical patent/FI87564C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI875059A 1984-09-20 1987-11-16 Foerfarande foer framstaellning av ett terapeutiskt aktivt purinderivat FI87564C (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB848423833A GB8423833D0 (en) 1984-09-20 1984-09-20 Compounds
GB8423833 1984-09-20
GB858510331A GB8510331D0 (en) 1985-04-23 1985-04-23 Compounds
GB8510331 1985-04-23
GB858520618A GB8520618D0 (en) 1985-08-16 1985-08-16 Compounds
GB8520618 1985-08-16
PCT/GB1986/000153 WO1987005604A1 (en) 1984-09-20 1986-03-17 2-aminopurine derivatives and process for their preparation
GB8600153 1986-03-17

Publications (4)

Publication Number Publication Date
FI875059A true FI875059A (fi) 1987-11-16
FI875059A0 FI875059A0 (fi) 1987-11-16
FI87564B FI87564B (fi) 1992-10-15
FI87564C FI87564C (fi) 1993-01-25

Family

ID=27262464

Family Applications (1)

Application Number Title Priority Date Filing Date
FI875059A FI87564C (fi) 1984-09-20 1987-11-16 Foerfarande foer framstaellning av ett terapeutiskt aktivt purinderivat

Country Status (24)

Country Link
EP (1) EP0182024B1 (fi)
JP (2) JPS6185388A (fi)
KR (1) KR930006349B1 (fi)
AT (1) AT389118B (fi)
AU (1) AU589371B2 (fi)
BG (1) BG61493B2 (fi)
CA (1) CA1262899A (fi)
CY (1) CY1747A (fi)
CZ (1) CZ283721B6 (fi)
DE (1) DE3582399D1 (fi)
DK (1) DK167019B1 (fi)
ES (1) ES8703876A1 (fi)
FI (1) FI87564C (fi)
GR (1) GR852272B (fi)
HK (1) HK128693A (fi)
HU (1) HU198934B (fi)
IE (1) IE58141B1 (fi)
MX (1) MX165116B (fi)
MY (1) MY102473A (fi)
NL (1) NL960006I2 (fi)
NO (1) NO167572C (fi)
NZ (1) NZ213528A (fi)
PT (1) PT81160B (fi)
WO (1) WO1987005604A1 (fi)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8406538D0 (sv) * 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
GB8628826D0 (en) * 1986-12-02 1987-01-07 Beecham Group Plc Pharmaceutical products
ES2098219T3 (es) * 1987-08-01 1997-05-01 Beecham Group Plc Compuestos de purina y su preparacion.
US5175288A (en) * 1987-08-01 1992-12-29 Beecham Group P.L.C. Process for preparing purine derivatives and intermediates thereof
GB8817270D0 (en) * 1988-07-20 1988-08-24 Beecham Group Plc Novel process
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
CA2009109A1 (en) * 1989-02-02 1990-08-02 John Hannah Antiviral acyclonucleosides and acyclonucleotides
JPH02247191A (ja) * 1989-02-02 1990-10-02 Merck & Co Inc 抗レトロウイルス剤としてのプリンおよびピリミジン非環状ヌクレオシドの環状モノホスフエート類
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
GB8922076D0 (en) * 1989-09-28 1989-11-15 Beecham Group Plc Novel process
GB9004647D0 (en) * 1990-03-01 1990-04-25 Beecham Group Plc Pharmaceuticals
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
GB9201961D0 (en) 1992-01-30 1992-03-18 Smithkline Beecham Plc Pharmaceuticals
IL111138A (en) * 1993-10-05 1997-04-15 Smithkline Beecham Plc Pharmaceutical compositions comprising penciclovir and/or its bioprecursor and/or its derivatives for the treatment and prophylaxis of post-herpetic neuralgia
GB9326177D0 (en) * 1993-12-22 1994-02-23 Smithkline Beecham Plc Pharmaceuticals
US6124304A (en) * 1993-10-05 2000-09-26 Smithkline Beecham Plc Penciclovir for the treatment of zoster associated pain
GB9323403D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
US6683084B1 (en) 1993-11-12 2004-01-27 Novartis International Pharmaceutical Ltd. Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections
GB9323404D0 (en) * 1993-11-12 1994-01-05 Smithkline Beecham Plc Pharmaceuticals
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
DE4420751A1 (de) * 1994-06-15 1995-12-21 Basf Ag Verfahren zur Herstellung von enantiomerenreinen Lactamen
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
GB9504497D0 (en) * 1995-03-07 1995-04-26 Smithkline Beecham Plc Pharmaceuticals
GB9600847D0 (en) 1996-01-16 1996-03-20 Smithkline Beecham Plc Pharmaceuticals
US7279483B2 (en) 1996-02-07 2007-10-09 Novartis Ag Famciclovir monohydrate
EP0885223B1 (en) * 1996-02-07 2001-09-19 Novartis International Pharmaceutical Ltd. Pharmaceutical compositions comprising famciclovir monohydrate
GB9615253D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
AT412211B (de) * 1996-07-20 2004-11-25 Novartis Int Pharm Ltd Verfahren zur herstellung von penciclovir und famciclovir
GB9615276D0 (en) * 1996-07-20 1996-09-04 Smithkline Beecham Plc Pharmaceuticals
CA2251481A1 (en) * 1997-11-12 1999-05-12 Junichi Yasuoka Purine derivatives having cyclopropane ring
GB9807116D0 (en) 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
SI20022A (sl) * 1998-07-29 2000-02-29 Kemijski inštitut Alkilno substituirani purinovi derivati in njihova priprava
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
AU2003268213A1 (en) 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
ATE398455T1 (de) 2003-01-14 2008-07-15 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
AU2006230269A1 (en) 2005-03-30 2006-10-05 Novartis Ag Penciclovir or famciclovir for the treatment of recurrent genital herpes with a one-day application
GB2426247A (en) 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2017029298A1 (en) 2015-08-17 2017-02-23 Sanovel Ilac Sanayi Ve Ticaret A.S. A topical antiviral composition
KR20180094942A (ko) * 2015-12-08 2018-08-24 레트로핀, 인코포레이티드 신경질환의 치료를 위한 사이클릭 포스페이트 및 사이클릭 포스포아미데이트
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573540B2 (en) * 1982-10-14 1988-06-16 Wellcome Foundation Limited, The 6-hydrogen purine derivatives
AU577303B2 (en) * 1983-08-18 1988-09-22 Novartis International Pharmaceutical Ltd 9-substituted-2-amino purines
EP0141927B1 (en) * 1983-08-18 1991-10-30 Beecham Group Plc Antiviral guanine derivatives
DE3571810D1 (en) * 1984-01-26 1989-08-31 Merck & Co Inc Substituted butyl guanines and their utilization in antiviral compositions

Also Published As

Publication number Publication date
AU4756085A (en) 1986-03-27
HUT47576A (en) 1989-03-28
ATA904286A (de) 1989-03-15
GR852272B (fi) 1986-01-21
CY1747A (en) 1994-06-03
CZ283721B6 (cs) 1998-06-17
DK424685A (da) 1986-03-21
NZ213528A (en) 1989-03-29
JPH0625241A (ja) 1994-02-01
NO167572B (no) 1991-08-12
NO167572C (no) 1991-11-20
NO874764D0 (no) 1987-11-16
ES547128A0 (es) 1987-03-01
EP0182024A3 (en) 1989-03-08
JPS6185388A (ja) 1986-04-30
NO874764L (no) 1987-11-16
KR930006349B1 (ko) 1993-07-14
EP0182024B1 (en) 1991-04-03
JPH0826021B2 (ja) 1996-03-13
MX165116B (es) 1992-10-27
FI87564C (fi) 1993-01-25
EP0182024A2 (en) 1986-05-28
ES8703876A1 (es) 1987-03-01
IE852307L (en) 1986-03-20
NL960006I1 (nl) 1996-09-02
HU198934B (en) 1989-12-28
BG61493B2 (bg) 1997-09-30
CS391591A3 (en) 1992-05-13
DE3582399D1 (de) 1991-05-08
DK167019B1 (da) 1993-08-16
HK128693A (en) 1993-11-26
AU589371B2 (en) 1989-10-12
CA1262899A (en) 1989-11-14
FI875059A0 (fi) 1987-11-16
MY102473A (en) 1992-06-30
FI87564B (fi) 1992-10-15
NL960006I2 (nl) 1996-09-02
AT389118B (de) 1989-10-25
PT81160A (en) 1985-10-01
PT81160B (pt) 1988-01-22
WO1987005604A1 (en) 1987-09-24
IE58141B1 (en) 1993-07-14
JPH0586792B2 (fi) 1993-12-14
DK424685D0 (da) 1985-09-18

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Legal Events

Date Code Title Description
ND Supplementary protection certificate (spc) granted
SPCG Supplementary protection certificate granted

Spc suppl protection certif: L53

Extension date: 20081210

FG Patent granted

Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD

MA Patent expired