CO5690576A2 - Profarmacos de los inhibidores de bomba de protones - Google Patents

Profarmacos de los inhibidores de bomba de protones

Info

Publication number
CO5690576A2
CO5690576A2 CO05013468A CO05013468A CO5690576A2 CO 5690576 A2 CO5690576 A2 CO 5690576A2 CO 05013468 A CO05013468 A CO 05013468A CO 05013468 A CO05013468 A CO 05013468A CO 5690576 A2 CO5690576 A2 CO 5690576A2
Authority
CO
Colombia
Prior art keywords
formula
profarmacos
proton pump
pump inhibitors
group
Prior art date
Application number
CO05013468A
Other languages
English (en)
Inventor
Michael E Garst
Original Assignee
Wiston Pharmaceuticals Llc
Univ California
Us Dept Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wiston Pharmaceuticals Llc, Univ California, Us Dept Veterans Affairs filed Critical Wiston Pharmaceuticals Llc
Publication of CO5690576A2 publication Critical patent/CO5690576A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

1.- Un compuesto de la Fórmula 1, Fórmula 2, Fórmula 3, o de la Fórmula 4 o los isómeros de los compuestos de las Fórmulas 2 y 3 en donde los grupos OCH3, y HF2CO, respectivamente se enlazaron a la posición 6 del anillo de bencimidazol, y caracterizado porque R representa los grupos seleccionados de las Fórmulas (i) hasta la (viii); la línea punteada representa el enlace conectado al grupo R con el grupo SO2, Y es un grupo alquilo de cadena recta o cadena recta ramificada disubstituida de 1 a 8 carbonos, o Y es N; ...
CO05013468A 2002-07-19 2005-02-15 Profarmacos de los inhibidores de bomba de protones CO5690576A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19

Publications (1)

Publication Number Publication Date
CO5690576A2 true CO5690576A2 (es) 2006-10-31

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05013468A CO5690576A2 (es) 2002-07-19 2005-02-15 Profarmacos de los inhibidores de bomba de protones

Country Status (23)

Country Link
US (3) US6897227B2 (es)
EP (1) EP1556371B1 (es)
JP (1) JP4463103B2 (es)
KR (2) KR100822981B1 (es)
AT (1) ATE323695T1 (es)
AU (1) AU2003259154B2 (es)
BR (1) BR0312802A (es)
CA (1) CA2492718C (es)
CO (1) CO5690576A2 (es)
DE (1) DE60304726T2 (es)
DK (1) DK1556371T3 (es)
ES (1) ES2263028T3 (es)
HK (1) HK1079207A1 (es)
IL (1) IL166371A0 (es)
MX (1) MXPA05000657A (es)
NO (1) NO20050801L (es)
NZ (1) NZ538221A (es)
PL (1) PL375255A1 (es)
PT (1) PT1556371E (es)
RU (1) RU2292342C2 (es)
TW (1) TW200502231A (es)
WO (1) WO2004009583A2 (es)
ZA (1) ZA200501116B (es)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
CA2493618A1 (en) * 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
MXPA06000410A (es) * 2003-07-15 2006-03-17 Allergan Inc Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones.
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
JP2007523163A (ja) * 2004-02-18 2007-08-16 アラーガン、インコーポレイテッド プロトンポンプインヒビターのプロドラッグの投与のための方法および組成物
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
US20090048302A1 (en) * 2004-03-11 2009-02-19 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
EP1740571B1 (en) 2004-04-28 2009-07-29 Hetero Drugs Limited A process for preparing pyridinylmethyl-1h- benzimidazole compounds in enantiomerically enriched form or as single enantiomers
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
NZ572007A (en) * 2006-05-09 2010-12-24 Astrazeneca Ab Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
US20100113524A1 (en) * 2006-09-19 2010-05-06 Garst Michael E Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
MX2013007295A (es) 2010-12-23 2013-08-26 Merck Sharp & Dohme Quinoxalinas y aza-quinoxalinas como moduladores del receptor de crth2.
EP2661265B1 (en) 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as crth2 receptor modulators
CN107405338A (zh) * 2015-01-09 2017-11-28 加州大学评议会 用于治疗胃肠道感染的组合物和方法
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

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US430042A (en) * 1890-06-10 Valve
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
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Also Published As

Publication number Publication date
NO20050801L (no) 2005-02-15
US6897227B2 (en) 2005-05-24
CA2492718C (en) 2010-12-21
AU2003259154B2 (en) 2006-12-07
US20040102484A1 (en) 2004-05-27
PT1556371E (pt) 2006-09-29
WO2004009583A2 (en) 2004-01-29
EP1556371B1 (en) 2006-04-19
BR0312802A (pt) 2005-04-19
DE60304726T2 (de) 2007-08-09
KR100788778B1 (ko) 2007-12-27
IL166371A0 (en) 2006-01-16
DE60304726D1 (de) 2006-05-24
KR20070005029A (ko) 2007-01-09
ES2263028T3 (es) 2006-12-01
HK1079207A1 (en) 2006-03-31
ZA200501116B (en) 2006-11-29
JP4463103B2 (ja) 2010-05-12
US20050182101A1 (en) 2005-08-18
ATE323695T1 (de) 2006-05-15
KR100822981B1 (ko) 2008-04-16
MXPA05000657A (es) 2005-08-19
NZ538221A (en) 2006-11-30
TW200502231A (en) 2005-01-16
AU2003259154C1 (en) 2004-02-09
US20050143423A1 (en) 2005-06-30
JP2005536519A (ja) 2005-12-02
EP1556371A2 (en) 2005-07-27
CA2492718A1 (en) 2004-01-29
KR20050047078A (ko) 2005-05-19
RU2292342C2 (ru) 2007-01-27
DK1556371T3 (da) 2006-08-21
RU2005105564A (ru) 2005-10-10
AU2003259154A1 (en) 2004-02-09
PL375255A1 (en) 2005-11-28
WO2004009583A3 (en) 2004-03-18

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