PT815124E - Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo - Google Patents

Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo

Info

Publication number
PT815124E
PT815124E PT96911230T PT96911230T PT815124E PT 815124 E PT815124 E PT 815124E PT 96911230 T PT96911230 T PT 96911230T PT 96911230 T PT96911230 T PT 96911230T PT 815124 E PT815124 E PT 815124E
Authority
PT
Portugal
Prior art keywords
inhibitors
retroviral
aminoacides
heterocyclocarbonyl
hydroxyethylamino
Prior art date
Application number
PT96911230T
Other languages
English (en)
Inventor
Michael L Vasquez
Daniel P Getman
Gary A Decrescenzo
John N Freskos
James A Sikorski
Balekudru Devadas
David L Brown
Srinivasan Nagarajan
Joseph J Macdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT815124E publication Critical patent/PT815124E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
PT96911230T 1995-03-10 1996-03-07 Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo PT815124E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
PT815124E true PT815124E (pt) 2003-04-30

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96911230T PT815124E (pt) 1995-03-10 1996-03-07 Inibidores protease retroviral sulfonamida hidroxietilamino aminoacido heterociclocarbonilo

Country Status (20)

Country Link
US (3) US5972989A (pt)
EP (1) EP0815124B1 (pt)
JP (1) JP4124818B2 (pt)
CN (2) CN1530372A (pt)
AT (1) ATE229033T1 (pt)
AU (1) AU717598B2 (pt)
BR (1) BR9607625A (pt)
CA (1) CA2215022A1 (pt)
CZ (1) CZ297676B6 (pt)
DE (1) DE69625183T2 (pt)
DK (1) DK0815124T3 (pt)
ES (1) ES2190793T3 (pt)
HU (1) HUP9800518A3 (pt)
MX (1) MX9706946A (pt)
NO (1) NO974147L (pt)
NZ (1) NZ306027A (pt)
PL (1) PL184771B1 (pt)
PT (1) PT815124E (pt)
RU (1) RU2174519C2 (pt)
WO (1) WO1996028465A1 (pt)

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US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
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DK1370543T3 (da) 2001-02-14 2007-02-19 Tibotec Pharm Ltd Bredspektrede 2-(substitueret amino) benzothiazol- sulfonamid-HIV-proteaseinhibitorer
EE05384B1 (et) 2001-04-09 2011-02-15 Tibotec�Pharmaceuticals�Ltd. LaiaspektrilisedÁ2-(asendatudÁamino)bensoksasoolsulfoonamiididÁkuiÁHIVÁproteaasiÁinhibiitorid,ÁnendeÁkasutamine,ÁfarmatseutilineÁkompositsioonÁjaÁmeetodÁretroviiruseÁreplikatsiooniÁinhibeerimiseks
AU2002310818B2 (en) 2001-05-11 2007-12-13 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
KR100942743B1 (ko) 2001-12-21 2010-02-16 티보텍 파마슈티칼즈 리미티드 광범위 스펙트럼 헤테로사이클릭 치환된 페닐 포함설폰아미드 ｈｉｖ 프로테아제 저해제
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
MXPA04011466A (es) * 2002-05-17 2005-02-14 Tibotec Pharm Ltd Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro.
EP1546153A1 (en) * 2002-08-14 2005-06-29 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
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AP1985A (en) * 2003-09-30 2009-03-30 Tibotec Pharm Ltd Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
WO2005063770A1 (en) 2003-12-23 2005-07-14 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
EP1910317B1 (en) * 2005-07-20 2013-07-03 Eli Lilly And Company 1-amino linked compounds
AU2007285759B2 (en) 2006-08-18 2013-11-21 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450
CA2707161C (en) 2007-11-28 2016-08-16 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome p450 2d6
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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Also Published As

Publication number Publication date
DE69625183T2 (de) 2003-10-09
DE69625183D1 (en) 2003-01-16
CZ282397A3 (cs) 1998-02-18
EP0815124B1 (en) 2002-12-04
PL322179A1 (en) 1998-01-19
ATE229033T1 (de) 2002-12-15
CN1530372A (zh) 2004-09-22
CZ297676B6 (cs) 2007-03-07
HUP9800518A3 (en) 1998-09-28
CN1183102A (zh) 1998-05-27
EP0815124A1 (en) 1998-01-07
NO974147D0 (no) 1997-09-09
WO1996028465A1 (en) 1996-09-19
NZ306027A (en) 1999-03-29
RU2174519C2 (ru) 2001-10-10
US6063795A (en) 2000-05-16
PL184771B1 (pl) 2002-12-31
DK0815124T3 (da) 2003-03-17
JPH11501920A (ja) 1999-02-16
MX9706946A (es) 1997-11-29
US6214861B1 (en) 2001-04-10
AU717598B2 (en) 2000-03-30
BR9607625A (pt) 1999-06-15
NO974147L (no) 1997-11-04
CN1149223C (zh) 2004-05-12
JP4124818B2 (ja) 2008-07-23
HUP9800518A2 (hu) 1998-06-29
CA2215022A1 (en) 1996-09-19
ES2190793T3 (es) 2003-08-16
AU5417896A (en) 1996-10-02
US5972989A (en) 1999-10-26

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