CU20090225A7 - 2-piperidinilo bencimidazoles útiles en el tratamiento del crecimiento celular anormal - Google Patents

2-piperidinilo bencimidazoles útiles en el tratamiento del crecimiento celular anormal

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Publication number
CU20090225A7
CU20090225A7 CU20090225A CU20090225A CU20090225A7 CU 20090225 A7 CU20090225 A7 CU 20090225A7 CU 20090225 A CU20090225 A CU 20090225A CU 20090225 A CU20090225 A CU 20090225A CU 20090225 A7 CU20090225 A7 CU 20090225A7
Authority
CU
Cuba
Prior art keywords
treatment
useful
bencimidazoles
piperidinyl
cellular growth
Prior art date
Application number
CU20090225A
Other languages
English (en)
Other versions
CU23847B1 (es
Inventor
Lawrence Alan Reiter
Qifang Li
GRECA Susan LA
Christopher Scott Jones
Michael John Munchhof
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20090225A7 publication Critical patent/CU20090225A7/es
Publication of CU23847B1 publication Critical patent/CU23847B1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención se refiere a un compuesto de fórmula I ESPACIO PARA LA FÓRMULA o una sal farmacéuticamente aceptable del mismo, en la que R1, R2, R3A, R3B, R4, R5, X, m y n son como se definen en el presente documento. Tales derivados de bencimidazol novedosos son útiles en el tratamiento de crecimiento celular anormal, tal como cáncer, en mamíferos. La presente invención también se refiere a un procedimiento de uso de tales compuestos en el tratamiento de crecimiento celular anormal en mamíferos, especialmente seres humanos y a composiciones farmacéuticas que contienen tales compuestos.
CU2009000225A 2007-06-29 2009-12-21 2-piperidinilo bencimidazoles útiles en el tratamiento del crecimiento celular anormal CU23847B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94728707P 2007-06-29 2007-06-29
US4164508P 2008-04-02 2008-04-02
PCT/IB2008/001575 WO2009004427A2 (en) 2007-06-29 2008-06-16 Benzimidazole derivatives

Publications (2)

Publication Number Publication Date
CU20090225A7 true CU20090225A7 (es) 2012-02-15
CU23847B1 CU23847B1 (es) 2012-10-15

Family

ID=40161351

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2009000225A CU23847B1 (es) 2007-06-29 2009-12-21 2-piperidinilo bencimidazoles útiles en el tratamiento del crecimiento celular anormal

Country Status (46)

Country Link
US (2) US8148401B2 (es)
EP (1) EP2170860B9 (es)
JP (2) JP4567099B2 (es)
KR (1) KR101143246B1 (es)
CN (1) CN101687841B (es)
AP (1) AP2377A (es)
AR (1) AR067346A1 (es)
AU (1) AU2008272641B2 (es)
BR (1) BRPI0813412B8 (es)
CA (1) CA2690953C (es)
CL (1) CL2008001922A1 (es)
CO (1) CO6160232A2 (es)
CR (1) CR11150A (es)
CU (1) CU23847B1 (es)
CY (2) CY1118650T1 (es)
DK (1) DK2170860T5 (es)
DO (1) DOP2009000278A (es)
EA (1) EA016888B1 (es)
EC (1) ECSP099803A (es)
ES (1) ES2609258T3 (es)
FR (1) FR20C1038I2 (es)
GE (1) GEP20125702B (es)
GT (1) GT200900328A (es)
HK (1) HK1139658A1 (es)
HN (1) HN2008000974A (es)
HR (1) HRP20161562T2 (es)
HU (2) HUE030052T4 (es)
IL (1) IL202420A (es)
LT (2) LT2170860T (es)
MA (1) MA31466B1 (es)
ME (1) ME00962B (es)
MY (1) MY148636A (es)
NI (1) NI200900219A (es)
NL (1) NL301057I2 (es)
NO (1) NO2020027I1 (es)
NZ (1) NZ581889A (es)
PA (1) PA8785401A1 (es)
PE (2) PE20090772A1 (es)
PL (1) PL2170860T3 (es)
PT (1) PT2170860T (es)
RS (1) RS55395B9 (es)
SI (1) SI2170860T1 (es)
TN (1) TN2009000544A1 (es)
TW (1) TWI371451B (es)
UY (1) UY31164A1 (es)
WO (1) WO2009004427A2 (es)

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DOP2009000278A (es) 2009-12-31
CU23847B1 (es) 2012-10-15
US8148401B2 (en) 2012-04-03
IL202420A (en) 2014-05-28
GT200900328A (es) 2011-08-29
NL301057I2 (nl) 2020-09-10
PL2170860T3 (pl) 2017-05-31
HN2008000974A (es) 2011-01-24
ME00962B (me) 2012-06-20
AP2377A (en) 2012-03-07
US20120157495A1 (en) 2012-06-21
AU2008272641A1 (en) 2009-01-08
CN101687841A (zh) 2010-03-31
ECSP099803A (es) 2010-01-29
TN2009000544A1 (fr) 2011-03-31
ES2609258T3 (es) 2017-04-19
CY1118650T1 (el) 2017-07-12
RS55395B9 (sr) 2020-01-31
EP2170860B9 (en) 2017-02-22
JP2010280693A (ja) 2010-12-16
KR101143246B1 (ko) 2012-05-18
NO2020027I1 (no) 2020-08-11
CO6160232A2 (es) 2010-05-20
EA016888B1 (ru) 2012-08-30
EP2170860A2 (en) 2010-04-07
DK2170860T3 (en) 2017-01-09
FR20C1038I2 (fr) 2021-08-13
PA8785401A1 (es) 2009-01-23
GEP20125702B (en) 2012-12-10
EA200971104A1 (ru) 2010-06-30
WO2009004427A2 (en) 2009-01-08
BRPI0813412A2 (pt) 2014-12-30
FR20C1038I1 (es) 2020-10-02
TWI371451B (en) 2012-09-01
CL2008001922A1 (es) 2009-01-02
HUS2000031I1 (hu) 2020-09-28
PT2170860T (pt) 2017-01-04
AR067346A1 (es) 2009-10-07
CR11150A (es) 2010-02-08
LTPA2020528I1 (lt) 2020-09-25
IL202420A0 (en) 2010-06-30
KR20100028120A (ko) 2010-03-11
JP2010531869A (ja) 2010-09-30
JP4567099B2 (ja) 2010-10-20
LT2170860T (lt) 2017-01-10
AP2009005089A0 (en) 2009-12-31
WO2009004427A3 (en) 2009-06-04
PE20121010A1 (es) 2012-08-06
HK1139658A1 (en) 2010-09-24
RS55395B1 (sr) 2017-04-28
UY31164A1 (es) 2009-01-30
AU2008272641B2 (en) 2013-08-29
SI2170860T1 (sl) 2017-01-31
CA2690953C (en) 2012-10-02
LTC2170860I2 (lt) 2022-03-10
HUE030052T4 (en) 2017-06-28
CN101687841B (zh) 2013-07-10
NI200900219A (es) 2010-03-11
PE20090772A1 (es) 2009-06-24
US8431597B2 (en) 2013-04-30
CA2690953A1 (en) 2009-01-08
DK2170860T5 (en) 2017-03-20
HUE030052T2 (hu) 2017-04-28
US20090005416A1 (en) 2009-01-01
HRP20161562T2 (hr) 2017-04-21
CY2020028I1 (el) 2020-11-25
MY148636A (en) 2013-05-15
TW200911792A (en) 2009-03-16
BRPI0813412B1 (pt) 2020-01-21
NL301057I1 (nl) 2020-07-22
HRP20161562T1 (hr) 2016-12-30
BRPI0813412B8 (pt) 2021-05-25
EP2170860B1 (en) 2016-11-02
NZ581889A (en) 2011-05-27
CY2020028I2 (el) 2020-11-25
MA31466B1 (fr) 2010-06-01

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