DK0815124T3 - Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser - Google Patents

Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser

Info

Publication number
DK0815124T3
DK0815124T3 DK96911230T DK96911230T DK0815124T3 DK 0815124 T3 DK0815124 T3 DK 0815124T3 DK 96911230 T DK96911230 T DK 96911230T DK 96911230 T DK96911230 T DK 96911230T DK 0815124 T3 DK0815124 T3 DK 0815124T3
Authority
DK
Denmark
Prior art keywords
retroviral
inhibitors
retroviral proteases
protease
heterocyclic carbonylamino
Prior art date
Application number
DK96911230T
Other languages
English (en)
Inventor
Michael L Vazquez
John N Freskos
Daniel P Getman
James A Sikorski
David L Brown
Srinivasan Nagarajan
Gary A Decrescenzo
Balekudru Devadas
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0815124T3 publication Critical patent/DK0815124T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK96911230T 1995-03-10 1996-03-07 Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser DK0815124T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
DK0815124T3 true DK0815124T3 (da) 2003-03-17

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96911230T DK0815124T3 (da) 1995-03-10 1996-03-07 Heterocyckliske carbonylaminosyre-hydroxyethylamino-sulfonamidinhibitorer af retrovirale proteaser

Country Status (20)

Country Link
US (3) US5972989A (da)
EP (1) EP0815124B1 (da)
JP (1) JP4124818B2 (da)
CN (2) CN1530372A (da)
AT (1) ATE229033T1 (da)
AU (1) AU717598B2 (da)
BR (1) BR9607625A (da)
CA (1) CA2215022A1 (da)
CZ (1) CZ297676B6 (da)
DE (1) DE69625183T2 (da)
DK (1) DK0815124T3 (da)
ES (1) ES2190793T3 (da)
HU (1) HUP9800518A3 (da)
MX (1) MX9706946A (da)
NO (1) NO974147L (da)
NZ (1) NZ306027A (da)
PL (1) PL184771B1 (da)
PT (1) PT815124E (da)
RU (1) RU2174519C2 (da)
WO (1) WO1996028465A1 (da)

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CN1530372A (zh) * 1995-03-10 2004-09-22 G.D.ɪ����˾ 杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
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JP4482783B2 (ja) 1999-01-28 2010-06-16 味の素株式会社 α−アミノケトン類の製造方法
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
CN101230067B (zh) 2001-02-14 2011-06-15 泰博特克药品有限公司 广谱的2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
SK288232B6 (sk) 2001-04-09 2014-11-04 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie
CA2444895C (en) 2001-05-11 2011-02-15 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
EP1463502B1 (en) 2001-12-21 2011-07-13 Tibotec Pharmaceuticals Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
BR0310089A (pt) * 2002-05-17 2005-02-15 Tibotec Pharm Ltd Inibidores de protease de hiv de sulfonamida benzisoxazol substituìda de largo espectro
EA010486B1 (ru) * 2002-08-14 2008-10-30 Тиботек Фармасьютикалз Лтд. Замещенные оксиндолсульфонамидные ингибиторы вич-протеазы широкого спектра действия
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
CA2537877C (en) * 2003-09-30 2015-03-17 Tibotec Pharmaceuticals Ltd. Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
ME01059B (me) 2003-12-23 2012-10-20 Janssen Sciences Ireland Uc Proces za pripremanje (3r,3as,6ar)-heksahidrofuro [2,3-b] furan-3-il (1s,2r)-3-[[(4-aminofenil) sulfonil] (izobutil) amino]-1-benzil-2- hidroksipropilkarbamata
SI1725566T1 (sl) 2003-12-23 2009-12-31 Tibotec Pharm Ltd Postopek za pripravo (3R,3aS,6aR)-heksahidrofuro(2,3-b)furan-3-il (1S,2R)-3-(((4-aminofenil)sulfonil)(izobutil)amino)-1-benzil-2- hidroksipropilkarbamata
US8106090B2 (en) 2005-07-20 2012-01-31 Eli Lilly And Company 1-amino linked compounds
WO2008022345A2 (en) 2006-08-18 2008-02-21 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450
CN101965186A (zh) 2007-11-28 2011-02-02 塞阔伊亚药品公司 抑制细胞色素p450 2d6的化合物和方法
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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CN1530372A (zh) * 1995-03-10 2004-09-22 G.D.ɪ����˾ 杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂

Also Published As

Publication number Publication date
AU5417896A (en) 1996-10-02
US6063795A (en) 2000-05-16
NO974147D0 (no) 1997-09-09
PL322179A1 (en) 1998-01-19
RU2174519C2 (ru) 2001-10-10
CN1530372A (zh) 2004-09-22
ATE229033T1 (de) 2002-12-15
CZ282397A3 (cs) 1998-02-18
JP4124818B2 (ja) 2008-07-23
HUP9800518A3 (en) 1998-09-28
US5972989A (en) 1999-10-26
PL184771B1 (pl) 2002-12-31
ES2190793T3 (es) 2003-08-16
BR9607625A (pt) 1999-06-15
EP0815124B1 (en) 2002-12-04
CN1149223C (zh) 2004-05-12
AU717598B2 (en) 2000-03-30
NO974147L (no) 1997-11-04
MX9706946A (es) 1997-11-29
DE69625183D1 (en) 2003-01-16
PT815124E (pt) 2003-04-30
EP0815124A1 (en) 1998-01-07
CZ297676B6 (cs) 2007-03-07
US6214861B1 (en) 2001-04-10
CA2215022A1 (en) 1996-09-19
WO1996028465A1 (en) 1996-09-19
CN1183102A (zh) 1998-05-27
DE69625183T2 (de) 2003-10-09
NZ306027A (en) 1999-03-29
JPH11501920A (ja) 1999-02-16
HUP9800518A2 (hu) 1998-06-29

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