AR073248A1 - Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. - Google Patents
Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.Info
- Publication number
- AR073248A1 AR073248A1 ARP090103343A ARP090103343A AR073248A1 AR 073248 A1 AR073248 A1 AR 073248A1 AR P090103343 A ARP090103343 A AR P090103343A AR P090103343 A ARP090103343 A AR P090103343A AR 073248 A1 AR073248 A1 AR 073248A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- darunavir
- furan
- amino
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Reivindicacion 1: Un proceso para la preparacion de darunavir de formula (1) o un solvato, sal de adicion o forma polimorfica o pseudopolimorfica del mismo que comprende (i) hacer reaccionar un compuesto de formula (2) en donde PG representa un grupo protector de amino, con N-bencil-isobutilamina, es decir un compuesto de formula (3) para obtener un compuesto de formula (4); (ii) tratar el compuesto de formula (4) para eliminar el grupo protector PG para obtener un compuesto de formula (5); (iii) acoplar el compuesto de formula (5) con un derivado de (3R,3aS,6aR)-hexahidrofuro[2,3-b]furan-3-ilo para obtener un compuesto de formula (6); (iv) eliminar el grupo N-bencilo del compuesto de formula (6) para obtener un compuesto de formula (7); (v) introducir un grupo p-nitrofenilsulfonilo en el compuesto de formula (7) para obtener un compuesto de formula (8); (vi) reducir el grupo nitro del compuesto de formula (8) para formar darunavir o un solvato, sal de adicion o forma polimorfica o pseudopolimorfica del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08163383 | 2008-09-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073248A1 true AR073248A1 (es) | 2010-10-20 |
Family
ID=40786641
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103343A AR073248A1 (es) | 2008-09-01 | 2009-08-31 | Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso. |
ARP200100624A AR119702A2 (es) | 2008-09-01 | 2020-03-06 | Proceso para la preparación de (1s,2r)-3-[[(4-aminofenil)sulfonil](isobutil)amino]-1-bencil-2-hidroxipropilcarbamato de (3r,3as,6ar)-hexahidrofuro[2,3-b]furan-3-ilo |
ARP200100623A AR118270A2 (es) | 2008-09-01 | 2020-03-06 | PROCESO PARA LA PREPARACIÓN DEL SOLVATO ETANOLATO DE (1S,2R)-3-[[(4-AMINOFENIL)SULFONIL](ISOBUTIL)AMINO]-1-BENCIL-2-HIDROXIPROPILCARBAMATO DE (3R,3aS,6aR)-HEXAHIDROFURO[2,3-B]FURAN-3-ILO |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200100624A AR119702A2 (es) | 2008-09-01 | 2020-03-06 | Proceso para la preparación de (1s,2r)-3-[[(4-aminofenil)sulfonil](isobutil)amino]-1-bencil-2-hidroxipropilcarbamato de (3r,3as,6ar)-hexahidrofuro[2,3-b]furan-3-ilo |
ARP200100623A AR118270A2 (es) | 2008-09-01 | 2020-03-06 | PROCESO PARA LA PREPARACIÓN DEL SOLVATO ETANOLATO DE (1S,2R)-3-[[(4-AMINOFENIL)SULFONIL](ISOBUTIL)AMINO]-1-BENCIL-2-HIDROXIPROPILCARBAMATO DE (3R,3aS,6aR)-HEXAHIDROFURO[2,3-B]FURAN-3-ILO |
Country Status (12)
Country | Link |
---|---|
US (1) | US8580981B2 (es) |
EP (1) | EP2346877B1 (es) |
JP (1) | JP5498497B2 (es) |
CN (1) | CN102131815B (es) |
AR (3) | AR073248A1 (es) |
AU (1) | AU2009286619B2 (es) |
BR (1) | BRPI0917377B1 (es) |
CA (1) | CA2734814C (es) |
ES (1) | ES2519115T3 (es) |
MX (1) | MX2011002259A (es) |
TW (1) | TWI482775B (es) |
WO (1) | WO2010023322A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
BR112012009956A2 (pt) | 2009-10-30 | 2015-09-29 | Lupin Ltd | um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula. |
WO2011092687A1 (en) | 2010-01-28 | 2011-08-04 | Mapi Pharma Hk Limited | Process for the preparation of darunavir and darunavir intermediates |
CN102584844B (zh) * | 2011-01-11 | 2016-04-13 | 浙江九洲药业股份有限公司 | 一种达芦那韦晶型及其制备方法 |
CN102617586B (zh) * | 2011-01-26 | 2016-04-06 | 浙江九洲药业股份有限公司 | 地瑞那韦中间体的制备方法 |
WO2013011485A1 (en) | 2011-07-20 | 2013-01-24 | Ranbaxy Laboratories Limited | Process for the preparation of sulfonamides useful as retroviral protease inhibitors |
ES2969589T3 (es) | 2012-07-24 | 2024-05-21 | Laurus Labs Ltd | Solvato de Propionato de Darunavir |
CN105315178B (zh) * | 2014-07-09 | 2018-07-06 | 浙江九洲药业股份有限公司 | 达芦那韦相关物质及其制备方法 |
JP6435907B2 (ja) * | 2015-02-16 | 2018-12-12 | 住友化学株式会社 | ヘキサヒドロフロフラノール誘導体の製造方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ATE174587T1 (de) | 1993-08-24 | 1999-01-15 | Searle & Co | Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen |
CN1091088C (zh) | 1995-02-03 | 2002-09-18 | 钟渊化学工业株式会社 | α-卤代酮、α-卤代醇和环氧化物的制备方法 |
DE69711395T2 (de) | 1996-08-23 | 2002-11-07 | Gilead Sciences Inc | Verfahren zur herstellung von cyclohexen-carboxylatderivate |
GB9805898D0 (en) | 1998-03-20 | 1998-05-13 | Glaxo Group Ltd | Process for the sythesis of hiv protease inhibitors |
AU4828199A (en) | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
CA2336160C (en) | 1998-06-23 | 2015-02-17 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of compounds for treating hiv |
DE69918050T2 (de) | 1998-08-25 | 2005-06-30 | Kaneka Corp. | Verfahren zur herstellung von (2r,3s)-3-amino-1,2-oxiran |
WO2000044736A1 (fr) | 1999-01-29 | 2000-08-03 | Kaneka Corporation | PROCEDE DE PREPARATION DE DERIVES DE threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE |
KR100708221B1 (ko) | 1999-08-31 | 2007-04-17 | 아지노모토 가부시키가이샤 | 에폭사이드 결정의 제조방법 |
US6455738B1 (en) | 2000-07-13 | 2002-09-24 | Rhodia Chimie | Process for the sulfonation of an aromatic compound |
US6764545B2 (en) | 2000-12-12 | 2004-07-20 | Ajinomoto Co., Inc. | Production method of epoxide crystal |
JP4521185B2 (ja) | 2001-09-10 | 2010-08-11 | テイボテク・フアーマシユーチカルズ・リミテツド | ヘキサヒドロ−フロ[2,3−b]フラン−3−オールの製造法 |
CA2472133A1 (en) | 2001-12-28 | 2003-07-17 | Ajinomoto Co., Inc. | Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same |
AU2003271740B2 (en) | 2002-05-16 | 2010-05-13 | Janssen R&D Ireland | Pseudopolymorphic forms of a HIV protease inhibitor |
MXPA05001792A (es) | 2002-08-14 | 2005-04-25 | Tibotec Pharm Ltd | Oxindolsulfonamida sustituida como inhibidores de proteasa de virus de inmunodeficiencia humana de amplio espectro. |
CA2549460C (en) * | 2003-12-23 | 2014-08-05 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
RS51073B (sr) * | 2003-12-23 | 2010-10-31 | Tibotec Pharmaceuticals Ltd. | Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata |
CN1953964A (zh) | 2004-03-11 | 2007-04-25 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
CN1997363B (zh) | 2004-05-07 | 2012-03-28 | 塞阔伊亚药品公司 | 抗耐药性反转录病毒蛋白酶抑制剂 |
AR058238A1 (es) | 2005-11-28 | 2008-01-23 | Tibotec Pharm Ltd | Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih |
TWI385173B (zh) | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為hiv蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
-
2009
- 2009-08-31 AR ARP090103343A patent/AR073248A1/es active IP Right Grant
- 2009-08-31 TW TW098129186A patent/TWI482775B/zh not_active IP Right Cessation
- 2009-09-01 MX MX2011002259A patent/MX2011002259A/es active IP Right Grant
- 2009-09-01 EP EP09782438.7A patent/EP2346877B1/en active Active
- 2009-09-01 CN CN200980133649.8A patent/CN102131815B/zh active Active
- 2009-09-01 US US13/060,942 patent/US8580981B2/en active Active
- 2009-09-01 ES ES09782438.7T patent/ES2519115T3/es active Active
- 2009-09-01 WO PCT/EP2009/061253 patent/WO2010023322A1/en active Application Filing
- 2009-09-01 JP JP2011524412A patent/JP5498497B2/ja active Active
- 2009-09-01 BR BRPI0917377-3A patent/BRPI0917377B1/pt active IP Right Grant
- 2009-09-01 AU AU2009286619A patent/AU2009286619B2/en active Active
- 2009-09-01 CA CA2734814A patent/CA2734814C/en active Active
-
2020
- 2020-03-06 AR ARP200100624A patent/AR119702A2/es unknown
- 2020-03-06 AR ARP200100623A patent/AR118270A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2734814C (en) | 2017-03-07 |
AU2009286619B2 (en) | 2015-05-14 |
AU2009286619A1 (en) | 2010-03-04 |
TW201022276A (en) | 2010-06-16 |
BRPI0917377B1 (pt) | 2022-04-19 |
BRPI0917377A2 (pt) | 2015-12-01 |
EP2346877B1 (en) | 2014-08-20 |
MX2011002259A (es) | 2011-04-12 |
US20110160468A1 (en) | 2011-06-30 |
WO2010023322A1 (en) | 2010-03-04 |
EP2346877A1 (en) | 2011-07-27 |
TWI482775B (zh) | 2015-05-01 |
AR118270A2 (es) | 2021-09-22 |
CA2734814A1 (en) | 2010-03-04 |
US8580981B2 (en) | 2013-11-12 |
JP2012501316A (ja) | 2012-01-19 |
CN102131815B (zh) | 2014-10-15 |
AR119702A2 (es) | 2022-01-05 |
ES2519115T3 (es) | 2014-11-06 |
JP5498497B2 (ja) | 2014-05-21 |
CN102131815A (zh) | 2011-07-20 |
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