NO20054442L - Pyrrolidinderivater som oksytocinantagonister - Google Patents
Pyrrolidinderivater som oksytocinantagonisterInfo
- Publication number
- NO20054442L NO20054442L NO20054442A NO20054442A NO20054442L NO 20054442 L NO20054442 L NO 20054442L NO 20054442 A NO20054442 A NO 20054442A NO 20054442 A NO20054442 A NO 20054442A NO 20054442 L NO20054442 L NO 20054442L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- heteroaryl
- alkynyl
- alkenyl
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Foreliggende oppfinnelse angår nye pyrrolidinderivater med formel (I), deres geometriske isomerer, deres optisk aktive former som enantiomerer, diastereomerer, blandinger av disse og deres racematformer så vel som salter av disse, hvor: R1 er valgt fra gruppen som omfatter eller består av H og Cj-C6-alkyl; R2 er valgt fra gruppen som omfatter eller består av hydrogen, C1-C6-alkyl, aryl, C]-C6-alkylaryl, heteroaryl, C1-C6-alkylheteroaryl, C2-C6-alkylheteroaryl, C2-C6-alkenyl, C2-C6-alkenylaryl, C2-C6-alkenylheteroaryl, C2-C6-alkynyl, C2-C6-alkynylaryl, C2-C6-alkynylheteroaryl, C3-Cg-sykloalkyl, heterosykloalkyl, C1-C6-alkylsykloalkyl, Ci-C6-alkylheterosykloalkyl, Cj-Cé-alkylkarboksy, acyl, Ci-Cé-alkylacyl, C1-C6-alkylacyloksy, Ci-C6-alkylalkoksy, alkoksykarbonyl, Ci-C6-alkylalkoksykarbonyl, aminokarbonyl, C1-C6-alkylaminokarbonyl, Ci-C6-alkylacylamino, C1-C6-alkylureido, amino, Ci-C6-alkylamino, sulfonyloksy, Ci-C6-alkylsulfonyloksy, sulfonyl, Ci-C6-alkylsulfonyl, sulfinyl, Ci-Cé-alkylsulfinyl, Ci-Cé-alkylsulfanyl, Ci-C6-alkylsulfonylamino.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03100477 | 2003-02-27 | ||
| PCT/EP2004/050142 WO2004076407A2 (en) | 2003-02-27 | 2004-02-16 | Pyrrolidine derivatives as oxytocin antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20054442L true NO20054442L (no) | 2005-09-26 |
Family
ID=32921609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054442A NO20054442L (no) | 2003-02-27 | 2005-09-26 | Pyrrolidinderivater som oksytocinantagonister |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7557136B2 (no) |
| EP (1) | EP1597229B1 (no) |
| JP (1) | JP4773335B2 (no) |
| AT (1) | ATE449067T1 (no) |
| AU (1) | AU2004215661B2 (no) |
| CA (1) | CA2515546C (no) |
| DE (1) | DE602004024170D1 (no) |
| ES (1) | ES2333719T3 (no) |
| NO (1) | NO20054442L (no) |
| WO (1) | WO2004076407A2 (no) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2845850A1 (en) | 2013-09-10 | 2015-03-11 | ObsEva S.A. | Pyrrolidine derivatives as oxytocin/vasopressin V1a receptors antagonists |
| EP2886107A1 (en) * | 2013-12-17 | 2015-06-24 | ObsEva S.A. | Oral formulations of pyrrolydine derivatives |
| CA2953722C (en) | 2014-07-02 | 2022-09-13 | ObsEva SA | Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same |
| CN115073344B (zh) * | 2022-06-24 | 2024-03-26 | 苏州富士莱医药股份有限公司 | 一种r-(1-叔丁氧羰基吡咯烷-2-基)丙烯酸的制备方法及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2401242A1 (en) * | 2000-03-27 | 2001-10-04 | Applied Research Systems Ars Holding N.V. | Pharmaceutically active pyrrolidine derivatives |
| EP1390347B1 (en) | 2001-03-20 | 2008-05-07 | Laboratoires Serono SA | Pyrrolidine ester derivatives with oxytocin modulating activity |
| IL159219A0 (en) * | 2001-06-18 | 2004-06-01 | Applied Research Systems | Pyrrolidine oxadiazole derivatives, their preparation and pharmaceutical compositions containing them |
-
2004
- 2004-02-16 AU AU2004215661A patent/AU2004215661B2/en not_active Ceased
- 2004-02-16 EP EP04711384A patent/EP1597229B1/en not_active Expired - Lifetime
- 2004-02-16 US US10/547,032 patent/US7557136B2/en not_active Expired - Fee Related
- 2004-02-16 WO PCT/EP2004/050142 patent/WO2004076407A2/en active Application Filing
- 2004-02-16 AT AT04711384T patent/ATE449067T1/de not_active IP Right Cessation
- 2004-02-16 ES ES04711384T patent/ES2333719T3/es not_active Expired - Lifetime
- 2004-02-16 CA CA2515546A patent/CA2515546C/en not_active Expired - Fee Related
- 2004-02-16 JP JP2006502031A patent/JP4773335B2/ja not_active Expired - Fee Related
- 2004-02-16 DE DE602004024170T patent/DE602004024170D1/de not_active Expired - Lifetime
-
2005
- 2005-09-26 NO NO20054442A patent/NO20054442L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004076407A3 (en) | 2004-10-21 |
| US7557136B2 (en) | 2009-07-07 |
| AU2004215661A1 (en) | 2004-09-10 |
| AU2004215661B2 (en) | 2009-12-03 |
| US20070037806A1 (en) | 2007-02-15 |
| EP1597229B1 (en) | 2009-11-18 |
| ES2333719T3 (es) | 2010-02-26 |
| DE602004024170D1 (de) | 2009-12-31 |
| JP2006519212A (ja) | 2006-08-24 |
| CA2515546A1 (en) | 2004-09-10 |
| ATE449067T1 (de) | 2009-12-15 |
| EP1597229A2 (en) | 2005-11-23 |
| WO2004076407A2 (en) | 2004-09-10 |
| JP4773335B2 (ja) | 2011-09-14 |
| CA2515546C (en) | 2011-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: ONSAGERS AS, POSTBOKS 6963 ST OLAVS PLASS, 0130 OS |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |