HRP20110290T1 - Postupci za dobivanje derivata n-izobutil-n-(2-hidroksi-3-amino-4-fenilbutil)-p-nitrobenzensulfonilamida - Google Patents
Postupci za dobivanje derivata n-izobutil-n-(2-hidroksi-3-amino-4-fenilbutil)-p-nitrobenzensulfonilamida Download PDFInfo
- Publication number
- HRP20110290T1 HRP20110290T1 HR20110290T HRP20110290T HRP20110290T1 HR P20110290 T1 HRP20110290 T1 HR P20110290T1 HR 20110290 T HR20110290 T HR 20110290T HR P20110290 T HRP20110290 T HR P20110290T HR P20110290 T1 HRP20110290 T1 HR P20110290T1
- Authority
- HR
- Croatia
- Prior art keywords
- hydroxy
- phenylbutyl
- isobutyl
- amino
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 12
- 150000003333 secondary alcohols Chemical class 0.000 claims 4
- 150000003509 tertiary alcohols Chemical class 0.000 claims 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000002516 radical scavenger Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- RXZQKCYDYRLICS-UHFFFAOYSA-N [3-hydroxy-4-(2-methylpropylamino)-1-phenylbutan-2-yl]carbamic acid Chemical class CC(C)CNCC(O)C(NC(O)=O)CC1=CC=CC=C1 RXZQKCYDYRLICS-UHFFFAOYSA-N 0.000 abstract 1
- -1 p-nitrophenylsulfonyl halide Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07107177 | 2007-04-27 | ||
| PCT/EP2008/055042 WO2008132154A1 (en) | 2007-04-27 | 2008-04-25 | Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110290T1 true HRP20110290T1 (hr) | 2011-05-31 |
Family
ID=38924830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110290T HRP20110290T1 (hr) | 2007-04-27 | 2011-04-19 | Postupci za dobivanje derivata n-izobutil-n-(2-hidroksi-3-amino-4-fenilbutil)-p-nitrobenzensulfonilamida |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8076513B2 (de) |
| EP (1) | EP2152667B1 (de) |
| JP (1) | JP2010525029A (de) |
| CN (1) | CN101668734A (de) |
| AT (1) | ATE498606T1 (de) |
| AU (1) | AU2008244306A1 (de) |
| BR (1) | BRPI0810609A2 (de) |
| CA (1) | CA2682616A1 (de) |
| CY (1) | CY1111457T1 (de) |
| DE (1) | DE602008005012D1 (de) |
| DK (1) | DK2152667T3 (de) |
| ES (1) | ES2360654T3 (de) |
| HR (1) | HRP20110290T1 (de) |
| IL (1) | IL200811A0 (de) |
| MX (1) | MX2009011574A (de) |
| PL (1) | PL2152667T3 (de) |
| PT (1) | PT2152667E (de) |
| RU (1) | RU2009143867A (de) |
| SI (1) | SI2152667T1 (de) |
| WO (1) | WO2008132154A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| ES2516916T3 (es) | 2010-01-28 | 2014-10-31 | Mapi Pharma Limited | Procedimiento para la preparación de darunavir e intermedios de darunavir |
| WO2011158259A1 (en) * | 2010-06-18 | 2011-12-22 | Matrix Laboratories Ltd | Novel process for the preparation of (3s)-tetrahydrofuran-3-yl (is, 2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate and its pharmaceutically acceptable salts thereof |
| PT2643326T (pt) | 2010-11-23 | 2016-12-23 | Mylan Laboratories Ltd | Processo para a preparação de (3r,3as,6ar)-hexa-hidrofuro[2,3-b]furan-3-ol |
| CN105315178B (zh) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | 达芦那韦相关物质及其制备方法 |
| CN117142989A (zh) * | 2020-12-30 | 2023-12-01 | 上海飞腾医药科技有限公司 | 一种抗hiv类药物中间体晶体a的生长方法和所得晶体 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| JPH07110846B2 (ja) * | 1987-12-23 | 1995-11-29 | アグロカネショウ株式会社 | 置換ベンジルスルホアミド誘導体、その製法及び選択性除草剤 |
| KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| DE69415326T2 (de) | 1993-08-24 | 1999-06-02 | Searle & Co | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
| KR100411856B1 (ko) | 1995-02-03 | 2004-05-20 | 카네카 코포레이션 | α-할로케톤,α-할로히드린및에폭사이드의제조법 |
| EP0861249A1 (de) | 1995-11-15 | 1998-09-02 | G.D. Searle & Co. | Substituierte sulfonylalkanoylamino-hydroxyethylamino-sulfonamide als hemmer von retroviraler protease |
| AP1717A (en) | 1998-06-19 | 2007-01-30 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
| EP2336134B1 (de) | 1998-06-23 | 2016-08-31 | The United States of America, represented by the Secretary, Department of Health and Human Services | Fitnesstest und Verfahren zur Verminderung von HIV-Resistenz gegen Therapie |
| AU4828199A (en) | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
| DE69918050T2 (de) | 1998-08-25 | 2005-06-30 | Kaneka Corp. | Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran |
| US6344572B1 (en) | 1999-01-29 | 2002-02-05 | Kaneka Corporation | Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives |
| PT1159278E (pt) | 1999-02-12 | 2006-06-30 | Vertex Pharma | Inibidores de aspartil-protease |
| AR031520A1 (es) | 1999-06-11 | 2003-09-24 | Vertex Pharma | Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion |
| KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
| DE60039533D1 (de) * | 1999-12-23 | 2008-08-28 | Ampac Fine Chemicals Llc | Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
| KR20020046948A (ko) | 2000-12-12 | 2002-06-21 | 에가시라 구니오 | 에폭사이드 결정의 제조방법 |
| JP2002332270A (ja) * | 2001-03-07 | 2002-11-22 | Ajinomoto Co Inc | スルホンアミド誘導体の製造方法 |
| US7126015B2 (en) | 2001-09-10 | 2006-10-24 | Tibotec Pharmaceuticals Ltd. | Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol |
| WO2004033462A2 (en) | 2002-10-09 | 2004-04-22 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO [2, 3-b] FURAN AND RELATED COMPOUNDS |
| WO2004060895A1 (ja) | 2002-12-27 | 2004-07-22 | Sumitomo Chemical Company, Limited | ヘキサヒドロフロフラノール誘導体の製造方法、その中間体及びその製造方法 |
| UA79404C2 (en) * | 2003-10-02 | 2007-06-11 | Basf Ag | 2-cyanobenzenesulfonamide for controlling pests |
| ATE433982T1 (de) | 2003-12-23 | 2009-07-15 | Tibotec Pharm Ltd | Verfahren zur herstellung von (1s,2r)-3-ää(4- aminophenyl)sulfonylü(isobutyl)aminoü-1-benzyl- - hydroxypropylcarbamidsäure-(3r,3as,6ar)- hexahydrofuroä2,3-büfuran-3-ylester |
| TWI383975B (zh) | 2004-03-31 | 2013-02-01 | Tibotec Pharm Ltd | 製備（３Ｒ，３ａＳ，６ａＲ）六氫-呋喃并〔２，３-ｂ〕呋喃-３-醇之方法 |
-
2008
- 2008-04-25 BR BRPI0810609-6A2A patent/BRPI0810609A2/pt not_active IP Right Cessation
- 2008-04-25 CA CA002682616A patent/CA2682616A1/en not_active Abandoned
- 2008-04-25 WO PCT/EP2008/055042 patent/WO2008132154A1/en active Application Filing
- 2008-04-25 RU RU2009143867/04A patent/RU2009143867A/ru not_active Application Discontinuation
- 2008-04-25 US US12/597,088 patent/US8076513B2/en not_active Expired - Fee Related
- 2008-04-25 PT PT08749718T patent/PT2152667E/pt unknown
- 2008-04-25 MX MX2009011574A patent/MX2009011574A/es active IP Right Grant
- 2008-04-25 EP EP08749718A patent/EP2152667B1/de not_active Not-in-force
- 2008-04-25 CN CN200880013559A patent/CN101668734A/zh active Pending
- 2008-04-25 AU AU2008244306A patent/AU2008244306A1/en not_active Abandoned
- 2008-04-25 AT AT08749718T patent/ATE498606T1/de active
- 2008-04-25 JP JP2010504703A patent/JP2010525029A/ja active Pending
- 2008-04-25 DK DK08749718.6T patent/DK2152667T3/da active
- 2008-04-25 ES ES08749718T patent/ES2360654T3/es active Active
- 2008-04-25 PL PL08749718T patent/PL2152667T3/pl unknown
- 2008-04-25 SI SI200830232T patent/SI2152667T1/sl unknown
- 2008-04-25 DE DE602008005012T patent/DE602008005012D1/de active Active
-
2009
- 2009-09-08 IL IL200811A patent/IL200811A0/en unknown
-
2011
- 2011-04-19 HR HR20110290T patent/HRP20110290T1/hr unknown
- 2011-05-16 CY CY20111100463T patent/CY1111457T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008132154A1 (en) | 2008-11-06 |
| JP2010525029A (ja) | 2010-07-22 |
| PL2152667T3 (pl) | 2011-06-30 |
| SI2152667T1 (sl) | 2011-06-30 |
| DK2152667T3 (da) | 2011-05-16 |
| ATE498606T1 (de) | 2011-03-15 |
| CN101668734A (zh) | 2010-03-10 |
| EP2152667A1 (de) | 2010-02-17 |
| BRPI0810609A2 (pt) | 2014-10-21 |
| US20100121094A1 (en) | 2010-05-13 |
| DE602008005012D1 (de) | 2011-03-31 |
| CA2682616A1 (en) | 2008-11-06 |
| MX2009011574A (es) | 2009-11-09 |
| US8076513B2 (en) | 2011-12-13 |
| PT2152667E (pt) | 2011-04-06 |
| IL200811A0 (en) | 2010-05-17 |
| RU2009143867A (ru) | 2011-06-10 |
| ES2360654T3 (es) | 2011-06-08 |
| CY1111457T1 (el) | 2015-08-05 |
| AU2008244306A1 (en) | 2008-11-06 |
| EP2152667B1 (de) | 2011-02-16 |
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