DK1556371T3 - Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer - Google Patents

Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer

Info

Publication number
DK1556371T3
DK1556371T3 DK03765694T DK03765694T DK1556371T3 DK 1556371 T3 DK1556371 T3 DK 1556371T3 DK 03765694 T DK03765694 T DK 03765694T DK 03765694 T DK03765694 T DK 03765694T DK 1556371 T3 DK1556371 T3 DK 1556371T3
Authority
DK
Denmark
Prior art keywords
proton pump
pump inhibitor
benzimidazole derivatives
inhibitor prodrugs
prodrugs
Prior art date
Application number
DK03765694T
Other languages
English (en)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Winston Pharmaceuticals Llc
Univ California
Us Gov Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winston Pharmaceuticals Llc, Univ California, Us Gov Veterans Affairs filed Critical Winston Pharmaceuticals Llc
Application granted granted Critical
Publication of DK1556371T3 publication Critical patent/DK1556371T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DK03765694T 2002-07-19 2003-07-15 Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer DK1556371T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19

Publications (1)

Publication Number Publication Date
DK1556371T3 true DK1556371T3 (da) 2006-08-21

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03765694T DK1556371T3 (da) 2002-07-19 2003-07-15 Benzimidazol-derivater og deres anvendelse som prodrugs for protonpumpe-inhibitorer

Country Status (23)

Country Link
US (3) US6897227B2 (da)
EP (1) EP1556371B1 (da)
JP (1) JP4463103B2 (da)
KR (2) KR100822981B1 (da)
AT (1) ATE323695T1 (da)
AU (1) AU2003259154B2 (da)
BR (1) BR0312802A (da)
CA (1) CA2492718C (da)
CO (1) CO5690576A2 (da)
DE (1) DE60304726T2 (da)
DK (1) DK1556371T3 (da)
ES (1) ES2263028T3 (da)
HK (1) HK1079207A1 (da)
IL (1) IL166371A0 (da)
MX (1) MXPA05000657A (da)
NO (1) NO20050801L (da)
NZ (1) NZ538221A (da)
PL (1) PL375255A1 (da)
PT (1) PT1556371E (da)
RU (1) RU2292342C2 (da)
TW (1) TW200502231A (da)
WO (1) WO2004009583A2 (da)
ZA (1) ZA200501116B (da)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
MXPA06000410A (es) * 2003-07-15 2006-03-17 Allergan Inc Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones.
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
JP2007523163A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
US20090048302A1 (en) * 2004-03-11 2009-02-19 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
EP1740571B1 (en) 2004-04-28 2009-07-29 Hetero Drugs Limited A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
NZ572007A (en) * 2006-05-09 2010-12-24 Astrazeneca Ab Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
MX2013007295A (es) 2010-12-23 2013-08-26 Merck Sharp & Dohme Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.
EP2661265B1 (en) 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
CN107405338A (zh) * 2015-01-09 2017-11-28 加州大学评议会 用于治疗胃肠道感染的组合物和方法
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
HUT62882A (en) 1990-06-20 1993-06-28 Astra Ab Process for producing dialkoxy pyridylmethyl sulfinyl benzimidazole derivatives and pharmaceutical compositions comprising same
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
CZ288079B6 (cs) * 1994-06-10 2001-04-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Thiopyridinové deriváty a jejich použití
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
TR200100431T2 (tr) * 1998-08-10 2001-06-21 Partnership Of Michael E. Garst, George Sachs & Jai Moo Proton pompalama önleyici ilaçlar
US6093734A (en) 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
ES2537540T3 (es) * 1998-08-12 2015-06-09 Gilead Sciences, Inc. Método de fabricación de nucleósidos de 1,3-dioxolano y 1,3-oxatiolano
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
WO2002030920A1 (fr) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Composes derives de benzimidazole, leur procede de production et leur utilisation

Also Published As

Publication number Publication date
NO20050801L (no) 2005-02-15
US6897227B2 (en) 2005-05-24
CA2492718C (en) 2010-12-21
AU2003259154B2 (en) 2006-12-07
US20040102484A1 (en) 2004-05-27
PT1556371E (pt) 2006-09-29
WO2004009583A2 (en) 2004-01-29
EP1556371B1 (en) 2006-04-19
BR0312802A (pt) 2005-04-19
DE60304726T2 (de) 2007-08-09
KR100788778B1 (ko) 2007-12-27
IL166371A0 (en) 2006-01-16
DE60304726D1 (de) 2006-05-24
KR20070005029A (ko) 2007-01-09
ES2263028T3 (es) 2006-12-01
HK1079207A1 (en) 2006-03-31
CO5690576A2 (es) 2006-10-31
ZA200501116B (en) 2006-11-29
JP4463103B2 (ja) 2010-05-12
US20050182101A1 (en) 2005-08-18
ATE323695T1 (de) 2006-05-15
KR100822981B1 (ko) 2008-04-16
MXPA05000657A (es) 2005-08-19
NZ538221A (en) 2006-11-30
TW200502231A (en) 2005-01-16
AU2003259154C1 (en) 2004-02-09
US20050143423A1 (en) 2005-06-30
JP2005536519A (ja) 2005-12-02
EP1556371A2 (en) 2005-07-27
CA2492718A1 (en) 2004-01-29
KR20050047078A (ko) 2005-05-19
RU2292342C2 (ru) 2007-01-27
RU2005105564A (ru) 2005-10-10
AU2003259154A1 (en) 2004-02-09
PL375255A1 (en) 2005-11-28
WO2004009583A3 (en) 2004-03-18

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