YU47481B - Derivati beta-laktama i postupak za njihovo dobijanje - Google Patents

Derivati beta-laktama i postupak za njihovo dobijanje

Info

Publication number
YU47481B
YU47481B YU74489A YU74489A YU47481B YU 47481 B YU47481 B YU 47481B YU 74489 A YU74489 A YU 74489A YU 74489 A YU74489 A YU 74489A YU 47481 B YU47481 B YU 47481B
Authority
YU
Yugoslavia
Prior art keywords
derivatives
lactames
beta
procedure
obtaining
Prior art date
Application number
YU74489A
Other languages
English (en)
Other versions
YU74489A (en
Inventor
P. Bissolino
M. Alpegiani
E. Perrone
P. Orezzi
G. Cassinelli
G. Franceschi
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of YU74489A publication Critical patent/YU74489A/xx
Publication of YU47481B publication Critical patent/YU47481B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Derivati beta-laktama formule (Ia) ili (b): gde A predstavlja atom vodonika, C1-C6 alkil, C2-C6 alkenil, benzil ili u datom primeru supstituisanu fenilnu grupu, pri čemu su supstituenti C1-C4 alkilne grupe; R1 predstavlja hloro, bromo ili C1-C4 alkoksi grupu; R2 i R3 su atomi vodonika; R4 je 5- ili 6-član heterocikliltiometil grupa, koja sadrži 1 do 4 atoma azota i/ili atom sumpora i u datom primeru je supstituisana s okso, hidroksi ili C1-C4 alkilnim grupama ili u datom primeru supstituisanom C1-C4 alkilnom grupom, pri čemu su supstituenti atomi halogena ili C1-C4 alkil karboniloksi grupa. Prijava sadrži još 1 nezavisan zahtev.
YU74489A 1988-04-13 1989-04-12 Derivati beta-laktama i postupak za njihovo dobijanje YU47481B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888808701A GB8808701D0 (en) 1988-04-13 1988-04-13 Beta-lactam derivatives

Publications (2)

Publication Number Publication Date
YU74489A YU74489A (en) 1991-02-28
YU47481B true YU47481B (sh) 1995-10-03

Family

ID=10635113

Family Applications (1)

Application Number Title Priority Date Filing Date
YU74489A YU47481B (sh) 1988-04-13 1989-04-12 Derivati beta-laktama i postupak za njihovo dobijanje

Country Status (23)

Country Link
US (1) US5077286A (sh)
EP (1) EP0337704B1 (sh)
JP (1) JP2840286B2 (sh)
KR (1) KR0138771B1 (sh)
CN (1) CN1037151A (sh)
AT (1) ATE123778T1 (sh)
AU (1) AU615048B2 (sh)
CA (1) CA1325077C (sh)
DE (1) DE68923033T2 (sh)
DK (1) DK175689A (sh)
ES (1) ES2075850T3 (sh)
FI (1) FI93731C (sh)
GB (1) GB8808701D0 (sh)
GR (1) GR3017081T3 (sh)
HU (1) HU206118B (sh)
IE (1) IE67549B1 (sh)
IL (1) IL89929A0 (sh)
MY (1) MY104428A (sh)
NO (1) NO173016C (sh)
NZ (1) NZ228681A (sh)
SU (2) SU1750430A3 (sh)
YU (1) YU47481B (sh)
ZA (1) ZA892629B (sh)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132301A (en) * 1983-05-02 1992-07-21 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
AU661453B2 (en) * 1989-10-06 1995-07-27 Synphar Laboratories, Inc. Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
GB8928373D0 (en) * 1989-12-15 1990-02-21 Erba Carlo Spa Beta-lactam derivatives
GB9011463D0 (en) * 1990-05-22 1990-07-11 Erba Carlo Spa Process for the preparation of 7 alpha-alkoxycephem derivatives
US5162348A (en) * 1990-05-24 1992-11-10 Imperial Chemical Industries Plc Treatment of cystic fibrosis
DE69129083T2 (de) * 1990-05-24 1998-07-09 Zeneca Ltd Therapeutisches Mittel zur Vorbeugung und Behandlung des Atemnotsyndroms bei Erwachsenen
EP0458537B1 (en) * 1990-05-24 1999-03-31 Zeneca Limited Use of a therapeutic compound for the treatment of bronchitis
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5446037A (en) * 1991-12-05 1995-08-29 Synphar Laboratories, Inc. 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
DE69331089T2 (de) * 1992-02-18 2002-07-18 Otsuka Kagaku K.K., Osaka Beta-Laktam und Cepham Verbindungen und Ihre Herstellung
GB9207715D0 (en) * 1992-04-08 1992-05-27 Erba Carlo Spa 2,2-disubstituted cephem sulphones
WO1993024493A1 (fr) * 1992-05-27 1993-12-09 Teijin Limited Derive de cephalosporine
GB2273097B (en) * 1992-12-04 1996-09-18 Erba Carlo Spa 4-Alkyl and 4-alkenyl delta-3-cephem sulphone human leukocyte elastase inhibitors
AU685433B2 (en) 1993-02-12 1998-01-22 Regents Of The University Of Minnesota Pulmonary administration of sCR1 and other complement inhibitory proteins
GB9304440D0 (en) * 1993-03-04 1993-04-21 Erba Carlo Spa 2-acyloxycephem derivatives
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5629306A (en) 1994-12-09 1997-05-13 Research Corporation Technologies, Inc. 7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) * 1994-12-09 1997-01-28 Southern Methodist University 7-vinylidene cephalosporins and methods of using the same
GB9513818D0 (en) * 1995-07-06 1995-09-06 Pharmacia Spa 7,7-Disubstituted cephem-4-ketones
US5760027A (en) * 1996-12-06 1998-06-02 Research Corporation Technologies, Inc. Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
AU2004268593B2 (en) * 2003-08-25 2012-02-02 Revaax Pharmaceuticals, Llc Oral neurotherapeutic cefazolin compositions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799922A (en) * 1971-11-17 1974-03-26 Smithkline Corp 4-substituted 3-cephem compounds
IN149747B (sh) * 1977-06-07 1982-04-03 Pfizer
NZ190797A (en) * 1978-06-06 1982-08-17 Pfizer Combination of penicillanic 1,1-dioxide and 7-(d-2-(4-ethylpiperazin-2 3-dione-1-carboxamido)-2-(4-hydroxphenyl)acetamido)-3-(1-methyl-5-tetrazolyl)-thiomethyl-3-desacetoxymethylcephalosporanic acid
NZ193020A (en) * 1979-03-05 1982-11-23 Pfizer Preparation of penicillanic acid 1,1-dioxide and intermediates therefor
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4381263A (en) * 1981-03-23 1983-04-26 Pfizer Inc. Process for the preparation of penicillanic acid esters
IN159362B (sh) * 1981-03-23 1987-05-09 Pfizer
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4637999A (en) * 1983-05-02 1987-01-20 Merck & Co., Inc. Substituted cephalosporins as anti-inflammatory and antidegenerative agents
EP0124081A3 (en) * 1983-05-02 1986-11-26 Merck & Co. Inc. New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them
US4468351A (en) * 1983-06-06 1984-08-28 Pfizer Inc. Process for debromination of dibromopenicillanic acid and derivatives
JPS62284386A (ja) * 1986-06-03 1987-12-10 日立電子エンジニアリング株式会社 プロ−ビング方式
EP0267723B1 (en) * 1986-11-12 1996-02-07 Merck & Co. Inc. New substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents

Also Published As

Publication number Publication date
GB8808701D0 (en) 1988-05-18
SU1750430A3 (ru) 1992-07-23
JP2840286B2 (ja) 1998-12-24
IE891132L (en) 1989-10-13
YU74489A (en) 1991-02-28
HUT50348A (en) 1990-01-29
DK175689A (da) 1989-10-14
DE68923033T2 (de) 1995-10-26
NZ228681A (en) 1991-07-26
NO173016C (no) 1993-10-13
AU3276289A (en) 1989-10-19
EP0337704A3 (en) 1991-09-25
HU206118B (en) 1992-08-28
CA1325077C (en) 1993-12-07
FI93731B (fi) 1995-02-15
KR0138771B1 (ko) 1998-05-15
EP0337704B1 (en) 1995-06-14
DE68923033D1 (de) 1995-07-20
MY104428A (en) 1994-03-31
FI891700A0 (fi) 1989-04-11
NO891516L (no) 1989-10-16
IL89929A0 (en) 1989-12-15
AU615048B2 (en) 1991-09-19
FI93731C (fi) 1995-05-26
US5077286A (en) 1991-12-31
KR890016048A (ko) 1989-11-28
IE67549B1 (en) 1996-04-17
EP0337704A2 (en) 1989-10-18
ZA892629B (en) 1989-12-27
FI891700A (fi) 1989-10-14
ES2075850T3 (es) 1995-10-16
GR3017081T3 (en) 1995-11-30
ATE123778T1 (de) 1995-06-15
DK175689D0 (da) 1989-04-12
NO891516D0 (no) 1989-04-12
SU1766261A3 (ru) 1992-09-30
CN1037151A (zh) 1989-11-15
JPH0228183A (ja) 1990-01-30
NO173016B (no) 1993-07-05

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