MX343788B - Derivados de heteroarilo como moduladores de nachr alfa 7. - Google Patents

Derivados de heteroarilo como moduladores de nachr alfa 7.

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Publication number
MX343788B
MX343788B MX2013009709A MX2013009709A MX343788B MX 343788 B MX343788 B MX 343788B MX 2013009709 A MX2013009709 A MX 2013009709A MX 2013009709 A MX2013009709 A MX 2013009709A MX 343788 B MX343788 B MX 343788B
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MX
Mexico
Prior art keywords
analogues
therapy
compounds
disclosed
heteroaryl derivatives
Prior art date
Application number
MX2013009709A
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English (en)
Other versions
MX2013009709A (es
Inventor
Neelima Sinha
Gourhari Jana
Navnath Popat Karche
Venkata P Palle
Rajender Kumar Kamboj
Sachchidanand Sachchidanand
Sanjay Pralhad Kurhade
Anil Kashiram Hajare
Ajay Ramchandra Tilekar
Original Assignee
Lupin Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45873193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX343788(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of MX2013009709A publication Critical patent/MX2013009709A/es
Publication of MX343788B publication Critical patent/MX343788B/es

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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
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    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

Se divulga un compuesto de la fórmula (I), en donde Z, m y R1-R6 se describen en la misma, como un modulador de receptores de acetilcolina nicotínica particularmente del subtipo a7, en un sujeto en necesidad del mismo, así como sus análogos, profármacos, análogos isotópicamente sustituidos, metabolitos, sales farmacéuticamente aceptables, polimorfos, solvatos, isómeros, clatratos y co-cristales, para su uso ya sea solos o en combinaciones con otros medicamentos adecuados, y composiciones farmacéuticas que contienen dichos compuestos y análogos. También se divulgan un proceso de preparación de los compuestos y sus usos pretendidos en terapia, particularmente en la profilaxis y terapia de trastornos tales como la enfermedad de Alzheimer, deterioro cognitivo leve, demencia senil, y similares.
MX2013009709A 2011-02-23 2012-02-22 Derivados de heteroarilo como moduladores de nachr alfa 7. MX343788B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN242KO2011 2011-02-23
IN1184KO2011 2011-09-09
PCT/IB2012/050806 WO2012114285A1 (en) 2011-02-23 2012-02-22 Heteroaryl derivatives as alpha7 nachr modulators

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MX2013009709A MX2013009709A (es) 2014-05-13
MX343788B true MX343788B (es) 2016-11-23

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US (2) US9072731B2 (es)
EP (1) EP2678327B9 (es)
JP (1) JP6118270B2 (es)
KR (1) KR20140026378A (es)
CN (1) CN103402994B (es)
AP (1) AP3649A (es)
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