AR051778A2 - Derivados del acido dimetilaminocrotonico y procesos para supreparacion - Google Patents

Derivados del acido dimetilaminocrotonico y procesos para supreparacion

Info

Publication number
AR051778A2
AR051778A2 ARP050104937A ARP050104937A AR051778A2 AR 051778 A2 AR051778 A2 AR 051778A2 AR P050104937 A ARP050104937 A AR P050104937A AR P050104937 A ARP050104937 A AR P050104937A AR 051778 A2 AR051778 A2 AR 051778A2
Authority
AR
Argentina
Prior art keywords
supreparation
derivatives
processes
dimethylaminocrotonic acid
dimethylaminocrotonic
Prior art date
Application number
ARP050104937A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR051778A2 publication Critical patent/AR051778A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • External Artificial Organs (AREA)
  • Quinoline Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto de formula (1) (CH3)2NCH2=(O)-OH o una sal HCl del mismo. Reivindicacion 2: El compuesto de acuerdo con la reivindicacion 1, donde el compuesto es la sal HCl del mismo.
ARP050104937A 2001-08-07 2005-11-25 Derivados del acido dimetilaminocrotonico y procesos para supreparacion AR051778A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31064601P 2001-08-07 2001-08-07

Publications (1)

Publication Number Publication Date
AR051778A2 true AR051778A2 (es) 2007-02-07

Family

ID=23203475

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP020102977A AR036250A1 (es) 2001-08-07 2002-08-06 Una combinacion antineoplasica, un producto que la comprende y el uso de dicha combinacion para la fabricacion de un medicamento para el tratamiento de un neoplasma en un mamifero
ARP050104937A AR051778A2 (es) 2001-08-07 2005-11-25 Derivados del acido dimetilaminocrotonico y procesos para supreparacion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP020102977A AR036250A1 (es) 2001-08-07 2002-08-06 Una combinacion antineoplasica, un producto que la comprende y el uso de dicha combinacion para la fabricacion de un medicamento para el tratamiento de un neoplasma en un mamifero

Country Status (27)

Country Link
US (4) US6617333B2 (es)
EP (2) EP1414438B1 (es)
JP (2) JP2005505549A (es)
KR (1) KR20040029406A (es)
CN (3) CN1326523C (es)
AR (2) AR036250A1 (es)
AT (1) ATE314069T1 (es)
AU (2) AU2002330994B2 (es)
BR (1) BR0211769A (es)
CA (1) CA2455126A1 (es)
CY (1) CY1104983T1 (es)
DE (1) DE60208385T2 (es)
DK (1) DK1414438T3 (es)
EA (2) EA006226B1 (es)
ES (1) ES2252512T3 (es)
HK (1) HK1061204A1 (es)
HU (1) HUP0401089A3 (es)
IL (2) IL159859A0 (es)
MX (1) MXPA04001118A (es)
NO (2) NO325503B1 (es)
NZ (3) NZ560845A (es)
PL (1) PL368303A1 (es)
SG (1) SG170612A1 (es)
TW (2) TWI305527B (es)
UA (1) UA77200C2 (es)
WO (1) WO2003020266A1 (es)
ZA (1) ZA200401801B (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304390B2 (en) * 1997-07-31 2012-11-06 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treatment for preventing or reducing tumor growth in the liver of patient
US20050124608A1 (en) * 2001-04-03 2005-06-09 Redmond H. P. Treatment of cancers
US20030027818A1 (en) * 2001-04-03 2003-02-06 Redmond H. Paul Treatment of cancers
US20060199811A1 (en) * 1997-07-31 2006-09-07 Pfirrmann Rolf W Method of treatment for preventing or reducing tumor growth in the liver of patient
US7892530B2 (en) * 1999-06-04 2011-02-22 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of tumor metastases and cancer
US8030301B2 (en) * 1999-06-04 2011-10-04 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Treatment of cancers with methylol-containing compounds and at least one electrolyte
US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
TWI286074B (en) 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
PT2269603E (pt) 2001-02-19 2015-09-09 Novartis Ag Tratamento de tumores da mama com um derivado de rapamicina em combinação com exemestano
TWI233359B (en) * 2001-04-06 2005-06-01 Wyeth Corp Pharmaceutical composition for treating neoplasm
TWI296196B (en) * 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
US20020198137A1 (en) * 2001-06-01 2002-12-26 Wyeth Antineoplastic combinations
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
US20040122048A1 (en) * 2002-10-11 2004-06-24 Wyeth Holdings Corporation Stabilized pharmaceutical composition containing basic excipients
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.
EP2517729A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
UA83484C2 (uk) * 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
US20040258662A1 (en) * 2003-04-22 2004-12-23 Wyeth Antineoplastic agents
AU2004266572A1 (en) * 2003-08-01 2005-03-03 Wyeth Holdings Corporation Use of combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer
AR046194A1 (es) 2003-11-04 2005-11-30 Mayo Foundation Metodo de tratamiento del linfoma de celulas del manto
AR046639A1 (es) * 2003-11-21 2005-12-14 Schering Corp Combinaciones terapeuticas de anticuerpo anti- igfr1
WO2005070393A2 (en) * 2004-01-08 2005-08-04 Wyeth Directly compressible pharmaceutical composition of the rapamycin ester cci-779
RU2006127414A (ru) * 2004-01-16 2008-02-27 Вайет (Us) Хинолиновые промежуточные соединения ингибиторов рецептора тирозинкиназы и их синтез
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
AR047988A1 (es) * 2004-03-11 2006-03-15 Wyeth Corp Combinaciones antineoplásicas de cci-779 y rituximab
EP1789391B1 (en) * 2004-07-23 2017-06-28 Endocyte, Inc. Bivalent linkers and conjugates thereof
EP1804779A1 (en) * 2004-10-28 2007-07-11 Wyeth Use of an mtor inhibitor in treatment of uterine leiomyoma
PL1848414T3 (pl) * 2005-02-03 2011-10-31 Wyeth Llc Sposób leczenia nowotworu opornego na gefitinib
CA2600675C (en) * 2005-03-07 2015-12-15 Robarts Research Institute Use of a combination of myxoma virus and rapamycin for therapeutic treatment
WO2006101845A2 (en) * 2005-03-16 2006-09-28 Endocyte, Inc. Synthesis and purification of pteroic acid and conjugates thereof
EP1883621A2 (en) * 2005-05-25 2008-02-06 Wyeth Methods of preparing 3-cyano-quinolines and intermediates made thereby
RU2007143161A (ru) * 2005-05-25 2009-07-10 Вайет (Us) Способы синтеза замещенных 3-цианохинов и их продуктов
JP2008542266A (ja) * 2005-05-25 2008-11-27 ワイス ６−アルキルアミノキノリン誘導体の合成方法
MX2007016542A (es) * 2005-06-24 2008-03-04 Wyeth Corp 4-anilino-3-quinolinocarbonitrilos para el tratamiento de cancer.
BRPI0613574A2 (pt) * 2005-07-01 2016-11-16 Wyeth Corp forma cristalina isolada de um composto, método para preparar um composto, e, composição farmacêutica
CN103893778A (zh) * 2005-08-19 2014-07-02 恩多塞特公司 多药物配体缀合物
JP2009504783A (ja) * 2005-08-19 2009-02-05 エンドサイト，インコーポレイテッド ビンカアルカロイド、類似体および誘導体のリガンド結合体
PE20070763A1 (es) * 2005-11-04 2007-08-08 Wyeth Corp COMBINACIONES ANTINEOPLASICAS DE UN INHIBIDOR DE mTOR, TRASTUZUMAB Y/O HKI-272
AU2013204788B2 (en) * 2005-11-04 2016-12-08 Wyeth Llc Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
AU2016259316B2 (en) * 2005-11-04 2018-09-06 Wyeth Llc Antineoplastic combinations with mTOR inhibitor, herceptin, and/or HKI-272
SI2275103T1 (sl) * 2005-11-21 2014-07-31 Novartis Ag mTor inhibitorji pri zdravljenju endokrinih tumorjev
DE102006011507A1 (de) * 2006-03-14 2007-09-20 Lts Lohmann Therapie-Systeme Ag Wirkstoffbeladene Nanopartikel auf Basis hydrophiler Proteine
US20080119463A1 (en) * 2006-11-16 2008-05-22 Wyeth 4-Anilino-3-quinolinecarbonitriles for the treatment of acute myelogenous leukemia (AML)
WO2008101231A2 (en) * 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
WO2008121467A2 (en) * 2007-02-28 2008-10-09 Dana-Farber Cancer Institute, Inc. Combination therapy for treating cancer
EP2139523B1 (en) * 2007-03-14 2014-10-22 Endocyte, Inc. Conjugates of folate and tubulysin for targeted drug delivery
TW200901989A (en) * 2007-04-10 2009-01-16 Wyeth Corp Anti-tumor activity of CCI-779 in papillary renal cell cancer
BRPI0812970A2 (pt) * 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
US20090076060A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched temsirolimus
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
AU2008316835B2 (en) 2007-10-25 2015-07-16 Endocyte, Inc. Tubulysins and processes for preparing
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
CN102202667A (zh) 2008-08-04 2011-09-28 惠氏有限责任公司 4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
EP2367535B1 (en) * 2008-12-02 2017-02-22 Biocompatibles Uk Ltd. Pancreatic tumour treatment
MX356593B (es) 2009-04-06 2018-06-05 Wyeth Llc Régimen de tratamiento que utiliza neratinib para cáncer de mama.
PL2621903T3 (pl) 2010-09-29 2017-08-31 Intervet International B.V. Związki n-heteroarylu
EP2621923B1 (en) 2010-09-29 2017-03-29 Intervet International B.V. N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
MX2015004757A (es) 2012-10-16 2015-07-17 Endocyte Inc Conjugados de suministro de farmacos que contienen aminoacidos no naturales y metodo para usarlos.
US10274503B2 (en) 2013-05-08 2019-04-30 Vegenics Pty Limited Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis
US9242965B2 (en) * 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CA3228632A1 (en) 2015-12-24 2017-06-29 Kyowa Kirin Co., Ltd. .alpha.,.beta.-unsaturated amide compound

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU415255A1 (ru) * 1972-03-20 1974-02-15 Т. А. Асонова, А. Я. Берлин, А. Б. Зезин, Е. Ф. Разводовский СПОСОБ ПОЛУЧЕНИЯ р-БЕТАИ1ЮВВПТВci)iia aiisn^pii
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4194050A (en) 1976-04-30 1980-03-18 Sumitomo Chemical Company, Limited Process for producing an enamide
US4195021A (en) 1977-10-26 1980-03-25 Eli Lilly And Company 1,3-Disubstituted 2-azetidinone antibitotics
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US5206018A (en) 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
US5066493A (en) * 1978-11-03 1991-11-19 American Home Products Corporation Rapamycin in treatment of tumors
US4885171A (en) 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US4401653A (en) 1981-03-09 1983-08-30 Ayerst, Mckenna & Harrison Inc. Combination of rapamycin and picibanil for the treatment of tumors
BE897134A (fr) 1983-06-24 1983-12-27 Solvay Dienes polysubstitues
US4478959A (en) 1983-09-29 1984-10-23 Air Products And Chemicals, Inc. Amino and amido divalent metal carboxylates useful as catalysts for polyurethane formulations
DE3347659A1 (de) 1983-12-31 1985-07-11 Bayer Ag, 5090 Leverkusen Neue lackloesungen auf der basis von hydantoingruppen enthaltenden polymeren
US4664825A (en) 1984-10-25 1987-05-12 The Lubrizol Corporation Sulfurized compositions and lubricants containing them
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
AU634871B2 (en) 1990-03-20 1993-03-04 Banyu Pharmaceutical Co., Ltd. Substituted amine derivatives having anti-hyperlipemia activity
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
DE69209183T2 (de) 1991-06-18 1996-08-08 American Home Prod Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen
ZA924953B (en) 1991-07-25 1993-04-28 Univ Louisville Res Found Method of treating ocular inflammation
CN1069492A (zh) * 1991-08-21 1993-03-03 山之内制药株式会社 4-酰胺基咪唑衍生物
US5286731A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
US5286730A (en) 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory disease
US5516781A (en) 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
US5288711A (en) 1992-04-28 1994-02-22 American Home Products Corporation Method of treating hyperproliferative vascular disease
US5352783A (en) 1993-06-09 1994-10-04 Merck & Co., Inc. Microbial transformation product having immunosuppressive activity
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5561138A (en) 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5547948A (en) 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
US5496832A (en) 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6664288B1 (en) * 1999-04-14 2003-12-16 Dana Farber Cancer Institute, Inc. Method and composition for the treatment of cancer
US6465448B1 (en) * 1999-08-13 2002-10-15 Case Western Reserve University Methoxyamine potentiation of temozolomide anti-cancer activity
US6277983B1 (en) 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
ES2228932T3 (es) 2000-08-11 2005-04-16 Wyeth Procedimiento de tratamiento del carcinoma positivo de estrogenos.
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CL2004000016A1 (es) 2003-01-21 2005-04-15 Wyeth Corp Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina.

Also Published As

Publication number Publication date
EA200400284A1 (ru) 2004-06-24
WO2003020266A1 (en) 2003-03-13
NZ560845A (en) 2008-09-26
DE60208385D1 (de) 2006-02-02
MXPA04001118A (es) 2004-05-20
CA2455126A1 (en) 2003-03-13
TWI300351B (en) 2008-09-01
ZA200401801B (en) 2005-06-06
EA200501251A1 (ru) 2008-12-30
AU2006233165A1 (en) 2006-11-09
NO20040558L (no) 2004-02-06
EP1414438B1 (en) 2005-12-28
USRE41253E1 (en) 2010-04-20
CN1538842A (zh) 2004-10-20
EP1671943A1 (en) 2006-06-21
IL159859A0 (en) 2004-06-20
US6617333B2 (en) 2003-09-09
AU2006233165B2 (en) 2009-12-24
HUP0401089A3 (en) 2007-12-28
TW200626526A (en) 2006-08-01
NO20073801L (no) 2004-02-06
HK1061204A1 (en) 2004-09-10
US20030050222A1 (en) 2003-03-13
BR0211769A (pt) 2004-07-27
ATE314069T1 (de) 2006-01-15
SG170612A1 (en) 2011-05-30
DE60208385T2 (de) 2006-08-03
CN100415753C (zh) 2008-09-03
CN1326523C (zh) 2007-07-18
HUP0401089A2 (hu) 2004-09-28
NZ542272A (en) 2007-12-21
NO325503B1 (no) 2008-05-26
CN101279983A (zh) 2008-10-08
KR20040029406A (ko) 2004-04-06
JP2010155845A (ja) 2010-07-15
NZ530847A (en) 2006-02-24
USRE40418E1 (en) 2008-07-01
CY1104983T1 (el) 2010-03-03
PL368303A1 (en) 2005-03-21
AR036250A1 (es) 2004-08-25
USRE41084E1 (en) 2010-01-19
ES2252512T3 (es) 2006-05-16
UA77200C2 (en) 2006-11-15
EA006226B1 (ru) 2005-10-27
EP1414438A1 (en) 2004-05-06
EA011098B1 (ru) 2008-12-30
IL159859A (en) 2009-12-24
TWI305527B (en) 2009-01-21
DK1414438T3 (da) 2006-03-27
CN1803806A (zh) 2006-07-19
AU2002330994B2 (en) 2007-10-04
JP2005505549A (ja) 2005-02-24

Similar Documents

Publication Publication Date Title
AR051778A2 (es) Derivados del acido dimetilaminocrotonico y procesos para supreparacion
NO2022019I1 (no) Eribulin eller et farmasøytisk akseptabelt salt derav - forlenget SPC
ATE297203T1 (de) Antithrombotische mitteln
RS52625B (en) FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
RS51444B (sr) JEDINJENJA KOJA SADRŽE LAKTAM I NJIHOVI DERIVATI KAO INHIBITORI FAKTORA Xa
NO950297D0 (no) Prolinamidderivater
ECSP044992A (es) Inhibidores de la alquín-aril fosfodiesterasa-4
CY1111481T1 (el) Υποκατεστημενα αρυλοκυκλοπροπυλακεταμιδια ως ενεργοποιητες γλυκοκινασης
HRP20090281T1 (en) 1,2,3,4-tetrasubstituted indole for the treatment of respiratory diseases
ATE326453T1 (de) Antithrombotische amide
RS50140B (sr) Postupak za dobijanje perkihinina i njegova upotreba
PT1307455E (pt) Inibidores de adesao celular mediada por (alfa)l (beta)2
MA27567A1 (fr) Perindopril
CL2008003324A1 (es) Formulacion farmaceutica liquida de liberacion inmediata que comprende una sal de adicion de acido de un compuesto derivado de azetidina sustituido y un diluyente o portador farmaceuticamente aceptable, util para el tratamiento o prevencion de trombosis.
ECSP045234A (es) PROCEDIMIENTO PARA LA FABRICACION DE DERIVADOS DE ACIDO MEVALONICO INHIBIDORES DE ß-HIDROXI-ß-METILGLUTARILO-CO-ENZIMA-A REDUCTASA
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
ATE368645T1 (de) Aminosäurederivate als hiv-protease-inhibitoren
DK1458393T3 (da) Substituerede diketopiperaziner som oxytocinantagonister
ECSP034561A (es) Derivados puente de piperazina
ES2169242T3 (es) 2-amino-benzoxazinonas para el tratamiento de infecciones virales.
EA200400214A1 (ru) Азитромицин в виде разовой дозы
DE60114640D1 (en) Antithrombosemittel
DK1204658T3 (da) Benzofurylpiperazin-serotoninagonister
GB0212410D0 (en) Organic compounds
DK1180094T3 (da) Kondenserede polycykliske aminosyrer som farmaceutiske midler

Legal Events

Date Code Title Description
FB Suspension of granting procedure