BR9607625A - Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila - Google Patents

Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila

Info

Publication number
BR9607625A
BR9607625A BR9607625A BR9607625A BR9607625A BR 9607625 A BR9607625 A BR 9607625A BR 9607625 A BR9607625 A BR 9607625A BR 9607625 A BR9607625 A BR 9607625A BR 9607625 A BR9607625 A BR 9607625A
Authority
BR
Brazil
Prior art keywords
hydroxyethylamino
retroviral
amino acid
protease inhibitors
heterocyclocarbonyl
Prior art date
Application number
BR9607625A
Other languages
English (en)
Inventor
Daniel P Getman
Gary A Descrescenzo
John N Freskos
Michael L Vazquez
James A Sikorski
Balekudru Devadas
Srinivasan Nagarajan
David L Brown
Joseph J Mcdonald
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/474,117 external-priority patent/US5776971A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9607625A publication Critical patent/BR9607625A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR9607625A 1995-03-10 1996-03-07 Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila BR9607625A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40241995A 1995-03-10 1995-03-10
US08/474,117 US5776971A (en) 1995-03-10 1995-06-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002683 WO1996028465A1 (en) 1995-03-10 1996-03-07 Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (1)

Publication Number Publication Date
BR9607625A true BR9607625A (pt) 1999-06-15

Family

ID=27017874

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9607625A BR9607625A (pt) 1995-03-10 1996-03-07 Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila

Country Status (20)

Country Link
US (3) US5972989A (pt)
EP (1) EP0815124B1 (pt)
JP (1) JP4124818B2 (pt)
CN (2) CN1149223C (pt)
AT (1) ATE229033T1 (pt)
AU (1) AU717598B2 (pt)
BR (1) BR9607625A (pt)
CA (1) CA2215022A1 (pt)
CZ (1) CZ297676B6 (pt)
DE (1) DE69625183T2 (pt)
DK (1) DK0815124T3 (pt)
ES (1) ES2190793T3 (pt)
HU (1) HUP9800518A3 (pt)
MX (1) MX9706946A (pt)
NO (1) NO974147L (pt)
NZ (1) NZ306027A (pt)
PL (1) PL184771B1 (pt)
PT (1) PT815124E (pt)
RU (1) RU2174519C2 (pt)
WO (1) WO1996028465A1 (pt)

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US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
RU2174519C2 (ru) * 1995-03-10 2001-10-10 Джи. Ди. Сирл Энд Ко. Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу
US6407134B1 (en) * 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP0983228A4 (en) * 1997-05-08 2002-08-07 Smithkline Beecham Corp PROTEASE INHIBITORS
EP1095022A1 (en) 1998-07-08 2001-05-02 G.D. Searle & Co. Retroviral protease inhibitors
EP1148046B1 (en) * 1999-01-28 2008-10-22 Ajinomoto Co., Inc. Process for the preparation of alpha-aminoketones
AR031520A1 (es) * 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
BR0207862A (pt) 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
CZ303139B6 (cs) * 2001-04-09 2012-04-25 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)-benzoxazolsulfonamidový derivát, farmaceutická kompozice s jeho obsahem a zpusob in vitro inhibice retrovirové replikace
AR035970A1 (es) 2001-05-11 2004-07-28 Tibotec Pharm Ltd 2-amino-benzoxazol sulfonamidas inhibidoras de amplio espectro de la hiv proteasa, composicion farmaceutica, metodo "in vitro" para inhibir la replicacion retroviral, y utilizacion de estos compuestos en la manufactura de medicamentos
AU2002361235B2 (en) 2001-12-21 2008-07-24 Tibotec Pharmaceuticals Ltd. Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl) * 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
WO2004016619A1 (en) * 2002-08-14 2004-02-26 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
US20040203166A1 (en) * 2003-04-11 2004-10-14 Sullivan John Timothy Electrolysis apparatus and method utilizing at least one coiled electrode
ATE353323T1 (de) * 2003-09-30 2007-02-15 Tibotec Pharm Ltd Verfahren zur herstellung von benzoxazolsulfonamidverbindungen und zwischenprodukten davon
PL1725566T3 (pl) 2003-12-23 2009-11-30 Janssen Sciences Ireland Uc Sposób wytwarzania (1s,2r)-3-[[(4-aminofenylo)sulfonylo](izobutylo)amino]-1-benzylo-2-hydroksypropylokarbaminianu (3r,3as,6ar)-heksahydrofuro-[2,3-b]furan-3-ylu
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
ES2426345T3 (es) 2005-07-20 2013-10-22 Eli Lilly And Company Compuesto unidos en posición 1-amino
JP2010501583A (ja) * 2006-08-18 2010-01-21 セコイア、ファーマシューティカルズ、インコーポレイテッド シトクロムｐ４５０を阻害するための組成物および方法
US8569364B2 (en) * 2007-11-28 2013-10-29 Sequoia Pharmaceuticals, Inc. 5-substituted benzofurans as inhibitors of cytochrome P450 2D6
CN109824756B (zh) * 2019-03-19 2022-03-22 山东大学 含有4-(苯磺酰基)哌嗪-2-酮的苯丙氨酸衍生物及其制备方法与应用
CN111205206B (zh) * 2020-02-13 2021-10-22 中国医学科学院医药生物技术研究所 一种包含氨基酸连接链的羰基化合物或其药学上可接受的盐及其制备方法和应用

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US5776971A (en) * 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors

Also Published As

Publication number Publication date
DE69625183T2 (de) 2003-10-09
PT815124E (pt) 2003-04-30
DK0815124T3 (da) 2003-03-17
NO974147L (no) 1997-11-04
CA2215022A1 (en) 1996-09-19
HUP9800518A2 (hu) 1998-06-29
US6214861B1 (en) 2001-04-10
WO1996028465A1 (en) 1996-09-19
PL322179A1 (en) 1998-01-19
CN1149223C (zh) 2004-05-12
CN1183102A (zh) 1998-05-27
EP0815124A1 (en) 1998-01-07
US6063795A (en) 2000-05-16
PL184771B1 (pl) 2002-12-31
ES2190793T3 (es) 2003-08-16
US5972989A (en) 1999-10-26
CZ282397A3 (cs) 1998-02-18
AU5417896A (en) 1996-10-02
JP4124818B2 (ja) 2008-07-23
AU717598B2 (en) 2000-03-30
CZ297676B6 (cs) 2007-03-07
DE69625183D1 (en) 2003-01-16
NO974147D0 (no) 1997-09-09
HUP9800518A3 (en) 1998-09-28
JPH11501920A (ja) 1999-02-16
ATE229033T1 (de) 2002-12-15
CN1530372A (zh) 2004-09-22
MX9706946A (es) 1997-11-29
RU2174519C2 (ru) 2001-10-10
NZ306027A (en) 1999-03-29
EP0815124B1 (en) 2002-12-04

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2007, OBSERVADAS AS CONDICOES LEGAIS.

B24C Patent annual fee: request for for restoration

Free format text: REFERENTE A 14A E 15A ANUIDADE(S).

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE AO DESPACHO 24.3 PUBLICADO NA RPI 2114 DE 12/07/2011.