HUP0300873A2 - Szubsztituált oxo-butánok sztereoszelektív redukciója - Google Patents
Szubsztituált oxo-butánok sztereoszelektív redukciójaInfo
- Publication number
- HUP0300873A2 HUP0300873A2 HU0300873A HUP0300873A HUP0300873A2 HU P0300873 A2 HUP0300873 A2 HU P0300873A2 HU 0300873 A HU0300873 A HU 0300873A HU P0300873 A HUP0300873 A HU P0300873A HU P0300873 A2 HUP0300873 A2 HU P0300873A2
- Authority
- HU
- Hungary
- Prior art keywords
- butanes
- substituted
- halo
- protected
- amino
- Prior art date
Links
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical class CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 title 1
- 238000011916 stereoselective reduction Methods 0.000 title 1
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 241000186146 Brevibacterium Species 0.000 abstract 1
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- -1 amino-4-substituted-butanes Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000013844 butane Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical class CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
A találmány tárgya új eljárás igen nagy disztereomer tisztaságú(1S,2S)-1-halogén-2-hidroxi-3-(védett)amino-4-szubsztituált-butánokelőállítására a megfelelő 1-halogén-2-oxo-3-(védett)amino-4-szubsztituált-butánok Rhodococcus és Brevibacterium fajokalkalmazásával történő szelektív, jó kitermeléssel kivitelezhetőenzimatikus redukciójával. Az így előállított szubsztituált butánokszámos terápiásan hasznosítható hatóanyag, így az angiotenzinkonvertáló enzim, renin és HIV-proteázok inhibitoraiként alkalmazhatóvegyületek szintézisének fontos intermedierjei. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22569500P | 2000-08-16 | 2000-08-16 | |
| US27753101P | 2001-03-21 | 2001-03-21 | |
| PCT/US2001/023113 WO2002014528A1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0300873A2 true HUP0300873A2 (hu) | 2003-12-29 |
| HUP0300873A3 HUP0300873A3 (en) | 2006-02-28 |
| HU229338B1 HU229338B1 (en) | 2013-11-28 |
Family
ID=26919835
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300873A HU229338B1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20020042124A1 (hu) |
| EP (1) | EP1309714B1 (hu) |
| JP (1) | JP3843255B2 (hu) |
| KR (1) | KR20040031674A (hu) |
| CN (1) | CN100335643C (hu) |
| AT (1) | ATE431422T1 (hu) |
| AU (2) | AU8069801A (hu) |
| BR (1) | BR0113236B1 (hu) |
| CA (1) | CA2417086A1 (hu) |
| CZ (1) | CZ303884B6 (hu) |
| DE (1) | DE60138712D1 (hu) |
| ES (1) | ES2325309T3 (hu) |
| HU (1) | HU229338B1 (hu) |
| IL (1) | IL154376A0 (hu) |
| MX (1) | MXPA03001312A (hu) |
| PL (1) | PL366098A1 (hu) |
| TW (1) | TWI287579B (hu) |
| WO (1) | WO2002014528A1 (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003000290A (ja) * | 2001-06-25 | 2003-01-07 | Kanegafuchi Chem Ind Co Ltd | 光学活性（ｒ）−２−クロロ−１−（３′−クロロフェニル）エタノールの製造法 |
| US7741082B2 (en) | 2004-04-14 | 2010-06-22 | Bristol-Myers Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
| US7582468B2 (en) | 2005-05-25 | 2009-09-01 | Bristol-Myers Squibb Company | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
| ES2310143B1 (es) * | 2007-06-15 | 2010-02-08 | Universitat Jaume I | Inhibidores de cisteina proteasas. |
| PT2170292E (pt) * | 2007-06-22 | 2014-03-06 | Bristol Myers Squibb Holdings Ireland | Composições de comprimido contendo atazanavir |
| SI2178513T1 (sl) * | 2007-06-22 | 2011-05-31 | Bristol Myers Squibb Co | Tabletni sestavki vsebujoäśi atazanavir |
| EP2178512B1 (en) * | 2007-06-22 | 2011-03-09 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
| DE602008005316D1 (de) * | 2007-06-22 | 2011-04-14 | Bristol Myers Squibb Co | Tablettierte atazanavirhaltige zusammensetzungen |
| TWI601825B (zh) | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| EP3409765B1 (en) | 2009-06-22 | 2021-08-04 | Codexis, Inc. | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| CN113026036B (zh) * | 2021-03-11 | 2022-06-07 | 南京工业大学 | 一种利用连续流电化学氧化合成硫叶立德类化合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61108394A (ja) | 1984-10-30 | 1986-05-27 | Sumitomo Chem Co Ltd | 光学活性１−（４−フエノキシフエノキシ）プロパン−２−オ−ルの生物化学的製造方法 |
| JPH02295969A (ja) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | 光学活性なアミノアルコール誘導体の製造法 |
| JPH02295970A (ja) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | 光学活性なプロパン―２―オール誘導体の製造法 |
| CA2103932A1 (en) * | 1992-11-05 | 1994-05-06 | Ramesh N. Patel | Stereoselective reduction of ketones |
| JP3529904B2 (ja) * | 1995-06-19 | 2004-05-24 | 鐘淵化学工業株式会社 | 光学活性１−ハロ−３−アミノ−４−フェニル−２−ブタノール誘導体の製造法 |
| JP3814766B2 (ja) | 1996-02-28 | 2006-08-30 | 日本農薬株式会社 | 光学活性な２−ハロ−１−（置換フェニル）エタノールの製造法 |
| US5849911A (en) | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| JP3941184B2 (ja) | 1997-10-06 | 2007-07-04 | 三菱化学株式会社 | 光学活性１−アシロキシ−３−クロロ−２−プロパノール、及び光学活性３−クロロ−１，２−プロパンジオールの製造法 |
-
2001
- 2001-07-20 US US09/909,684 patent/US20020042124A1/en not_active Abandoned
- 2001-07-20 AT AT01959109T patent/ATE431422T1/de not_active IP Right Cessation
- 2001-07-20 WO PCT/US2001/023113 patent/WO2002014528A1/en active IP Right Grant
- 2001-07-20 AU AU8069801A patent/AU8069801A/xx active Pending
- 2001-07-20 IL IL15437601A patent/IL154376A0/xx unknown
- 2001-07-20 PL PL01366098A patent/PL366098A1/xx not_active Application Discontinuation
- 2001-07-20 CN CNB01814196XA patent/CN100335643C/zh not_active Expired - Lifetime
- 2001-07-20 CZ CZ20030758A patent/CZ303884B6/cs not_active IP Right Cessation
- 2001-07-20 MX MXPA03001312A patent/MXPA03001312A/es active IP Right Grant
- 2001-07-20 EP EP01959109A patent/EP1309714B1/en not_active Expired - Lifetime
- 2001-07-20 JP JP2002519654A patent/JP3843255B2/ja not_active Expired - Lifetime
- 2001-07-20 ES ES01959109T patent/ES2325309T3/es not_active Expired - Lifetime
- 2001-07-20 CA CA002417086A patent/CA2417086A1/en not_active Abandoned
- 2001-07-20 HU HU0300873A patent/HU229338B1/hu unknown
- 2001-07-20 BR BRPI0113236-9A patent/BR0113236B1/pt not_active IP Right Cessation
- 2001-07-20 AU AU2001280698A patent/AU2001280698B2/en not_active Expired
- 2001-07-20 KR KR10-2003-7002257A patent/KR20040031674A/ko not_active Application Discontinuation
- 2001-07-20 DE DE60138712T patent/DE60138712D1/de not_active Expired - Lifetime
- 2001-08-16 TW TW090120123A patent/TWI287579B/zh not_active IP Right Cessation
-
2003
- 2003-09-12 US US10/661,893 patent/US7083973B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7083973B2 (en) | 2006-08-01 |
| IL154376A0 (en) | 2003-09-17 |
| US20020042124A1 (en) | 2002-04-11 |
| TWI287579B (en) | 2007-10-01 |
| HUP0300873A3 (en) | 2006-02-28 |
| BR0113236B1 (pt) | 2014-04-22 |
| JP3843255B2 (ja) | 2006-11-08 |
| MXPA03001312A (es) | 2003-10-06 |
| CA2417086A1 (en) | 2002-02-21 |
| CN100335643C (zh) | 2007-09-05 |
| EP1309714B1 (en) | 2009-05-13 |
| CZ303884B6 (cs) | 2013-06-12 |
| DE60138712D1 (de) | 2009-06-25 |
| AU2001280698B2 (en) | 2005-08-25 |
| EP1309714A4 (en) | 2006-04-05 |
| AU8069801A (en) | 2002-02-25 |
| CN1492932A (zh) | 2004-04-28 |
| PL366098A1 (en) | 2005-01-24 |
| ES2325309T3 (es) | 2009-09-01 |
| US20040058431A1 (en) | 2004-03-25 |
| HU229338B1 (en) | 2013-11-28 |
| JP2004511225A (ja) | 2004-04-15 |
| EP1309714A1 (en) | 2003-05-14 |
| BR0113236A (pt) | 2005-12-13 |
| KR20040031674A (ko) | 2004-04-13 |
| CZ2003758A3 (cs) | 2003-11-12 |
| WO2002014528A1 (en) | 2002-02-21 |
| ATE431422T1 (de) | 2009-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0300873A2 (hu) | Szubsztituált oxo-butánok sztereoszelektív redukciója | |
| IL165434A0 (en) | Compounds having DPP-IV inhibitory activity | |
| SG166001A1 (en) | Methods of generating and screening for proteases with altered specificity | |
| ATE103632T1 (de) | Enzymatische waschmittelzusammensetzung und verfahren zum stabilisieren der enzyme. | |
| WO2003010187A1 (fr) | Procede de production de dipeptides, l-aminoacide amide hydrolase s'utilisant dans ce contexte et procede de production de l-aminoacide amide hydrolase | |
| IL166255A0 (en) | Modified pictet-spengler reaction and products prepared therefrom | |
| AU5432198A (en) | Fatty-acid amide hydrolase | |
| AU2002354696A1 (en) | Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme | |
| EP0975353A4 (en) | PEPTIDYL-2-AMINO-1HYDROXYALKANESULPHONIC ACIDS AS CYSTEIN PROTEASE INHIBITORS | |
| DE60042209D1 (de) | Enzymatische synthese von deoxyribonucleotiden | |
| AU5239700A (en) | Process for the synthesis of n-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenyl-sulfon l)-2-hydroxy-2-methyl-propionamide | |
| TW200634151A (en) | Transformant expressing nitrile hydratase | |
| Hermes et al. | Purification and characterization of an L-aminopeptidase from Pseudomonas putida ATCC 12633 | |
| ATE448318T1 (de) | Verfahren zur hydrolyse von stärke ohne ph- anpassung | |
| Stella et al. | Resolution of N-protected amino acid esters using whole cells of Candida parapsilosis ATCC 7330 | |
| WO2001096366A3 (de) | Dipeptidische hemmstoffe für den gerinnungsfaktor xa | |
| WO2004011637A3 (en) | Modified adamts4 molecules and method of use thereof | |
| MY132553A (en) | Methods of making hiv-protease inhibitors and intermediates for making hiv-protease inhibitors | |
| EP0896057A3 (en) | D-aminoacylase | |
| AU2003264688A1 (en) | Steel hollow-head screw | |
| AU2003247599A1 (en) | Methods of modulating cytokinin related processes in a plant using b3 domain proteins | |
| AU5684099A (en) | Process for preparing piperazic acid and its conversion to n-acylated bicyclic rings containing n,n-linkages useful as intermediates for caspase inhibitors | |
| HUP0401794A2 (hu) | Eljárás heparin előállítására, hízósejttenyészetekből kiindulva | |
| DE59812724D1 (de) | Serin-proteinase-inhibitoren | |
| SI1539815T1 (sl) | Kristalna struktura encima, ki pretvarja angiotenzin (ACE), in njegove uporabe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FH91 | Appointment of a representative |
Free format text: FORMER REPRESENTATIVE(S): BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVIVOEI IRODA, HU Representative=s name: RATONYI ZOLTAN, S.B.G. & K. SZABADALMI UEGYVIV, HU |
|
| FH92 | Termination of representative |
Representative=s name: BELICZAY LASZLO, S.B.G. & K. SZABADALMI UEGYVI, HU |
|
| GB9A | Succession in title |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH Free format text: FORMER OWNER(S): BRISTOL-MYERS SQUIBB CO., US |
|
| HC9A | Change of name, address |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH Free format text: FORMER OWNER(S): BRISTOL-MYERS SQUIBB CO., US; BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |
|
| HC9A | Change of name, address |
Owner name: BRISTOL-MYERS SQUIBB HOLDINGS IRELAND UNLIMITE, CH Free format text: FORMER OWNER(S): BRISTOL-MYERS SQUIBB CO., US; BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH; BRISTOL-MYERS SQUIBB HOLDINGS IRELAND, CH |