ATE305463T1 - Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten - Google Patents

Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten

Info

Publication number
ATE305463T1
ATE305463T1 AT02791192T AT02791192T ATE305463T1 AT E305463 T1 ATE305463 T1 AT E305463T1 AT 02791192 T AT02791192 T AT 02791192T AT 02791192 T AT02791192 T AT 02791192T AT E305463 T1 ATE305463 T1 AT E305463T1
Authority
AT
Austria
Prior art keywords
group
carbon atoms
bond
heteroaryl
radical
Prior art date
Application number
AT02791192T
Other languages
English (en)
Inventor
Robert M Burk
Mark Holoboski
Mari F Posner
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ATE305463T1 publication Critical patent/ATE305463T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
AT02791192T 2001-11-05 2002-10-25 Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten ATE305463T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33883801P 2001-11-05 2001-11-05
PCT/US2002/034301 WO2003040126A1 (en) 2001-11-05 2002-10-25 φ-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGS AS EP2-RECEPTOR AGONISTS

Publications (1)

Publication Number Publication Date
ATE305463T1 true ATE305463T1 (de) 2005-10-15

Family

ID=23326368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02791192T ATE305463T1 (de) 2001-11-05 2002-10-25 Omega-zykloalkyl 17-heteroaryl prostaglandin-e2- analoga als ep2-rezeptoragonisten

Country Status (13)

Country Link
US (4) US6710072B2 (de)
EP (1) EP1442033B1 (de)
KR (1) KR20050039733A (de)
CN (1) CN1617868A (de)
AT (1) ATE305463T1 (de)
BR (1) BR0213911A (de)
CA (1) CA2466517A1 (de)
DE (1) DE60206408T2 (de)
ES (1) ES2246419T3 (de)
HK (1) HK1066801A1 (de)
MX (1) MXPA04004164A (de)
NZ (1) NZ532519A (de)
WO (1) WO2003040126A1 (de)

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US6875787B2 (en) * 2003-02-11 2005-04-05 Allergan, Inc. 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure
GB0329620D0 (en) * 2003-12-22 2004-01-28 Pharmagene Lab Ltd EP2 receptor agonists
WO2005080367A1 (en) 2004-02-12 2005-09-01 Pharmagene Laboratories Limited Ep2 receptor agonists
US20060135609A1 (en) * 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US7091231B2 (en) 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
JP5060311B2 (ja) 2005-01-14 2012-10-31 アラーガン インコーポレイテッド 高眼圧症状を処置するための置換シクロペンタンまたはシクロペンタノン
WO2006098918A2 (en) * 2005-03-10 2006-09-21 Allergan, Inc. Substituted gamma lactams as therapeutic agents
ATE515263T1 (de) * 2005-05-06 2011-07-15 Allergan Inc Substituierte beta-lactame und deren verwendung in der medizin
US7674786B2 (en) * 2005-05-06 2010-03-09 Allergan, Inc. Therapeutic β-lactams
WO2007005176A1 (en) * 2005-06-29 2007-01-11 Allergan, Inc. Pyrrolidinones for the treatment of glaucoma and ocular hypertension
US8080567B2 (en) 2005-08-09 2011-12-20 Asterand Uk Limited EP2 receptor agonists
US7585895B2 (en) * 2005-12-06 2009-09-08 Allergan, Inc. Therapeutic substituted cyclopentanes
US7427685B2 (en) 2005-12-06 2008-09-23 Allergan, Inc. Therapeutic substituted cyclopentanes
US7592364B2 (en) * 2006-02-28 2009-09-22 Allergan, Inc. Substituted gamma lactams as therapeutic agents
EP1996546B1 (de) * 2006-03-20 2014-11-26 Allergan, Inc. Substituierte gamma-lactame als prostaglandin-ep4-agonisten
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
US7439372B2 (en) 2006-05-03 2008-10-21 Allergan, Inc. Therapeutic compounds
US20090016981A1 (en) 2006-05-03 2009-01-15 Allergan, Inc. Therapeutic compounds
DE602007013412D1 (de) * 2006-08-09 2011-05-05 Allergan Inc Therapeutische amide und entsprechende verbindungen
US7985767B2 (en) * 2006-09-06 2011-07-26 Allergan, Inc. Therapeutic amides
EP1903037A1 (de) * 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors
US8193373B2 (en) 2006-12-11 2012-06-05 Allergan, Inc. Therapeutic compounds
US20100011786A1 (en) * 2006-12-28 2010-01-21 Lg Electronics Inc. Ice making system and method for ice making of refrigerator
WO2008091810A1 (en) * 2007-01-22 2008-07-31 Allergan, Inc. Substituted arylcylopentenes as therapeutic agents
CA2675981A1 (en) * 2007-01-22 2008-07-31 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
BRPI0808377B8 (pt) * 2007-01-31 2021-05-25 Allergan Inc composto, composição e uso de um composto
US8063240B2 (en) 2007-11-14 2011-11-22 Cayman Chemical Company, Incorporated Prostaglandin E1 and E2 analogs for the treatment of various medical conditions
US8063033B2 (en) * 2008-01-18 2011-11-22 Allergan, Inc. Therapeutic beta-lactams
US7956051B2 (en) * 2008-01-24 2011-06-07 Allergan, Inc. Therapeutic amides and related compounds
US8633310B2 (en) * 2008-02-19 2014-01-21 Allergan, Inc. Therapeutic substituted lactams
US8202855B2 (en) 2008-03-04 2012-06-19 Allergan, Inc Substituted beta-lactams
WO2009111322A1 (en) * 2008-03-04 2009-09-11 Allergan, Inc. Substituted cyclopentanes having prostaglandin activity
US7964596B2 (en) * 2008-03-07 2011-06-21 Allergan, Inc. Therapeutic compounds
US20090233921A1 (en) * 2008-03-11 2009-09-17 Allergan, Inc. Therapeutic cyclopentane derivatives
US7960379B2 (en) * 2008-03-14 2011-06-14 Allergan, Inc. Therapeutic compounds
US7705001B2 (en) * 2008-03-18 2010-04-27 Allergan, Inc Therapeutic substituted gamma lactams
US8198318B2 (en) * 2008-03-18 2012-06-12 Allergen, Inc. Therapeutic amides
US7960378B2 (en) * 2008-03-18 2011-06-14 Allergan, Inc. Therapeutic compounds
US7732443B2 (en) * 2008-03-18 2010-06-08 Yariv Donde Therapeutic substituted cyclopentanes
US7956055B2 (en) * 2008-03-25 2011-06-07 Allergan, Inc. Substituted gamma lactams as therapeutic agents
WO2009132097A1 (en) 2008-04-24 2009-10-29 Allergan, Inc. Substituted gamma lactams as therapeutic agents
ES2735217T3 (es) * 2008-04-24 2019-12-17 Allergan Inc Arilciclopentenos sustituidos como agentes terapéuticos
US7713968B2 (en) * 2008-04-24 2010-05-11 Allergan, Inc. Substituted arylcyclopentenes as therapeutic agents
US7964634B2 (en) * 2008-04-24 2011-06-21 Allergan, Inc. Therapeutic compounds
US7737140B2 (en) * 2008-04-24 2010-06-15 Allergan, Inc. Therapeutic compounds
ES2399314T3 (es) 2008-04-24 2013-03-27 Allergan, Inc. Gamma lactamas sustituidas como agentes terapeúticos
EP2297084A1 (de) * 2008-04-24 2011-03-23 Allergan, Inc. Therapeutische verbindungen
AU2009239371B2 (en) 2008-04-24 2014-05-01 Allergan, Inc. Thiophene derivatives useful as ocular hypotensive agents
EP2303836A1 (de) * 2008-05-09 2011-04-06 Allergan, Inc. Therapeutische cyclopentanderivate
WO2009137412A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
EP2285790A1 (de) * 2008-05-09 2011-02-23 Allergan, Inc. Therapeutische verbindungen
WO2009137411A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic compounds
CA2723894A1 (en) 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic substituted hydantoins, and related compounds
AU2009244535A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic N-aryl or N-heteroaryl pyrazolidine and pyrazolidinone derivatives
US7786117B2 (en) * 2008-05-09 2010-08-31 Allergan, Inc. Therapeutic substituted thiazolidinones, oxazolidinones, and related compounds
CA2724271A1 (en) * 2008-05-15 2009-11-19 Allergan, Inc. Therapeutic substituted cyclopentanes
WO2009146255A1 (en) 2008-05-27 2009-12-03 Allergan, Inc. Prostaglandin produgs as hypotensive agents
WO2009142969A1 (en) * 2008-05-20 2009-11-26 Allergan, Inc. Therapeutic lactams
US7985765B2 (en) * 2008-08-20 2011-07-26 Allergan, Inc. Therapeutic substituted pyrroles
US20110293549A1 (en) 2009-02-03 2011-12-01 Athena Cosmetics, Inc. Composition, method and kit for enhancing hair
BR112016006951B1 (pt) 2013-09-30 2022-10-04 Patheon Api Services Inc Novas vias de síntese para prostaglandinas e intermediários de prostaglandina com o uso de metátese
US10105488B2 (en) 2013-12-12 2018-10-23 Medtronic Minimed, Inc. Predictive infusion device operations and related methods and systems

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US5028624A (en) * 1989-07-27 1991-07-02 Allergan, Inc. Intraocular pressure reducing 9,15-diacyl prostaglandins
US4994274A (en) * 1989-07-27 1991-02-19 Allergan, Inc. Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using
US5034413A (en) * 1989-07-27 1991-07-23 Allergan, Inc. Intraocular pressure reducing 9,11-diacyl prostaglandins
CA2021316C (en) * 1989-07-27 2000-10-24 Ming Fai Chan Intraocular pressure reducing 11-acyl prostaglandins
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Also Published As

Publication number Publication date
EP1442033A1 (de) 2004-08-04
US7223746B2 (en) 2007-05-29
ES2246419T3 (es) 2006-02-16
CA2466517A1 (en) 2003-05-15
US7514462B2 (en) 2009-04-07
KR20050039733A (ko) 2005-04-29
DE60206408D1 (de) 2006-02-09
US20030130239A1 (en) 2003-07-10
CN1617868A (zh) 2005-05-18
EP1442033B1 (de) 2005-09-28
BR0213911A (pt) 2004-09-28
HK1066801A1 (en) 2005-04-01
NZ532519A (en) 2006-11-30
WO2003040126A1 (en) 2003-05-15
DE60206408T2 (de) 2006-06-22
US20070219262A1 (en) 2007-09-20
US20050113338A1 (en) 2005-05-26
US6710072B2 (en) 2004-03-23
US7022726B2 (en) 2006-04-04
US20040106580A1 (en) 2004-06-03
MXPA04004164A (es) 2004-09-06

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