DK1725566T3 - Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat - Google Patents

Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat

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Publication number
DK1725566T3
DK1725566T3 DK04805020T DK04805020T DK1725566T3 DK 1725566 T3 DK1725566 T3 DK 1725566T3 DK 04805020 T DK04805020 T DK 04805020T DK 04805020 T DK04805020 T DK 04805020T DK 1725566 T3 DK1725566 T3 DK 1725566T3
Authority
DK
Denmark
Prior art keywords
amino
isobutyl
hydroxypropylcarbamate
hexahydrofuro
aminophenyl
Prior art date
Application number
DK04805020T
Other languages
English (en)
Inventor
Nicolaas Martha Felix Goyvaerts
Piet Tom Bert Paul Wigerinck
Hartmut Burghard Zinser
Birgit M Ebert
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34740665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1725566(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of DK1725566T3 publication Critical patent/DK1725566T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04805020T 2003-12-23 2004-12-23 Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat DK1725566T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104949 2003-12-23
US56818304P 2004-05-04 2004-05-04
PCT/EP2004/053692 WO2005063770A1 (en) 2003-12-23 2004-12-23 Process for the preparation of (3r,3as,6ar)-hexahydrofuro [2,3-b] furan-3-yl (1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate

Publications (1)

Publication Number Publication Date
DK1725566T3 true DK1725566T3 (da) 2009-10-05

Family

ID=34740665

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04805020T DK1725566T3 (da) 2003-12-23 2004-12-23 Fremgangsmåde til fremstilling af (3R,3AS, 6AR)-hexahydrofuro [2,3.B] furan-3-yl (1S,2R)-3-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamat

Country Status (21)

Country Link
EP (1) EP1725566B1 (da)
KR (1) KR101192859B1 (da)
CN (1) CN1898248B (da)
AT (1) ATE433982T1 (da)
AU (1) AU2004309122B2 (da)
BR (1) BRPI0417272B8 (da)
CA (1) CA2549460C (da)
CY (1) CY1109379T1 (da)
DE (1) DE602004021640D1 (da)
DK (1) DK1725566T3 (da)
ES (1) ES2328701T3 (da)
HR (1) HRP20090488T1 (da)
IL (1) IL174960A (da)
MX (1) MXPA06007211A (da)
NO (1) NO337636B1 (da)
PL (1) PL1725566T3 (da)
PT (1) PT1725566E (da)
RU (1) RU2376308C2 (da)
SI (1) SI1725566T1 (da)
WO (1) WO2005063770A1 (da)
ZA (1) ZA200605163B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI432438B (zh) 2005-11-28 2014-04-01 Tibotec Pharm Ltd 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物及衍生物
JP5491862B2 (ja) * 2006-11-09 2014-05-14 ヤンセン・アールアンドデイ・アイルランド ヘキサヒドロフロ［２，３−ｂ］フラン−３−オールの製造方法
PT2152667E (pt) * 2007-04-27 2011-04-06 Tibotec Pharm Ltd Processos para a preparação de derivados de n-isobutil-n- (2-hidroxi-3-amino-4-fenilbutil)-p-nitrobenzenosulfonilamida
US8592487B2 (en) 2007-10-26 2013-11-26 Concert Pharmaceuticals, Inc. Deuterated darunavir
CA2703591C (en) * 2007-10-26 2013-05-07 Concert Pharmaceuticals, Inc. Deuterated darunavir
TWI482775B (zh) * 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
DK2426124T3 (da) * 2009-05-13 2013-09-30 Meiji Seika Pharma Co Ltd Fremgangsmåde til fremstilling af pyripyropene derivater
US8703980B2 (en) 2009-09-17 2014-04-22 Siva Rama Prasad Vellanki Process for the preparation of darunavir
NZ600994A (en) 2010-01-05 2014-04-30 Cipla Ltd Darunavir polymorph and process for preparation thereof
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
CN102584844B (zh) * 2011-01-11 2016-04-13 浙江九洲药业股份有限公司 一种达芦那韦晶型及其制备方法
ES2848216T3 (es) 2012-07-24 2021-08-05 Laurus Labs Ltd Un proceso para la preparación de Darunavir
CN103893178B (zh) * 2014-03-19 2016-06-01 中山大学 苯-磺酰胺类化合物在制备抗hiv-1病毒药物中的应用
US20160075643A1 (en) * 2014-09-16 2016-03-17 Zcl Chemicals Limited Novel process to prepare intermediates of hiv-protease inhibitors thereof
US10633390B2 (en) * 2015-06-25 2020-04-28 Msn Laboratories Private Limited Process for the preparation of [(1S,2R)-3-[[(4-aminophenyl)sulfonyl] (2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-carbamic acid (3R,3AS,6AR)hexahydro furo [2,3-B]furan-3-YL ester and its amorphous form
WO2018081292A1 (en) 2016-10-27 2018-05-03 Gilead Sciences, Inc. Crystalline forms of darunavir free base, hydrate, solvates and salts
WO2018091559A1 (en) * 2016-11-17 2018-05-24 Janssen Sciences Ireland Uc A simplified procedure for the preparation of darunavir
CN114685322B (zh) * 2020-12-30 2023-08-25 上海飞腾医药科技有限公司 一种抗hiv类药物中间体晶体的生长方法和所得晶体及其应用
CN113896658A (zh) * 2021-09-24 2022-01-07 上药康丽（常州）药业有限公司 一种利用微通道反应器合成地瑞那韦中间体的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE382041T1 (de) 1995-01-20 2008-01-15 Searle Llc Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5929284A (en) 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU717598B2 (en) 1995-03-10 2000-03-30 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1067125B1 (en) 1999-01-29 2006-07-26 Kaneka Corporation PROCESSES FOR THE PREPARATION OF threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE DERIVATIVES
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
US7622490B2 (en) 2001-05-11 2009-11-24 Tibotec Pharmaceuticals, Ltd. Broadspecturm 2-amino-benzoxazole sulfonamide HIV protease inhibitors
CA2472133A1 (en) * 2001-12-28 2003-07-17 Ajinomoto Co., Inc. Process for producing crystal of benzenesulfonamide derivative, and novel crystal of intermediate therefor and process for producing the same

Also Published As

Publication number Publication date
MXPA06007211A (es) 2006-08-18
EP1725566A1 (en) 2006-11-29
KR101192859B1 (ko) 2012-10-19
BRPI0417272B1 (pt) 2020-08-18
ATE433982T1 (de) 2009-07-15
ES2328701T3 (es) 2009-11-17
SI1725566T1 (sl) 2009-12-31
PL1725566T3 (pl) 2009-11-30
RU2006126670A (ru) 2008-01-27
CA2549460A1 (en) 2005-07-14
IL174960A0 (en) 2006-08-20
AU2004309122B2 (en) 2011-07-21
BRPI0417272A (pt) 2007-03-27
KR20060123740A (ko) 2006-12-04
RU2376308C2 (ru) 2009-12-20
PT1725566E (pt) 2009-09-16
NO20063401L (no) 2006-07-21
DE602004021640D1 (de) 2009-07-30
CA2549460C (en) 2014-08-05
NO337636B1 (no) 2016-05-23
CN1898248A (zh) 2007-01-17
HRP20090488T1 (en) 2009-10-31
BRPI0417272B8 (pt) 2021-05-25
AU2004309122A1 (en) 2005-07-14
CN1898248B (zh) 2011-08-17
EP1725566B1 (en) 2009-06-17
WO2005063770A1 (en) 2005-07-14
CY1109379T1 (el) 2014-07-02
IL174960A (en) 2011-06-30
ZA200605163B (en) 2007-12-27

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