TW200502231A - Prodrugs of proton pump inhibitors - Google Patents

Prodrugs of proton pump inhibitors

Info

Publication number
TW200502231A
TW200502231A TW092131253A TW92131253A TW200502231A TW 200502231 A TW200502231 A TW 200502231A TW 092131253 A TW092131253 A TW 092131253A TW 92131253 A TW92131253 A TW 92131253A TW 200502231 A TW200502231 A TW 200502231A
Authority
TW
Taiwan
Prior art keywords
prodrugs
pump inhibitors
proton pump
proton
bioavailability
Prior art date
Application number
TW092131253A
Other languages
English (en)
Inventor
Michael Garst
George Sachs
Jai M Shin
Original Assignee
Winston Pharmaceuticals Llc
U S Government Represented By The Dept Of Veteran
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winston Pharmaceuticals Llc, U S Government Represented By The Dept Of Veteran, Univ California filed Critical Winston Pharmaceuticals Llc
Publication of TW200502231A publication Critical patent/TW200502231A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
TW092131253A 2002-07-19 2003-11-07 Prodrugs of proton pump inhibitors TW200502231A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
US10/620,252 US6897227B2 (en) 2002-07-19 2003-07-15 Prodrugs of proton pump inhibitors

Publications (1)

Publication Number Publication Date
TW200502231A true TW200502231A (en) 2005-01-16

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092131253A TW200502231A (en) 2002-07-19 2003-11-07 Prodrugs of proton pump inhibitors

Country Status (23)

Country Link
US (3) US6897227B2 (zh)
EP (1) EP1556371B1 (zh)
JP (1) JP4463103B2 (zh)
KR (2) KR100822981B1 (zh)
AT (1) ATE323695T1 (zh)
AU (1) AU2003259154B2 (zh)
BR (1) BR0312802A (zh)
CA (1) CA2492718C (zh)
CO (1) CO5690576A2 (zh)
DE (1) DE60304726T2 (zh)
DK (1) DK1556371T3 (zh)
ES (1) ES2263028T3 (zh)
HK (1) HK1079207A1 (zh)
IL (1) IL166371A0 (zh)
MX (1) MXPA05000657A (zh)
NO (1) NO20050801L (zh)
NZ (1) NZ538221A (zh)
PL (1) PL375255A1 (zh)
PT (1) PT1556371E (zh)
RU (1) RU2292342C2 (zh)
TW (1) TW200502231A (zh)
WO (1) WO2004009583A2 (zh)
ZA (1) ZA200501116B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
MXPA06000410A (es) * 2003-07-15 2006-03-17 Allergan Inc Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones.
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
JP2007523163A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
US20090048302A1 (en) * 2004-03-11 2009-02-19 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
EP1740571B1 (en) 2004-04-28 2009-07-29 Hetero Drugs Limited A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
NZ572007A (en) * 2006-05-09 2010-12-24 Astrazeneca Ab Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
MX2013007295A (es) 2010-12-23 2013-08-26 Merck Sharp & Dohme Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.
EP2661265B1 (en) 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
CN107405338A (zh) * 2015-01-09 2017-11-28 加州大学评议会 用于治疗胃肠道感染的组合物和方法
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
HUT62882A (en) 1990-06-20 1993-06-28 Astra Ab Process for producing dialkoxy pyridylmethyl sulfinyl benzimidazole derivatives and pharmaceutical compositions comprising same
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
CZ288079B6 (cs) * 1994-06-10 2001-04-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Thiopyridinové deriváty a jejich použití
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
TR200100431T2 (tr) * 1998-08-10 2001-06-21 Partnership Of Michael E. Garst, George Sachs & Jai Moo Proton pompalama önleyici ilaçlar
US6093734A (en) 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
ES2537540T3 (es) * 1998-08-12 2015-06-09 Gilead Sciences, Inc. Método de fabricación de nucleósidos de 1,3-dioxolano y 1,3-oxatiolano
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
WO2002030920A1 (fr) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Composes derives de benzimidazole, leur procede de production et leur utilisation

Also Published As

Publication number Publication date
NO20050801L (no) 2005-02-15
US6897227B2 (en) 2005-05-24
CA2492718C (en) 2010-12-21
AU2003259154B2 (en) 2006-12-07
US20040102484A1 (en) 2004-05-27
PT1556371E (pt) 2006-09-29
WO2004009583A2 (en) 2004-01-29
EP1556371B1 (en) 2006-04-19
BR0312802A (pt) 2005-04-19
DE60304726T2 (de) 2007-08-09
KR100788778B1 (ko) 2007-12-27
IL166371A0 (en) 2006-01-16
DE60304726D1 (de) 2006-05-24
KR20070005029A (ko) 2007-01-09
ES2263028T3 (es) 2006-12-01
HK1079207A1 (en) 2006-03-31
CO5690576A2 (es) 2006-10-31
ZA200501116B (en) 2006-11-29
JP4463103B2 (ja) 2010-05-12
US20050182101A1 (en) 2005-08-18
ATE323695T1 (de) 2006-05-15
KR100822981B1 (ko) 2008-04-16
MXPA05000657A (es) 2005-08-19
NZ538221A (en) 2006-11-30
AU2003259154C1 (en) 2004-02-09
US20050143423A1 (en) 2005-06-30
JP2005536519A (ja) 2005-12-02
EP1556371A2 (en) 2005-07-27
CA2492718A1 (en) 2004-01-29
KR20050047078A (ko) 2005-05-19
RU2292342C2 (ru) 2007-01-27
DK1556371T3 (da) 2006-08-21
RU2005105564A (ru) 2005-10-10
AU2003259154A1 (en) 2004-02-09
PL375255A1 (en) 2005-11-28
WO2004009583A3 (en) 2004-03-18

Similar Documents

Publication Publication Date Title
IL166371A0 (en) Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
NO20025590D0 (no) Fenylglycin-derivater
AU2003255845A1 (en) Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents
EP2289894A3 (en) Pyrrolo-triazine compounds useful as kinase inhibitors
TNSN05254A1 (en) Derivatives of 2-acylamino-4-phenylthiazole, preparation method thereof and application of same in therapeutics
TW200642689A (en) Immunosuppressive agent and anti-tumor agent comprising heterocyclic compound as active ingredient
NO20062699L (no) Smelteblandingsdispergeringer
RS52315B (en) DIARYLMETHYL PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE
AP2000001900A0 (en) Halogeneted amidino amino acid derivatives useful as nitric oxide synthase inhibitors.
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
TW200733963A (en) Cough inhibitor
WO2005032490A3 (en) Cyclic diamines and derivatives as factor xa inhibitors
AP2002002466A0 (en) 3-heterocycliylpropanohydroxamic acid PCP INHIBITORS.
DE602004026107D1 (de) Intranasale zusammensetzungen
EE200300129A (et) Distamütsiini alfa-halogenoakrüloüülderivaadi kasutamine
TR200302134T4 (tr) 2-metil-tiazolidin-2,4-dikarboksilik asit ve/veya bunun fizyolojik olarak uygun tuzlarının anti-kanser ajanları olarak kullanımı.
DE60324703D1 (de) Barbitursäure derivaten.
TW200509921A (en) Alkaline salts
WO2004048381A3 (en) Pyrazoloazepine compounds as pharmaceutical agents
HK1070646A1 (en) Neurotensin active 2,3-diaryl-pyrazolidine derivatives
SG171472A1 (en) Substituted aniline derivatives
NO20054289D0 (no) Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorer
ATE491709T1 (de) Pyrrolidinohydrochinazoline
TW200510335A (en) Water-soluble phenylpyridazine derivatives and medicines containing the same
MXPA05009243A (es) N-aril-2-oxazolidinona-5-carboxamidas y sus derivados.