TW200502231A - Prodrugs of proton pump inhibitors - Google Patents

Prodrugs of proton pump inhibitors

Info

Publication number
TW200502231A
TW200502231A TW092131253A TW92131253A TW200502231A TW 200502231 A TW200502231 A TW 200502231A TW 092131253 A TW092131253 A TW 092131253A TW 92131253 A TW92131253 A TW 92131253A TW 200502231 A TW200502231 A TW 200502231A
Authority
TW
Taiwan
Prior art keywords
prodrugs
pump inhibitors
proton pump
proton
bioavailability
Prior art date
Application number
TW092131253A
Other languages
English (en)
Inventor
Michael Garst
George Sachs
Jai M Shin
Original Assignee
Winston Pharmaceuticals Llc
U S Government Represented By The Dept Of Veteran
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Winston Pharmaceuticals Llc, U S Government Represented By The Dept Of Veteran, Univ California filed Critical Winston Pharmaceuticals Llc
Publication of TW200502231A publication Critical patent/TW200502231A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
TW092131253A 2002-07-19 2003-11-07 Prodrugs of proton pump inhibitors TW200502231A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
US10/620,252 US6897227B2 (en) 2002-07-19 2003-07-15 Prodrugs of proton pump inhibitors

Publications (1)

Publication Number Publication Date
TW200502231A true TW200502231A (en) 2005-01-16

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092131253A TW200502231A (en) 2002-07-19 2003-11-07 Prodrugs of proton pump inhibitors

Country Status (23)

Country Link
US (3) US6897227B2 (zh)
EP (1) EP1556371B1 (zh)
JP (1) JP4463103B2 (zh)
KR (2) KR100822981B1 (zh)
AT (1) ATE323695T1 (zh)
AU (1) AU2003259154B2 (zh)
BR (1) BR0312802A (zh)
CA (1) CA2492718C (zh)
CO (1) CO5690576A2 (zh)
DE (1) DE60304726T2 (zh)
DK (1) DK1556371T3 (zh)
ES (1) ES2263028T3 (zh)
HK (1) HK1079207A1 (zh)
IL (1) IL166371A0 (zh)
MX (1) MXPA05000657A (zh)
NO (1) NO20050801L (zh)
NZ (1) NZ538221A (zh)
PL (1) PL375255A1 (zh)
PT (1) PT1556371E (zh)
RU (1) RU2292342C2 (zh)
TW (1) TW200502231A (zh)
WO (1) WO2004009583A2 (zh)
ZA (1) ZA200501116B (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
JP2007521314A (ja) * 2003-07-15 2007-08-02 アラーガン、インコーポレイテッド プロトンポンプ阻害薬の異性体純粋なプロドラッグを製造するための方法
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
AU2005216862A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
CA2559127A1 (en) * 2004-03-11 2005-09-29 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
DK1740571T3 (da) 2004-04-28 2009-11-02 Hetero Drugs Ltd Fremgangsmåde til fremstilling af pyridinylmethyl-1H-benzimidazolforbindelser i enantiomerisk beriget form eller som enkelte enantiomerer
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
US20070265311A1 (en) * 2006-01-10 2007-11-15 Rubino Mark P Therapeutic Salt Compositions and Methods
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
EP2193518A4 (en) * 2007-10-05 2010-10-27 Lg Electronics Inc PLASMA DISPLAY DEVICE
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
EP2627178B1 (en) 2010-10-11 2018-05-02 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
WO2012087861A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinoxalines and aza-quinoxalines as crth2 receptor modulators
WO2012087872A1 (en) 2010-12-23 2012-06-28 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
US20180021319A1 (en) * 2015-01-09 2018-01-25 The Regents Of The University Of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) * 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) * 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
DE69131627T2 (de) * 1990-06-20 2000-04-27 Astra Ab Soedertaelje Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
PL181801B1 (pl) * 1994-06-10 2001-09-28 Byk Gulden Lomberg Chem Fab Podstawione aryloalkilotioalkilotiopirydyny do zwalczania bakterii Helicobacter oraz srodek leczniczy zawierajacy podstawione aryloalkilotioalkilotiopirydyny PL
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
ID28273A (id) * 1998-08-10 2001-05-10 Partnership Of Michael E Garst Prodrug inhibitor pompa proton
EP1104415B1 (en) * 1998-08-12 2004-11-10 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) * 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
AU2001294228A1 (en) * 2000-10-12 2002-04-22 Takeda Chemical Industries Ltd. Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
KR100822981B1 (ko) 2008-04-16
WO2004009583A3 (en) 2004-03-18
WO2004009583A2 (en) 2004-01-29
US6897227B2 (en) 2005-05-24
PL375255A1 (en) 2005-11-28
CA2492718C (en) 2010-12-21
CO5690576A2 (es) 2006-10-31
DE60304726T2 (de) 2007-08-09
DK1556371T3 (da) 2006-08-21
ES2263028T3 (es) 2006-12-01
ATE323695T1 (de) 2006-05-15
RU2005105564A (ru) 2005-10-10
HK1079207A1 (en) 2006-03-31
JP2005536519A (ja) 2005-12-02
EP1556371B1 (en) 2006-04-19
AU2003259154B2 (en) 2006-12-07
JP4463103B2 (ja) 2010-05-12
CA2492718A1 (en) 2004-01-29
AU2003259154A1 (en) 2004-02-09
ZA200501116B (en) 2006-11-29
US20050143423A1 (en) 2005-06-30
EP1556371A2 (en) 2005-07-27
NZ538221A (en) 2006-11-30
KR20050047078A (ko) 2005-05-19
AU2003259154C1 (en) 2004-02-09
DE60304726D1 (de) 2006-05-24
MXPA05000657A (es) 2005-08-19
IL166371A0 (en) 2006-01-16
BR0312802A (pt) 2005-04-19
KR20070005029A (ko) 2007-01-09
RU2292342C2 (ru) 2007-01-27
KR100788778B1 (ko) 2007-12-27
PT1556371E (pt) 2006-09-29
US20050182101A1 (en) 2005-08-18
NO20050801L (no) 2005-02-15
US20040102484A1 (en) 2004-05-27

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