SI1725566T1 - Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata - Google Patents

Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata

Info

Publication number
SI1725566T1
SI1725566T1 SI200431224T SI200431224T SI1725566T1 SI 1725566 T1 SI1725566 T1 SI 1725566T1 SI 200431224 T SI200431224 T SI 200431224T SI 200431224 T SI200431224 T SI 200431224T SI 1725566 T1 SI1725566 T1 SI 1725566T1
Authority
SI
Slovenia
Prior art keywords
amino
isobutyl
hydroxypropylcarbamate
hexahydrofuro
aminophenyl
Prior art date
Application number
SI200431224T
Other languages
English (en)
Inventor
Nicolaas Martha Felix Goyvaerts
Piet Tom Bert Paul Wigerinck
Hartmut Burghard Zinser
Birgit M Ebert
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34740665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1725566(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of SI1725566T1 publication Critical patent/SI1725566T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI200431224T 2003-12-23 2004-12-23 Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata SI1725566T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03104949 2003-12-23
US56818304P 2004-05-04 2004-05-04
EP04805020A EP1725566B1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
PCT/EP2004/053692 WO2005063770A1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Publications (1)

Publication Number Publication Date
SI1725566T1 true SI1725566T1 (sl) 2009-12-31

Family

ID=34740665

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431224T SI1725566T1 (sl) 2003-12-23 2004-12-23 Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata

Country Status (21)

Country Link
EP (1) EP1725566B1 (sl)
KR (1) KR101192859B1 (sl)
CN (1) CN1898248B (sl)
AT (1) ATE433982T1 (sl)
AU (1) AU2004309122B2 (sl)
BR (1) BRPI0417272B8 (sl)
CA (1) CA2549460C (sl)
CY (1) CY1109379T1 (sl)
DE (1) DE602004021640D1 (sl)
DK (1) DK1725566T3 (sl)
ES (1) ES2328701T3 (sl)
HR (1) HRP20090488T1 (sl)
IL (1) IL174960A (sl)
MX (1) MXPA06007211A (sl)
NO (1) NO337636B1 (sl)
PL (1) PL1725566T3 (sl)
PT (1) PT1725566E (sl)
RU (1) RU2376308C2 (sl)
SI (1) SI1725566T1 (sl)
WO (1) WO2005063770A1 (sl)
ZA (1) ZA200605163B (sl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI432438B (zh) 2005-11-28 2014-04-01 Tibotec Pharm Ltd 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物及衍生物
SI2089371T1 (sl) 2006-11-09 2011-05-31 Tibotec Pharm Ltd Postopki za pripravo heksahidrofuro(2,3-b)furan-3-ola
DK2152667T3 (da) * 2007-04-27 2011-05-16 Tibotec Pharm Ltd Fremgangsmåder til fremstilling af N-isobutyl-n-(2-hydroxy-3-amin-4-phenylbutyl)-p-nitrobenzenesulfonylamid-derivater
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
US20090131363A1 (en) * 2007-10-26 2009-05-21 Harbeson Scott L Deuterated darunavir
AR073248A1 (es) * 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2426124T3 (pl) * 2009-05-13 2013-12-31 Meiji Seika Pharma Co Ltd Sposób wytwarzania pirypiropenowych pochodnych
CA2776807C (en) 2009-09-17 2018-10-16 Mylan Laboratories Limited An improved process for the preparation of darunavir
AU2010340799B2 (en) 2010-01-05 2015-06-11 Cipla Limited Darunavir polymorph and process for preparation thereof
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
CN102584844B (zh) * 2011-01-11 2016-04-13 浙江九洲药业股份有限公司 一种达芦那韦晶型及其制备方法
WO2014016660A2 (en) 2012-07-24 2014-01-30 Laurus Labs Private Limited A process for preparation of darunavir
CN103893178B (zh) * 2014-03-19 2016-06-01 中山大学 苯-磺酰胺类化合物在制备抗hiv-1病毒药物中的应用
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
US10407438B2 (en) 2016-10-27 2019-09-10 Gilead Sciences, Inc. Crystalline forms of darunavir
AU2017361799B2 (en) 2016-11-17 2021-05-20 Janssen Sciences Ireland Unlimited Company A simplified procedure for the preparation of darunavir
CN117142989A (zh) * 2020-12-30 2023-12-01 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体a的生长方法和所得晶体
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0804428B1 (en) 1995-01-20 2007-12-26 G.D. Searle LLC. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
CA2186483A1 (en) 1995-02-03 1996-08-08 Akira Nishiyama Processes for producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
DK0815124T3 (da) 1995-03-10 2003-03-17 Searle & Co Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6344572B1 (en) 1999-01-29 2002-02-05 Kaneka Corporation Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
AU2002310818B2 (en) 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
AU2002362189A1 (en) * 2001-12-28 2003-07-24 Ajinomoto Co., Inc. Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same

Also Published As

Publication number Publication date
KR101192859B1 (ko) 2012-10-19
NO20063401L (no) 2006-07-21
DK1725566T3 (da) 2009-10-05
PT1725566E (pt) 2009-09-16
CY1109379T1 (el) 2014-07-02
IL174960A (en) 2011-06-30
ATE433982T1 (de) 2009-07-15
RU2376308C2 (ru) 2009-12-20
PL1725566T3 (pl) 2009-11-30
EP1725566B1 (en) 2009-06-17
RU2006126670A (ru) 2008-01-27
BRPI0417272B1 (pt) 2020-08-18
BRPI0417272B8 (pt) 2021-05-25
DE602004021640D1 (de) 2009-07-30
CA2549460C (en) 2014-08-05
BRPI0417272A (pt) 2007-03-27
AU2004309122B2 (en) 2011-07-21
IL174960A0 (en) 2006-08-20
ES2328701T3 (es) 2009-11-17
CA2549460A1 (en) 2005-07-14
EP1725566A1 (en) 2006-11-29
AU2004309122A1 (en) 2005-07-14
MXPA06007211A (es) 2006-08-18
NO337636B1 (no) 2016-05-23
CN1898248B (zh) 2011-08-17
WO2005063770A1 (en) 2005-07-14
HRP20090488T1 (en) 2009-10-31
CN1898248A (zh) 2007-01-17
KR20060123740A (ko) 2006-12-04
ZA200605163B (en) 2007-12-27

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