AR039937A1 - Derivados de azetidina como inhibidores de tripsina proteasas - Google Patents

Derivados de azetidina como inhibidores de tripsina proteasas

Info

Publication number
AR039937A1
AR039937A1 ARP030101935A ARP030101935A AR039937A1 AR 039937 A1 AR039937 A1 AR 039937A1 AR P030101935 A ARP030101935 A AR P030101935A AR P030101935 A ARP030101935 A AR P030101935A AR 039937 A1 AR039937 A1 AR 039937A1
Authority
AR
Argentina
Prior art keywords
inhibitors
tripsine
azetidine
proteases
derivatives
Prior art date
Application number
ARP030101935A
Other languages
English (en)
Inventor
Matti Ahlqvist
Martin Bohlin
Tord Inghardt
Carl-Gustav Sigfridsson
Anita I Lundblad
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR039937A1 publication Critical patent/AR039937A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Sales de adición ácida aceptables para uso farmacéutico de compuestos de fórmula (1), donde R1 representa C1-2 alquilo sustituido por uno o más sustituyentes fluoro; R2 representa C1-2 alquilo; y n representa 0, 1 o 2, donde las sales son útiles como prodrogas de inhibidores competitivos de tripsina proteasas tales como la trombina, y por consiguiente, en particular, en el tratamiento de trastornos en la que requiere de la inhibición de la trombina (por ejemplo, trombosis), o como anticoagulantes.
ARP030101935A 2002-05-31 2003-05-30 Derivados de azetidina como inhibidores de tripsina proteasas AR039937A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0201661A SE0201661D0 (sv) 2002-05-31 2002-05-31 New salts

Publications (1)

Publication Number Publication Date
AR039937A1 true AR039937A1 (es) 2005-03-09

Family

ID=20288039

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101935A AR039937A1 (es) 2002-05-31 2003-05-30 Derivados de azetidina como inhibidores de tripsina proteasas

Country Status (31)

Country Link
US (2) US7273858B2 (es)
EP (2) EP1513806B1 (es)
JP (1) JP4541140B2 (es)
KR (1) KR20050009726A (es)
CN (2) CN1656067A (es)
AR (1) AR039937A1 (es)
AT (1) ATE425963T1 (es)
AU (1) AU2003232871B2 (es)
BR (1) BR0311365A (es)
CA (1) CA2487509A1 (es)
CY (1) CY1109085T1 (es)
DE (1) DE60326720D1 (es)
DK (1) DK1513806T3 (es)
ES (1) ES2322048T3 (es)
HK (1) HK1073102A1 (es)
IL (1) IL165295A0 (es)
IS (1) IS7598A (es)
MX (1) MXPA04011912A (es)
MY (1) MY133333A (es)
NO (1) NO329064B1 (es)
NZ (2) NZ536738A (es)
PL (1) PL373794A1 (es)
PT (1) PT1513806E (es)
RU (2) RU2345064C2 (es)
SA (1) SA03240440B1 (es)
SE (1) SE0201661D0 (es)
SI (1) SI1513806T1 (es)
TW (2) TWI313173B (es)
UA (1) UA81246C2 (es)
WO (1) WO2003101957A1 (es)
ZA (1) ZA200409228B (es)

Families Citing this family (10)

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SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
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TW200900033A (en) * 2007-06-21 2009-01-01 Wen-Qing Li Automatic brewing machine
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

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Also Published As

Publication number Publication date
SE0201661D0 (sv) 2002-05-31
UA81246C2 (en) 2007-12-25
WO2003101957A1 (en) 2003-12-11
US7763597B2 (en) 2010-07-27
SA03240440B1 (ar) 2008-02-24
DK1513806T3 (da) 2009-06-15
IS7598A (is) 2004-12-15
TWI367754B (en) 2012-07-11
AU2003232871A1 (en) 2003-12-19
US20080269176A1 (en) 2008-10-30
SI1513806T1 (sl) 2009-06-30
RU2008127541A (ru) 2010-01-20
HK1073102A1 (en) 2005-09-23
DE60326720D1 (de) 2009-04-30
PT1513806E (pt) 2009-05-04
US7273858B2 (en) 2007-09-25
BR0311365A (pt) 2005-03-01
EP2055696A1 (en) 2009-05-06
RU2345064C2 (ru) 2009-01-27
NZ536738A (en) 2007-05-31
MY133333A (en) 2007-11-30
NZ554323A (en) 2008-10-31
PL373794A1 (en) 2005-09-19
TW200927094A (en) 2009-07-01
NO329064B1 (no) 2010-08-09
EP1513806A1 (en) 2005-03-16
KR20050009726A (ko) 2005-01-25
JP4541140B2 (ja) 2010-09-08
CN101735131A (zh) 2010-06-16
RU2004133388A (ru) 2005-07-10
CY1109085T1 (el) 2012-05-23
AU2003232871B2 (en) 2010-08-19
ES2322048T3 (es) 2009-06-16
TW200402293A (en) 2004-02-16
CA2487509A1 (en) 2003-12-11
NO20044867L (no) 2004-12-23
JP2005532346A (ja) 2005-10-27
MXPA04011912A (es) 2005-03-31
ATE425963T1 (de) 2009-04-15
CN1656067A (zh) 2005-08-17
TWI313173B (en) 2009-08-11
US20050234035A1 (en) 2005-10-20
IL165295A0 (en) 2005-12-18
EP1513806B1 (en) 2009-03-18
ZA200409228B (en) 2005-05-17

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