DE602008005012D1 - Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate - Google Patents

Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate

Info

Publication number
DE602008005012D1
DE602008005012D1 DE602008005012T DE602008005012T DE602008005012D1 DE 602008005012 D1 DE602008005012 D1 DE 602008005012D1 DE 602008005012 T DE602008005012 T DE 602008005012T DE 602008005012 T DE602008005012 T DE 602008005012T DE 602008005012 D1 DE602008005012 D1 DE 602008005012D1
Authority
DE
Germany
Prior art keywords
hydroxy
isobutyl
preparation
rivate
isobutylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008005012T
Other languages
English (en)
Inventor
Hartmut Burghard Zinser
Peter Hermann Hoelzle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LITTLE ISLAND CO CORK
Original Assignee
LITTLE ISLAND CO CORK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LITTLE ISLAND CO CORK filed Critical LITTLE ISLAND CO CORK
Publication of DE602008005012D1 publication Critical patent/DE602008005012D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602008005012T 2007-04-27 2008-04-25 Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate Active DE602008005012D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07107177 2007-04-27
PCT/EP2008/055042 WO2008132154A1 (en) 2007-04-27 2008-04-25 Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives

Publications (1)

Publication Number Publication Date
DE602008005012D1 true DE602008005012D1 (de) 2011-03-31

Family

ID=38924830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008005012T Active DE602008005012D1 (de) 2007-04-27 2008-04-25 Herstellungsverfahren für n-isobutyl-n-(2-hydroxy-rivate

Country Status (20)

Country Link
US (1) US8076513B2 (de)
EP (1) EP2152667B1 (de)
JP (1) JP2010525029A (de)
CN (1) CN101668734A (de)
AT (1) ATE498606T1 (de)
AU (1) AU2008244306A1 (de)
BR (1) BRPI0810609A2 (de)
CA (1) CA2682616A1 (de)
CY (1) CY1111457T1 (de)
DE (1) DE602008005012D1 (de)
DK (1) DK2152667T3 (de)
ES (1) ES2360654T3 (de)
HR (1) HRP20110290T1 (de)
IL (1) IL200811A0 (de)
MX (1) MX2009011574A (de)
PL (1) PL2152667T3 (de)
PT (1) PT2152667E (de)
RU (1) RU2009143867A (de)
SI (1) SI2152667T1 (de)
WO (1) WO2008132154A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
WO2011092687A1 (en) 2010-01-28 2011-08-04 Mapi Pharma Hk Limited Process for the preparation of darunavir and darunavir intermediates
WO2011158259A1 (en) * 2010-06-18 2011-12-22 Matrix Laboratories Ltd Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof
WO2012070057A1 (en) 2010-11-23 2012-05-31 Matrix Laboratories Ltd Process for the preparation of (3r, 3as, 6ar)-hexahydrofuro [2, 3- b] furan-3-ol
CN105315178B (zh) * 2014-07-09 2018-07-06 浙江九洲药业股份有限公司 达芦那韦相关物质及其制备方法
CN114685322B (zh) * 2020-12-30 2023-08-25 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
JPH07110846B2 (ja) * 1987-12-23 1995-11-29 アグロカネショウ株式会社 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤
ATE172717T1 (de) * 1992-08-25 1998-11-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
EP0715618B1 (de) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US5929284A (en) 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
JP2000515488A (ja) 1995-11-15 2000-11-21 ジー．ディー．サール アンド カンパニー 置換スルホニルアルカノイルアミノヒドロキシエチルアミノスルホンアミド レトロウイルスプロテアーゼ阻害剤
PT1086076E (pt) 1998-06-19 2005-05-31 Vertex Pharma Inibidores de sulfonamida de aspartil protease
EP2336134B1 (de) 1998-06-23 2016-08-31 The United States of America, represented by the Secretary, Department of Health and Human Services Fitnesstest und Verfahren zur Verminderung von HIV-Resistenz gegen Therapie
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
WO2000010986A1 (fr) 1998-08-25 2000-03-02 Kaneka Corporation Procede de preparation de (2r, 3s)-3-amino-1,2-oxirane
EP1067125B1 (de) 1999-01-29 2006-07-26 Kaneka Corporation VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN
WO2000047551A2 (en) 1999-02-12 2000-08-17 Vertex Pharmaceuticals Incorporated Inhibitors of aspartyl protease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
KR100708221B1 (ko) 1999-08-31 2007-04-17 아지노모토 가부시키가이샤 에폭사이드 결정의 제조방법
EP2314562A3 (de) 1999-12-23 2012-03-21 Ampac Fine Chemicals LLC Verbesserte Herstellung von 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzensulfonylamid-Hydrochlorid und andere Derivate aus 2-Hydroxy-1,3-diaminen
KR20020046948A (ko) 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
JP2002332270A (ja) * 2001-03-07 2002-11-22 Ajinomoto Co Inc スルホンアミド誘導体の製造方法
EP1448567B1 (de) 2001-09-10 2009-12-30 Tibotec Pharmaceuticals VERFAHREN ZUR HERSTELLUNG VON HEXAHYDROFUROç2,3-B]FURAN-3-OL
US6919465B2 (en) 2002-10-09 2005-07-19 The Board Of Trustees Of The University Of Illinois Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds
EP1589018A4 (de) * 2002-12-27 2007-03-14 Sumitomo Chemical Co Herstellungsverfahren für hexahydrofurofuranol-derivate, zwischenprodukt davon und herstellungsverfahren dafür
UA79404C2 (en) * 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
SI1725566T1 (sl) 2003-12-23 2009-12-31 Tibotec Pharm Ltd Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata
TWI383975B (zh) 2004-03-31 2013-02-01 Tibotec Pharm Ltd 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法

Also Published As

Publication number Publication date
CY1111457T1 (el) 2015-08-05
MX2009011574A (es) 2009-11-09
IL200811A0 (en) 2010-05-17
ES2360654T3 (es) 2011-06-08
EP2152667A1 (de) 2010-02-17
US20100121094A1 (en) 2010-05-13
EP2152667B1 (de) 2011-02-16
HRP20110290T1 (hr) 2011-05-31
RU2009143867A (ru) 2011-06-10
DK2152667T3 (da) 2011-05-16
US8076513B2 (en) 2011-12-13
PT2152667E (pt) 2011-04-06
JP2010525029A (ja) 2010-07-22
WO2008132154A1 (en) 2008-11-06
SI2152667T1 (sl) 2011-06-30
ATE498606T1 (de) 2011-03-15
BRPI0810609A2 (pt) 2014-10-21
CN101668734A (zh) 2010-03-10
PL2152667T3 (pl) 2011-06-30
AU2008244306A1 (en) 2008-11-06
CA2682616A1 (en) 2008-11-06

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