PA8785401A1 - Derivados de bencimidazol - Google Patents

Derivados de bencimidazol

Info

Publication number
PA8785401A1
PA8785401A1 PA20088785401A PA8785401A PA8785401A1 PA 8785401 A1 PA8785401 A1 PA 8785401A1 PA 20088785401 A PA20088785401 A PA 20088785401A PA 8785401 A PA8785401 A PA 8785401A PA 8785401 A1 PA8785401 A1 PA 8785401A1
Authority
PA
Panama
Prior art keywords
bencimidazol
derivatives
compounds
present
treatment
Prior art date
Application number
PA20088785401A
Other languages
English (en)
Inventor
Alan Reiter Lawrence
John Munchhof Michael
Scott Jones Christopher
Li Qifang
La Greca Susan
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8785401A1 publication Critical patent/PA8785401A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA 1 O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO,EN LA QUE R1,R2,R3A,R3B,R4,R5,X,M y N SON COMO SE DEFINE EN EL PRESENTE DOCUMENTO. TALES DERIVADOS DE BENCIMIDAZOL NOVEDOSOS SON ÚTILES EN EL TRATAMIENTO DE CRECIMIENTO CELULAR ANORMAL,TAL COMO CÁNCER, EN MAMÍFEROS.LA PRESENTE INVENCIÓN TAMBIÉN SE REFIERE A UN PROCEDIMIENTO DE USO DE TALES COMPUESTOS EN EL TRATAMIENTO DE CRECIMIENTO CELULAR ANORMAL EN MAMÍFEROS,ESPECIALMENTE SERES HUMANOS,Y A COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN TALES COMPUESTOS.
PA20088785401A 2007-06-29 2008-06-19 Derivados de bencimidazol PA8785401A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94728707P 2007-06-29 2007-06-29
US4164508P 2008-04-02 2008-04-02

Publications (1)

Publication Number Publication Date
PA8785401A1 true PA8785401A1 (es) 2009-01-23

Family

ID=40161351

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088785401A PA8785401A1 (es) 2007-06-29 2008-06-19 Derivados de bencimidazol

Country Status (46)

Country Link
US (2) US8148401B2 (es)
EP (1) EP2170860B9 (es)
JP (2) JP4567099B2 (es)
KR (1) KR101143246B1 (es)
CN (1) CN101687841B (es)
AP (1) AP2377A (es)
AR (1) AR067346A1 (es)
AU (1) AU2008272641B2 (es)
BR (1) BRPI0813412B8 (es)
CA (1) CA2690953C (es)
CL (1) CL2008001922A1 (es)
CO (1) CO6160232A2 (es)
CR (1) CR11150A (es)
CU (1) CU23847B1 (es)
CY (2) CY1118650T1 (es)
DK (1) DK2170860T5 (es)
DO (1) DOP2009000278A (es)
EA (1) EA016888B1 (es)
EC (1) ECSP099803A (es)
ES (1) ES2609258T3 (es)
FR (1) FR20C1038I2 (es)
GE (1) GEP20125702B (es)
GT (1) GT200900328A (es)
HK (1) HK1139658A1 (es)
HN (1) HN2008000974A (es)
HR (1) HRP20161562T2 (es)
HU (2) HUE030052T4 (es)
IL (1) IL202420A (es)
LT (2) LT2170860T (es)
MA (1) MA31466B1 (es)
ME (1) ME00962B (es)
MY (1) MY148636A (es)
NI (1) NI200900219A (es)
NL (1) NL301057I2 (es)
NO (1) NO2020027I1 (es)
NZ (1) NZ581889A (es)
PA (1) PA8785401A1 (es)
PE (2) PE20121010A1 (es)
PL (1) PL2170860T3 (es)
PT (1) PT2170860T (es)
RS (1) RS55395B9 (es)
SI (1) SI2170860T1 (es)
TN (1) TN2009000544A1 (es)
TW (1) TWI371451B (es)
UY (1) UY31164A1 (es)
WO (1) WO2009004427A2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2170860T5 (en) * 2007-06-29 2017-03-20 Pfizer benzimidazole
WO2010028192A1 (en) 2008-09-03 2010-03-11 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
US8835648B2 (en) * 2009-06-11 2014-09-16 Siena Biotech S.P.A. Hedgehog pathway antagonists and therapeutic applications thereof
WO2011024872A1 (ja) 2009-08-26 2011-03-03 武田薬品工業株式会社 縮合複素環誘導体およびその用途
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
JP5802756B2 (ja) 2010-10-20 2015-11-04 ファイザー・インク スムーズンド受容体モジュレーターとしてのピリジン−２−誘導体
JP5452459B2 (ja) 2010-12-16 2014-03-26 株式会社Ｎｔｔドコモ ホーム基地局及びハンドオーバ方法
DK2680694T3 (en) 2011-02-28 2019-03-25 Biomarin Pharm Inc HISTONDEACETYLASE INHIBITORS
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
EP2684167B1 (en) 2011-03-08 2020-09-09 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
FR2980477B1 (fr) 2011-09-23 2013-10-18 Centre Nat Rech Scient Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications
CA2849820C (en) 2011-09-26 2019-08-27 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (lpa) receptor antagonist
IN2014DN11205A (es) 2012-06-20 2015-10-02 Eutropics Pharmaceuticals Inc
EP2922544B1 (en) 2012-11-21 2018-08-01 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
US10029988B2 (en) 2013-03-15 2018-07-24 Biomarin Pharmaceutical Inc. HDAC inhibitors
US10435364B2 (en) 2013-04-17 2019-10-08 Albert Ludwigs Universität Freiburg Compounds for use as bromodomain inhibitors
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
GB2519344A (en) * 2013-10-18 2015-04-22 Redx Pharma Ltd Compounds
WO2015066305A1 (en) 2013-10-30 2015-05-07 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
RU2717564C2 (ru) * 2015-04-24 2020-03-24 Пфайзер Инк. Кристаллические формы 1-((2r,4r)-2-(1h-бензо[d]имидазол-2-ил)-1-метилпиперидин 4-ил)-3-(4-цианофенил)мочевины малеата
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2020164722A (ja) * 2019-03-29 2020-10-08 デクセリアルズ株式会社 接着剤組成物
EP4097093B8 (en) 2020-01-28 2024-02-28 Assia Chemical Industries LTD Processes for the preparation of glasdegib and salt thereof and solid state forms of glasdegib maleate and process for preparation thereof
CN113248475B (zh) * 2020-02-11 2023-03-17 中国科学院上海药物研究所 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途
EP4126237B1 (en) 2020-03-26 2024-04-10 LEK Pharmaceuticals d.d. Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
KR20230031285A (ko) 2020-06-26 2023-03-07 라퀄리아 파마 인코포레이티드 레티노이드와 암 치료제의 병용 요법이 효과적인 암 환자를 선별하는 방법 및 레티노이드와 암 치료제의 병용 의약
WO2023002362A1 (en) 2021-07-22 2023-01-26 Pfizer Inc. Treatment of hematological malignancy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1638765A (zh) 2001-07-27 2005-07-13 柯里斯公司 Hedgehog信号转导途径介质、其相关组合物以及应用
IL162851A0 (en) * 2001-12-04 2005-11-20 Actelion Pharmaceuticals Ltd 4-(Piperidyl-and pyrrolidyl-alkyl-ureido)-quinolines as urotensin ii receptor antagonists
TW200304820A (en) 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
JP2006505570A (ja) 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用
WO2005042495A1 (en) 2003-10-21 2005-05-12 Imclone Systems Incorporated (benzimidazol-2-yl)-phenyl-phenyl-urea compounds and methods for inhibiting heparanase activity
CA2543918A1 (en) 2003-10-28 2005-05-12 Dean Wilson Benzimidazoles useful as modulators of ion channels
CA2587489C (en) * 2004-11-03 2013-12-31 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE102005012875B4 (de) 2005-03-19 2006-11-16 Sanofi-Aventis Deutschland Gmbh Verwendung von Amino substituierten 8-N-Benzimidazolen
WO2006124780A2 (en) * 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
WO2008064830A1 (en) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses
CA2672815A1 (en) 2006-12-15 2008-06-26 Pfizer Products Inc. Benzimidazole derivatives for use in treating abnormal cell growth
DK2170860T5 (en) * 2007-06-29 2017-03-20 Pfizer benzimidazole
EP2303275A4 (en) 2008-06-17 2012-05-09 Univ Duke STANDARD RECEPTOR MODULATORS
US8507491B2 (en) 2008-08-25 2013-08-13 Irm Llc Compounds and compositions as hedgehog pathway inhibitors

Also Published As

Publication number Publication date
CO6160232A2 (es) 2010-05-20
BRPI0813412A2 (pt) 2014-12-30
TW200911792A (en) 2009-03-16
UY31164A1 (es) 2009-01-30
LTC2170860I2 (lt) 2022-03-10
NL301057I2 (nl) 2020-09-10
AU2008272641A1 (en) 2009-01-08
DK2170860T5 (en) 2017-03-20
CA2690953C (en) 2012-10-02
HUS2000031I1 (hu) 2020-09-28
TN2009000544A1 (fr) 2011-03-31
MY148636A (en) 2013-05-15
CU20090225A7 (es) 2012-02-15
PE20121010A1 (es) 2012-08-06
RS55395B1 (sr) 2017-04-28
HN2008000974A (es) 2011-01-24
DK2170860T3 (en) 2017-01-09
HUE030052T4 (en) 2017-06-28
AR067346A1 (es) 2009-10-07
AP2009005089A0 (en) 2009-12-31
CU23847B1 (es) 2012-10-15
JP4567099B2 (ja) 2010-10-20
HRP20161562T1 (hr) 2016-12-30
US20120157495A1 (en) 2012-06-21
JP2010280693A (ja) 2010-12-16
TWI371451B (en) 2012-09-01
EA200971104A1 (ru) 2010-06-30
BRPI0813412B8 (pt) 2021-05-25
FR20C1038I2 (fr) 2021-08-13
MA31466B1 (fr) 2010-06-01
LTPA2020528I1 (lt) 2020-09-25
CL2008001922A1 (es) 2009-01-02
KR101143246B1 (ko) 2012-05-18
NL301057I1 (nl) 2020-07-22
EP2170860A2 (en) 2010-04-07
EP2170860B1 (en) 2016-11-02
DOP2009000278A (es) 2009-12-31
WO2009004427A2 (en) 2009-01-08
HUE030052T2 (hu) 2017-04-28
NI200900219A (es) 2010-03-11
PE20090772A1 (es) 2009-06-24
US8431597B2 (en) 2013-04-30
JP2010531869A (ja) 2010-09-30
EA016888B1 (ru) 2012-08-30
HRP20161562T2 (hr) 2017-04-21
ECSP099803A (es) 2010-01-29
PT2170860T (pt) 2017-01-04
HK1139658A1 (en) 2010-09-24
BRPI0813412B1 (pt) 2020-01-21
US20090005416A1 (en) 2009-01-01
AU2008272641B2 (en) 2013-08-29
FR20C1038I1 (es) 2020-10-02
NZ581889A (en) 2011-05-27
ME00962B (me) 2012-06-20
CR11150A (es) 2010-02-08
EP2170860B9 (en) 2017-02-22
CN101687841B (zh) 2013-07-10
PL2170860T3 (pl) 2017-05-31
CN101687841A (zh) 2010-03-31
CY2020028I1 (el) 2020-11-25
RS55395B9 (sr) 2020-01-31
IL202420A0 (en) 2010-06-30
KR20100028120A (ko) 2010-03-11
LT2170860T (lt) 2017-01-10
WO2009004427A3 (en) 2009-06-04
SI2170860T1 (sl) 2017-01-31
IL202420A (en) 2014-05-28
CY1118650T1 (el) 2017-07-12
AP2377A (en) 2012-03-07
CA2690953A1 (en) 2009-01-08
NO2020027I1 (no) 2020-08-11
US8148401B2 (en) 2012-04-03
CY2020028I2 (el) 2020-11-25
GEP20125702B (en) 2012-12-10
ES2609258T3 (es) 2017-04-19
GT200900328A (es) 2011-08-29

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