EA201370184A1 - Гетероарильные производные - Google Patents

Гетероарильные производные

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Publication number
EA201370184A1
EA201370184A1 EA201370184A EA201370184A EA201370184A1 EA 201370184 A1 EA201370184 A1 EA 201370184A1 EA 201370184 A EA201370184 A EA 201370184A EA 201370184 A EA201370184 A EA 201370184A EA 201370184 A1 EA201370184 A1 EA 201370184A1
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EA
Eurasian Patent Office
Prior art keywords
compound
disclosed
analogs
heteroaryl derivatives
neniya
Prior art date
Application number
EA201370184A
Other languages
English (en)
Other versions
EA024170B1 (ru
Inventor
Неелима Синха
Гурхари Джана
Сачхчхидананд Сачхчхидананд
Санджай Пралхад Курхаде
Навнатх Попат Карчхе
Анил Каширам Хаджаре
Аджай Рамчхандра Тилекар
Венката П. Палле
Раджендер Кумар Камбодж
Original Assignee
Люпин Лимитед
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45873193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201370184(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Люпин Лимитед filed Critical Люпин Лимитед
Publication of EA201370184A1 publication Critical patent/EA201370184A1/ru
Publication of EA024170B1 publication Critical patent/EA024170B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Раскрыто соединение формулы Iгде Z, m и R-Rявляются такими, как описано в настоящем документе, используемое в качестве модулятора никотиновых ацетилхолиновых рецепторов, особенно подтипа α7, у субъекта, нуждающегося в этом, а также его аналоги, пролекарства, изотопно замещенные аналоги, метаболиты, фармацевтически приемлемые соли, полиморфы, сольваты, изомеры, клатраты и совместные кристаллы для применения либо отдельно, либо в комбинации с подходящими другими лекарственными препаратами и фармацевтические композиции, содержащие такие соединения и аналоги. Также раскрыт способ получения соединений и их предполагаемые применения в терапии, особенно в профилактике и терапии расстройств, таких как болезнь Альцгеймера, умеренное когнитивное нарушение, сенильная деменция и т.п.
EA201370184A 2011-02-23 2012-02-22 ГЕТЕРОАРИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ nAChR АЛЬФА7 EA024170B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN242KO2011 2011-02-23
IN1184KO2011 2011-09-09
PCT/IB2012/050806 WO2012114285A1 (en) 2011-02-23 2012-02-22 Heteroaryl derivatives as alpha7 nachr modulators

Publications (2)

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EA201370184A1 true EA201370184A1 (ru) 2013-12-30
EA024170B1 EA024170B1 (ru) 2016-08-31

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