BR0311365A - Sal de adição de ácido farmaceuticamente aceitável, processo para a preparação de um sal de adição de ácido formulação farmacêutica, uso de um sal de adição de ácido, e, método de tratamento de uma condição onde a inibição da trombina é requerida - Google Patents
Sal de adição de ácido farmaceuticamente aceitável, processo para a preparação de um sal de adição de ácido formulação farmacêutica, uso de um sal de adição de ácido, e, método de tratamento de uma condição onde a inibição da trombina é requeridaInfo
- Publication number
- BR0311365A BR0311365A BR0311365-5A BR0311365A BR0311365A BR 0311365 A BR0311365 A BR 0311365A BR 0311365 A BR0311365 A BR 0311365A BR 0311365 A BR0311365 A BR 0311365A
- Authority
- BR
- Brazil
- Prior art keywords
- acid addition
- addition salt
- pharmaceutically acceptable
- treating
- condition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
"SAL DE ADIçãO DE áCIDO FARMACEUTICAMENTE ACEITáVEL, PROCESSO PARA A PREPARAçãO DE UM SAL DE ADIçãO DE áCIDO FORMULAçãO FARMACêUTICA, USO DE UM SAL DE ADIçãO DE áCIDO, E, MéTODO DE TRATAMENTO DE UMA CONDIçãO ONDE A INIBIçãO DA TROMBINA é REQUERIDA". São fornecidos sais de adição de ácido farmaceuticamente aceitáveis de compostos de fórmula (I) em que R^ 1^ representa alquila C~ 1-2~ substituída com um ou mais substituintes de fluoro; R^ 2^ representa alquila C~ 1-2~; e n representa 0, 1 ou 2, cujos sais são úteis como pró-medicamentos de inibidores competitivos das proteases semelhantes a tripsina, tais como trombina, e por conseguinte, em particular, no tratamento de condições onde a inibição da trombina é requerida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201661A SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | New salts |
PCT/SE2003/000859 WO2003101957A1 (en) | 2002-05-31 | 2003-05-27 | New salts |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0311365A true BR0311365A (pt) | 2005-03-01 |
Family
ID=20288039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0311365-5A BR0311365A (pt) | 2002-05-31 | 2003-05-27 | Sal de adição de ácido farmaceuticamente aceitável, processo para a preparação de um sal de adição de ácido formulação farmacêutica, uso de um sal de adição de ácido, e, método de tratamento de uma condição onde a inibição da trombina é requerida |
Country Status (31)
Country | Link |
---|---|
US (2) | US7273858B2 (pt) |
EP (2) | EP2055696A1 (pt) |
JP (1) | JP4541140B2 (pt) |
KR (1) | KR20050009726A (pt) |
CN (2) | CN1656067A (pt) |
AR (1) | AR039937A1 (pt) |
AT (1) | ATE425963T1 (pt) |
AU (1) | AU2003232871B2 (pt) |
BR (1) | BR0311365A (pt) |
CA (1) | CA2487509A1 (pt) |
CY (1) | CY1109085T1 (pt) |
DE (1) | DE60326720D1 (pt) |
DK (1) | DK1513806T3 (pt) |
ES (1) | ES2322048T3 (pt) |
HK (1) | HK1073102A1 (pt) |
IL (1) | IL165295A0 (pt) |
IS (1) | IS7598A (pt) |
MX (1) | MXPA04011912A (pt) |
MY (1) | MY133333A (pt) |
NO (1) | NO329064B1 (pt) |
NZ (2) | NZ536738A (pt) |
PL (1) | PL373794A1 (pt) |
PT (1) | PT1513806E (pt) |
RU (2) | RU2345064C2 (pt) |
SA (1) | SA03240440B1 (pt) |
SE (1) | SE0201661D0 (pt) |
SI (1) | SI1513806T1 (pt) |
TW (2) | TWI313173B (pt) |
UA (1) | UA81246C2 (pt) |
WO (1) | WO2003101957A1 (pt) |
ZA (1) | ZA200409228B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
RU2328501C1 (ru) * | 2004-04-09 | 2008-07-10 | Ханми Фарм. Ко., ЛТД | Кристаллический клопидогрель нафталинсульфонат или его гидрат, способ его получения и содержащая его фармацевтическая композиция |
JP2007533746A (ja) * | 2004-04-20 | 2007-11-22 | サノフイ−アベンテイス | クロピドグレル塩及びその多形型 |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
TW200900033A (en) * | 2007-06-21 | 2009-01-01 | Wen-Qing Li | Automatic brewing machine |
US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
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JPS57149217A (en) | 1981-03-11 | 1982-09-14 | Kaken Pharmaceut Co Ltd | Slow-releasing pharmaceutical preparation |
HU192646B (en) * | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
ZA86746B (en) | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US4792452A (en) | 1987-07-28 | 1988-12-20 | E. R. Squibb & Sons, Inc. | Controlled release formulation |
EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
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IT1229491B (it) * | 1988-12-28 | 1991-09-03 | Roussel Maestretti S P A Ora R | Derivati della 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro impiego come sostanze medicinali |
TW201303B (pt) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
US5169638A (en) | 1991-10-23 | 1992-12-08 | E. R. Squibb & Sons, Inc. | Buoyant controlled release powder formulation |
ZA928581B (en) | 1991-11-12 | 1994-05-06 | Lilly Co Eli | Antithrombotic agents |
SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
AU663169B2 (en) | 1992-03-04 | 1995-09-28 | Gyogyszerkutato Intezet Kft | New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof |
TW223629B (pt) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5783563A (en) | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
SE9301912D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | Process for the production of aminoalkylguandines |
EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
CA2140598C (en) | 1994-01-27 | 2010-03-09 | Masahiro Ohshima | Prolineamide derivatives |
IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
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SE9802938D0 (sv) | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
SE9802974D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
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SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
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SE9902550D0 (sv) | 1999-07-02 | 1999-07-02 | Astra Ab | New crystalline forms |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
IL154077A0 (en) | 2000-08-16 | 2003-07-31 | Astrazeneca Ab | New amidino derivatives and their use as thrombin inhibitors |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
SE0102921D0 (sv) | 2001-08-30 | 2001-08-30 | Astrazeneca Ab | Pharmaceutically useful compounds |
US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
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AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
US6811794B2 (en) * | 2001-12-20 | 2004-11-02 | Shire Laboratories, Inc. | Sustained release pharmaceutical dosage forms with minimized pH dependent dissolution profiles |
SE0201658D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
SE0201659D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
SE0303220D0 (sv) * | 2003-11-28 | 2003-11-28 | Astrazeneca Ab | New process |
GB0503672D0 (en) * | 2005-02-23 | 2005-03-30 | Astrazeneca Ab | New process |
GB0510546D0 (en) * | 2005-05-24 | 2005-06-29 | Astrazeneca Ab | New process |
TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
-
2002
- 2002-05-31 SE SE0201661A patent/SE0201661D0/xx unknown
-
2003
- 2003-05-27 BR BR0311365-5A patent/BR0311365A/pt not_active IP Right Cessation
- 2003-05-27 DE DE60326720T patent/DE60326720D1/de not_active Expired - Lifetime
- 2003-05-27 CA CA002487509A patent/CA2487509A1/en not_active Abandoned
- 2003-05-27 AU AU2003232871A patent/AU2003232871B2/en not_active Ceased
- 2003-05-27 SI SI200331578T patent/SI1513806T1/sl unknown
- 2003-05-27 JP JP2004509651A patent/JP4541140B2/ja not_active Expired - Fee Related
- 2003-05-27 ES ES03728206T patent/ES2322048T3/es not_active Expired - Lifetime
- 2003-05-27 UA UA20041109441A patent/UA81246C2/uk unknown
- 2003-05-27 KR KR10-2004-7019439A patent/KR20050009726A/ko not_active Application Discontinuation
- 2003-05-27 PL PL03373794A patent/PL373794A1/xx not_active Application Discontinuation
- 2003-05-27 US US10/516,422 patent/US7273858B2/en not_active Expired - Fee Related
- 2003-05-27 EP EP09151657A patent/EP2055696A1/en not_active Withdrawn
- 2003-05-27 CN CNA038124912A patent/CN1656067A/zh active Pending
- 2003-05-27 AT AT03728206T patent/ATE425963T1/de not_active IP Right Cessation
- 2003-05-27 DK DK03728206T patent/DK1513806T3/da active
- 2003-05-27 IL IL16529503A patent/IL165295A0/xx unknown
- 2003-05-27 MX MXPA04011912A patent/MXPA04011912A/es active IP Right Grant
- 2003-05-27 NZ NZ536738A patent/NZ536738A/en not_active IP Right Cessation
- 2003-05-27 WO PCT/SE2003/000859 patent/WO2003101957A1/en active Application Filing
- 2003-05-27 RU RU2004133388/04A patent/RU2345064C2/ru not_active IP Right Cessation
- 2003-05-27 PT PT03728206T patent/PT1513806E/pt unknown
- 2003-05-27 CN CN200910260483A patent/CN101735131A/zh active Pending
- 2003-05-27 NZ NZ554323A patent/NZ554323A/en not_active IP Right Cessation
- 2003-05-27 EP EP03728206A patent/EP1513806B1/en not_active Expired - Lifetime
- 2003-05-29 MY MYPI20031981A patent/MY133333A/en unknown
- 2003-05-30 TW TW092114807A patent/TWI313173B/zh active
- 2003-05-30 AR ARP030101935A patent/AR039937A1/es unknown
- 2003-05-30 TW TW097151265A patent/TWI367754B/zh not_active IP Right Cessation
- 2003-12-10 SA SA3240440A patent/SA03240440B1/ar unknown
-
2004
- 2004-11-09 NO NO20044867A patent/NO329064B1/no not_active IP Right Cessation
- 2004-11-17 ZA ZA200409228A patent/ZA200409228B/en unknown
- 2004-12-15 IS IS7598A patent/IS7598A/is unknown
-
2005
- 2005-06-20 HK HK05105118.1A patent/HK1073102A1/xx not_active IP Right Cessation
-
2007
- 2007-08-16 US US11/839,842 patent/US7763597B2/en not_active Expired - Fee Related
-
2008
- 2008-07-09 RU RU2008127541/04A patent/RU2008127541A/ru not_active Application Discontinuation
-
2009
- 2009-05-20 CY CY20091100535T patent/CY1109085T1/el unknown
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