CU24177B1 - Derivados de heteroarilo como moduladores de nachr alfa 7 - Google Patents

Derivados de heteroarilo como moduladores de nachr alfa 7

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Publication number
CU24177B1
CU24177B1 CUP2013000116A CU20130116A CU24177B1 CU 24177 B1 CU24177 B1 CU 24177B1 CU P2013000116 A CUP2013000116 A CU P2013000116A CU 20130116 A CU20130116 A CU 20130116A CU 24177 B1 CU24177 B1 CU 24177B1
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CU
Cuba
Prior art keywords
heteroarilo
nachr
alfa
modulators
derivatives
Prior art date
Application number
CUP2013000116A
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English (en)
Other versions
CU20130116A7 (es
Inventor
Neelima Sinha
Gourhari Jana
Sachchidanand Sachchidanand
Sanjay Pralhad Kurhade
Navnath Popat Karche
Anil Kashiram Hajare
Ajay Ramchandra Tilekar
Rajender Kumar Kamboj
Venkata P Palle
Original Assignee
Lupin Ltd
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45873193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24177(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of CU20130116A7 publication Critical patent/CU20130116A7/es
Publication of CU24177B1 publication Critical patent/CU24177B1/es

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

Se divulga un compuesto de la fórmula (I), en donde Z, m y R1 -R6 se describen en la misma, como un modulador de receptores de acetilcolina nicotínica particularmente del subtipo alfa 7, en un sujeto en necesidad del mismo, para su uso ya sea solos o en combinaciones con otros medicamentos adecuados, y composiciones farmacéuticas que contienen dichos compuestos. También se divulgan un proceso de preparación de los compuestos y sus usos pretendidos en terapia, particularmente en la profilaxis y terapia de trastornos tales como la enfermedad de Alzheimer, deterioro cognitivo leve, demencia senil, y similares.
CUP2013000116A 2011-02-23 2012-02-22 Derivados de heteroarilo como moduladores de nachr alfa 7 CU24177B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN242KO2011 2011-02-23
IN1184KO2011 2011-09-09
PCT/IB2012/050806 WO2012114285A1 (en) 2011-02-23 2012-02-22 Heteroaryl derivatives as alpha7 nachr modulators

Publications (2)

Publication Number Publication Date
CU20130116A7 CU20130116A7 (es) 2014-03-26
CU24177B1 true CU24177B1 (es) 2016-04-25

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EP2678327B9 (en) 2016-12-28
DK2678327T3 (en) 2016-12-12
IL228052A0 (en) 2013-09-30
ZA201306223B (en) 2014-10-29
MX2013009709A (es) 2014-05-13
WO2012114285A1 (en) 2012-08-30
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HRP20161481T1 (hr) 2016-12-30
SI2678327T1 (sl) 2017-01-31
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AP2013007121A0 (en) 2013-09-30
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BR112013021602A2 (pt) 2019-09-24
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ECSP13012891A (es) 2013-10-31
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