NO955023L - Piperidinderivater og fremgangsmåte for fremstilling derav - Google Patents

Piperidinderivater og fremgangsmåte for fremstilling derav

Info

Publication number
NO955023L
NO955023L NO955023A NO955023A NO955023L NO 955023 L NO955023 L NO 955023L NO 955023 A NO955023 A NO 955023A NO 955023 A NO955023 A NO 955023A NO 955023 L NO955023 L NO 955023L
Authority
NO
Norway
Prior art keywords
preparation
piperidine derivatives
alkyl
compounds
coor4
Prior art date
Application number
NO955023A
Other languages
English (en)
Other versions
NO955023D0 (no
NO308599B1 (no
Inventor
Ambra Thomas Edward D
Original Assignee
Albany Molecular Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22176189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO955023(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Albany Molecular Res Inc filed Critical Albany Molecular Res Inc
Publication of NO955023L publication Critical patent/NO955023L/no
Publication of NO955023D0 publication Critical patent/NO955023D0/no
Publication of NO308599B1 publication Critical patent/NO308599B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO19955023A 1993-06-24 1995-12-12 Piperidinderivater og fremgangsmate for fremstilling derav NO308599B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8310293A 1993-06-24 1993-06-24
PCT/US1994/006873 WO1995000482A1 (en) 1993-06-24 1994-06-21 Piperidine derivatives and process for their production

Publications (3)

Publication Number Publication Date
NO955023L true NO955023L (no) 1995-12-12
NO955023D0 NO955023D0 (no) 1995-12-12
NO308599B1 NO308599B1 (no) 2000-10-02

Family

ID=22176189

Family Applications (2)

Application Number Title Priority Date Filing Date
NO19955023A NO308599B1 (no) 1993-06-24 1995-12-12 Piperidinderivater og fremgangsmate for fremstilling derav
NO994582A NO994582D0 (no) 1993-06-24 1999-09-21 Fremgangsmaate for fremstilling av piperidinderivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO994582A NO994582D0 (no) 1993-06-24 1999-09-21 Fremgangsmaate for fremstilling av piperidinderivater

Country Status (16)

Country Link
US (9) US5589487A (no)
EP (4) EP1369409B1 (no)
JP (4) JP3034047B2 (no)
KR (2) KR100387347B1 (no)
AT (3) ATE254594T1 (no)
AU (1) AU670004B2 (no)
CA (1) CA2147126C (no)
DE (3) DE69433346T2 (no)
DK (3) DK0703902T3 (no)
ES (3) ES2129130T3 (no)
FI (1) FI109691B (no)
HU (1) HU226559B1 (no)
NO (2) NO308599B1 (no)
NZ (1) NZ268513A (no)
PT (2) PT1026147E (no)
WO (1) WO1995000482A1 (no)

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PT1214937E (pt) * 1992-08-03 2007-07-25 Sepracor Inc Carboxilato de terfenadina e o tratamento de irritação dérmica.
DK0703902T3 (da) * 1993-06-24 1999-08-23 Albany Molecular Res Inc Fremgangsmåde til fremstilling af piperidinderivater
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DE69431954T2 (de) 1993-06-25 2003-11-06 Merrell Pharmaceuticals Inc., Cincinnati Neue zwischenprodukte für die herstellung von antihistaminschen 4-diphenylmethyl/diphenylmethoxypiperidin-derivaten
ATE220667T1 (de) * 1994-05-18 2002-08-15 Aventis Pharma Inc Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
NZ302926A (en) * 1995-02-28 1998-10-28 Hoechst Marion Roussel Inc Composition for use as antihistamines comprising piperidinoalkanol derivatives and inert ingredients
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
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CN102070512B (zh) * 2009-11-21 2014-11-19 浙江华海药业股份有限公司 一种高纯度非索非那定及其中间体的合成路线与制备方法
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ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
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PT1214937E (pt) * 1992-08-03 2007-07-25 Sepracor Inc Carboxilato de terfenadina e o tratamento de irritação dérmica.
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DK0703902T3 (da) * 1993-06-24 1999-08-23 Albany Molecular Res Inc Fremgangsmåde til fremstilling af piperidinderivater
DE69431954T2 (de) * 1993-06-25 2003-11-06 Merrell Pharmaceuticals Inc., Cincinnati Neue zwischenprodukte für die herstellung von antihistaminschen 4-diphenylmethyl/diphenylmethoxypiperidin-derivaten
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Also Published As

Publication number Publication date
US5589487A (en) 1996-12-31
JPH11236373A (ja) 1999-08-31
US5578610A (en) 1996-11-26
WO1995000482A1 (en) 1995-01-05
EP0703902A4 (no) 1996-04-10
DK1369409T3 (da) 2006-08-14
JPH08511806A (ja) 1996-12-10
FI956270A0 (fi) 1995-12-27
DE69434696T2 (de) 2006-11-16
CA2147126A1 (en) 1995-01-05
AU7174894A (en) 1995-01-17
US5750703A (en) 1998-05-12
DE69434696D1 (de) 2006-05-18
DE69433346T2 (de) 2004-09-09
US5581011A (en) 1996-12-03
PT1026147E (pt) 2004-04-30
DE69415319D1 (de) 1999-01-28
DE69415319T2 (de) 1999-06-10
NZ268513A (en) 1996-09-25
HU9503719D0 (en) 1996-02-28
KR100387348B1 (ko) 2003-06-12
NO994582L (no) 1995-12-12
PT1369409E (pt) 2006-08-31
JP3658291B2 (ja) 2005-06-08
HU226559B1 (en) 2009-03-30
NO955023D0 (no) 1995-12-12
EP1369409A1 (en) 2003-12-10
EP0703902B1 (en) 1998-12-16
EP1369409B1 (en) 2006-04-05
ATE174589T1 (de) 1999-01-15
JP2001031650A (ja) 2001-02-06
ATE322473T1 (de) 2006-04-15
JP2002212166A (ja) 2002-07-31
EP0703902A1 (en) 1996-04-03
AU670004B2 (en) 1996-06-27
EP1026147B1 (en) 2003-11-19
DK0703902T3 (da) 1999-08-23
US20060241303A1 (en) 2006-10-26
ES2211444T3 (es) 2004-07-16
US20060052610A1 (en) 2006-03-09
US7238834B2 (en) 2007-07-03
ATE254594T1 (de) 2003-12-15
DE69433346D1 (de) 2003-12-24
JP3195297B2 (ja) 2001-08-06
KR960703398A (ko) 1996-08-17
ES2261871T3 (es) 2006-11-16
NO308599B1 (no) 2000-10-02
KR100387347B1 (ko) 2003-11-28
US7390906B2 (en) 2008-06-24
ES2129130T3 (es) 1999-06-01
DK1026147T3 (da) 2004-03-22
US5994549A (en) 1999-11-30
FI109691B (fi) 2002-09-30
CA2147126C (en) 1999-08-24
EP1026147A1 (en) 2000-08-09
JP3034047B2 (ja) 2000-04-17
NO994582D0 (no) 1999-09-21
US5663412A (en) 1997-09-02
HUT73235A (en) 1996-07-29
FI956270L (fi) 1995-12-27
JP4124998B2 (ja) 2008-07-23
US20080227983A1 (en) 2008-09-18
EP0723958A1 (en) 1996-07-31

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