DE60042209D1 - Enzymatische synthese von deoxyribonucleotiden - Google Patents

Enzymatische synthese von deoxyribonucleotiden

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Publication number
DE60042209D1
DE60042209D1 DE60042209T DE60042209T DE60042209D1 DE 60042209 D1 DE60042209 D1 DE 60042209D1 DE 60042209 T DE60042209 T DE 60042209T DE 60042209 T DE60042209 T DE 60042209T DE 60042209 D1 DE60042209 D1 DE 60042209D1
Authority
DE
Germany
Prior art keywords
deoxyribonucleotides
enzymatic synthesis
synthesis
enzymatic
deoxyribonucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042209T
Other languages
English (en)
Inventor
Wilhelm Tischer
Hans-Georg Ihlenfeldt
Octavian Barzu
Hiroshi Sakamoto
Elisabeth Pistotnik
Philippe Marliere
Sylvie Pochet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238824&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60042209(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of DE60042209D1 publication Critical patent/DE60042209D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
DE60042209T 1999-08-20 2000-08-18 Enzymatische synthese von deoxyribonucleotiden Expired - Lifetime DE60042209D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99116425 1999-08-20
PCT/EP2000/008088 WO2001014566A2 (en) 1999-08-20 2000-08-18 Enzymatic synthesis of deoxyribonucleosides

Publications (1)

Publication Number Publication Date
DE60042209D1 true DE60042209D1 (de) 2009-06-25

Family

ID=8238824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042209T Expired - Lifetime DE60042209D1 (de) 1999-08-20 2000-08-18 Enzymatische synthese von deoxyribonucleotiden

Country Status (10)

Country Link
US (2) US7229797B1 (de)
EP (1) EP1206551B2 (de)
JP (1) JP2003507071A (de)
KR (1) KR20020048930A (de)
AT (1) ATE431416T1 (de)
AU (1) AU6571700A (de)
CA (1) CA2382462A1 (de)
DE (1) DE60042209D1 (de)
HU (1) HUP0203049A3 (de)
WO (1) WO2001014566A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001275285A1 (en) 2000-06-06 2001-12-17 Bristol-Myers Squibb Company B7-related nucleic acids and polypeptides and their uses for immunomodulation
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
US6858721B2 (en) 2001-05-01 2005-02-22 Mitsui Chemicals, Inc. Method for producing cytosine nucleoside compounds
FR2829774B1 (fr) * 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
US7381555B2 (en) 2001-09-14 2008-06-03 Institut Pasteur Lactobacillus N-deoxyribosyl transferases, corresponding nucleotide sequences and their uses
US20040214314A1 (en) 2001-11-02 2004-10-28 Friedrich Srienc High throughput bioreactor
KR100817462B1 (ko) * 2003-06-24 2008-03-31 에볼로직 소시에떼 아노님 2-데하이드로-3-데옥시-ｄ-글루코네이트로부터의2'-데옥시뉴클레오시드 및 2'-데옥시뉴클레오시드전구체들의 제조
EP1491549A1 (de) * 2003-06-24 2004-12-29 Evologic S.A. Herstellung von 2'-Deoxynukleoside und 2'-Deoxynukleosidvorläufern von 2-Dehydro-3-Deoxy-D-Gluconat
GB2403950A (en) * 2003-07-18 2005-01-19 Mitsui Chemicals Inc Pyrimidine nucleosides from reaction of sugar phosphate with pyrimidine base derivative & enzyme having cytosine nucleoside phosphorylase activity
WO2005045052A1 (ja) * 2003-11-11 2005-05-19 Mitsui Chemicals, Inc. ペントース−５−リン酸エステルの製造方法
FR2853906B1 (fr) * 2004-06-07 2006-04-14 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
LT2304054T (lt) * 2008-06-11 2017-10-10 Orion Pharma (Uk) Limited Izoterminė nukleorūgšties amplifkacija
WO2014072487A1 (en) * 2012-11-08 2014-05-15 Centre National De La Recherche Scientifique (Cnrs) New phosphodeoxyribosyltransferase mutant enzymes and uses thereof
JP2016518838A (ja) * 2013-04-29 2016-06-30 プラズミア バイオテック，エス．エル． 活性医薬成分としてのヌクレオシドアナログの生体触媒生成
JP2015160832A (ja) * 2014-02-27 2015-09-07 大陽日酸株式会社 ヌクレオシド化合物の製造方法
CN112601821A (zh) * 2018-07-09 2021-04-02 科德克希思公司 工程化磷酸戊糖变位酶变体酶
MX2021000278A (es) 2018-07-09 2021-03-31 Merck Sharp & Dohme Llc Sintesis enzimatica de analogos de nucleosido de 4'-etinilo.
US11162105B2 (en) 2018-07-09 2021-11-02 Codexis, Inc. Engineered purine nucleoside phosphorylase variant enzymes
CA3148183A1 (en) * 2019-08-28 2021-03-04 Gang Meng Escherichia coli-based recombinant strain, construction method therefor and use thereof
CN110592084B (zh) * 2019-08-28 2023-07-28 内蒙古伊品生物科技有限公司 一种rhtA基因启动子改造的重组菌株及其构建方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170909B (it) * 1980-04-23 1987-06-03 Wellcome Found Composizione per il trattamento di infiammazioni a base di analoghi della adenosina e procedimento di preparazione relativo
JPS5863393A (ja) * 1981-10-13 1983-04-15 Ajinomoto Co Inc リボノフラノシル又はデオキシリボフラノシルプリン誘導体の製造法
EP0090417B1 (de) * 1982-04-01 1989-03-01 Yamasa Shoyu Kabushiki Kaisha Verfahren zur Herstellung von 3'-Deoxyguanosin
JP2795748B2 (ja) * 1989-02-28 1998-09-10 ヤマサ醤油株式会社 ヌクレオシドの製造法
DK0593757T3 (da) * 1989-07-31 1997-07-07 Inst Of Protein Research Russi Fremgangsmåde til opnåelse af polypeptider i et cellefrit system
US5728554A (en) * 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages

Also Published As

Publication number Publication date
EP1206551A2 (de) 2002-05-22
ATE431416T1 (de) 2009-05-15
US20080280329A1 (en) 2008-11-13
HUP0203049A2 (hu) 2002-12-28
US7229797B1 (en) 2007-06-12
JP2003507071A (ja) 2003-02-25
CA2382462A1 (en) 2001-03-01
HUP0203049A3 (en) 2007-03-28
EP1206551B2 (de) 2011-10-26
EP1206551B1 (de) 2009-05-13
AU6571700A (en) 2001-03-19
WO2001014566A2 (en) 2001-03-01
KR20020048930A (ko) 2002-06-24
WO2001014566A3 (en) 2001-09-20

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