NO20061951L - Fremgangsmater for fremstillingen av benzoksazol-sulfonamid-forbindelser og intermediater derav - Google Patents

Fremgangsmater for fremstillingen av benzoksazol-sulfonamid-forbindelser og intermediater derav

Info

Publication number
NO20061951L
NO20061951L NO20061951A NO20061951A NO20061951L NO 20061951 L NO20061951 L NO 20061951L NO 20061951 A NO20061951 A NO 20061951A NO 20061951 A NO20061951 A NO 20061951A NO 20061951 L NO20061951 L NO 20061951L
Authority
NO
Norway
Prior art keywords
benzoxazole
preparation
sulfonamide compounds
intermediates
processes
Prior art date
Application number
NO20061951A
Other languages
English (en)
Inventor
Herman Augustinus De Kock
Walter Ferdinand Mari Filliers
Wim Albert Alex Aelterman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20061951L publication Critical patent/NO20061951L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører fremgangsmåter for fremstillingen av benzoksazol-sulfonamid-forbindelser så vel som nye intermediater for anvendelse i nevnte fremgangsmåte. Mer spesielt vedrører oppfinnelsen fremgangsmåter for fremstillingen av 2-amino-benzoksazol-sulfonamid-forbindelser som nytter anvendelse av 2-merkapto-benzoksazol sulfonamid intermediater, mer spesielt fremgangsmåter som anvender intermediatet l-benzyl-2-hydroksy-3-[isobutyl-(2-metylsulfanyl-benzoksazol-6-sulfonyl)-amino]-propyl)-karbamidester, og to fremgangsmåter egnet for industriell oppskalering.Nevnte benzoksazol-sulfonamid-forbindelser er spesielt nyttige som HrV-proteaseinhibitorer.
NO20061951A 2003-09-30 2006-05-02 Fremgangsmater for fremstillingen av benzoksazol-sulfonamid-forbindelser og intermediater derav NO20061951L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103630 2003-09-30
US50799603P 2003-10-02 2003-10-02
PCT/EP2004/052382 WO2005030739A1 (en) 2003-09-30 2004-09-30 Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof

Publications (1)

Publication Number Publication Date
NO20061951L true NO20061951L (no) 2006-05-02

Family

ID=34395298

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061951A NO20061951L (no) 2003-09-30 2006-05-02 Fremgangsmater for fremstillingen av benzoksazol-sulfonamid-forbindelser og intermediater derav

Country Status (24)

Country Link
US (1) US20070123574A1 (no)
EP (1) EP1670773B1 (no)
JP (1) JP4919802B2 (no)
KR (1) KR101090102B1 (no)
CN (1) CN1860107B (no)
AP (1) AP1985A (no)
AT (1) ATE353323T1 (no)
AU (1) AU2004276017B2 (no)
BR (1) BRPI0414916A (no)
CA (1) CA2537877C (no)
DE (1) DE602004004674T2 (no)
DK (1) DK1670773T3 (no)
EA (1) EA011891B1 (no)
ES (1) ES2281828T3 (no)
IL (1) IL173891A0 (no)
IN (1) IN2012DN02301A (no)
MX (1) MXPA06003575A (no)
NO (1) NO20061951L (no)
NZ (1) NZ546279A (no)
PL (1) PL1670773T3 (no)
PT (1) PT1670773E (no)
SI (1) SI1670773T1 (no)
WO (1) WO2005030739A1 (no)
ZA (1) ZA200602603B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
US9067949B2 (en) 2011-01-19 2015-06-30 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
RU2174519C2 (ru) * 1995-03-10 2001-10-10 Джи. Ди. Сирл Энд Ко. Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу
WO1997018205A1 (en) * 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6548667B2 (en) * 2000-04-07 2003-04-15 Samsung Electronics Co. Ltd. Sulfonamide derivative as a matrix metalloproteinase inhibitor
US6455738B1 (en) * 2000-07-13 2002-09-24 Rhodia Chimie Process for the sulfonation of an aromatic compound
BR0207862A (pt) * 2001-02-14 2004-06-22 Tibotec Pharm Ltd Inibidores de protease de hiv 2-(amino-substituìda)-benzotiazol-sulfonamida de amplo espectro
AR035970A1 (es) * 2001-05-11 2004-07-28 Tibotec Pharm Ltd 2-amino-benzoxazol sulfonamidas inhibidoras de amplio espectro de la hiv proteasa, composicion farmaceutica, metodo "in vitro" para inhibir la replicacion retroviral, y utilizacion de estos compuestos en la manufactura de medicamentos
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
MY142238A (en) * 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors

Also Published As

Publication number Publication date
IN2012DN02301A (no) 2015-08-14
CN1860107B (zh) 2013-08-21
BRPI0414916A (pt) 2006-11-07
ZA200602603B (en) 2008-05-28
JP2007507468A (ja) 2007-03-29
SI1670773T1 (sl) 2007-06-30
CN1860107A (zh) 2006-11-08
EP1670773B1 (en) 2007-02-07
CA2537877A1 (en) 2005-04-07
EA200600699A1 (ru) 2006-08-25
CA2537877C (en) 2015-03-17
ES2281828T3 (es) 2007-10-01
AU2004276017B2 (en) 2010-08-19
DE602004004674D1 (de) 2007-03-22
PT1670773E (pt) 2007-05-31
US20070123574A1 (en) 2007-05-31
AU2004276017A1 (en) 2005-04-07
MXPA06003575A (es) 2006-06-05
NZ546279A (en) 2008-09-26
IL173891A0 (en) 2006-07-05
ATE353323T1 (de) 2007-02-15
AP2006003603A0 (en) 2006-04-30
KR101090102B1 (ko) 2011-12-07
EA011891B1 (ru) 2009-06-30
JP4919802B2 (ja) 2012-04-18
EP1670773A1 (en) 2006-06-21
PL1670773T3 (pl) 2007-06-29
DK1670773T3 (da) 2007-05-29
KR20060092224A (ko) 2006-08-22
WO2005030739A1 (en) 2005-04-07
AP1985A (en) 2009-03-30
DE602004004674T2 (de) 2007-11-22

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