ECSP088367A - Derivados de bifenilo y su uso en el tratamiento de la hepatitis c - Google Patents
Derivados de bifenilo y su uso en el tratamiento de la hepatitis cInfo
- Publication number
- ECSP088367A ECSP088367A EC2008008367A ECSP088367A ECSP088367A EC SP088367 A ECSP088367 A EC SP088367A EC 2008008367 A EC2008008367 A EC 2008008367A EC SP088367 A ECSP088367 A EC SP088367A EC SP088367 A ECSP088367 A EC SP088367A
- Authority
- EC
- Ecuador
- Prior art keywords
- hepatitis
- treatment
- bifenyl
- derivatives
- variables
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto que es un derivado de bifenilo de la fórmula (I) o una sal farmacéuticamente aceptable del mismo, en donde: R1 es un grupo alquilo C1-C6 o una mitad -A1, -L1-A1, -A1-A1/, -L1-A1-A1/, -A1-L1-A1/, -A1-Y1-A1/, -A1-Het1-A1/, -L1-A1-Y1-A1/, -L1-A1-Het1-A1/, -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1/, -A1-Y1-Het1-A1/, -A1-Het1-Y1-A1/, -A1-Het1-L1-A1/, -A1-L1-Het1-A1/ o -L1-Het1-L1/; - A y B son iguales o diferentes y cada uno representa un enlace directo o una mitad -CO-NR/-, -NR/-CO-, -NR/-CO2-, -CO-, -NR/-CO-NR//-, -NR/-S(O)2-, -S(O)2-NR/-, -SO2-, -NR/-, -NR/-CO-CO-, -CO-O-, -O-CO-, -(alquileno C1-C2)-NR/- o -(hidroxialquileno C1-C2)-NR/-, en donde R/ y R// son iguales o diferentes y cada uno representa hidrógeno o alquilo C1-C4; - R2 y R3 son iguales o diferentes y cada uno representa alquilo C1-C4, alcoxi C1-C4, haloalquilo C1-C4, haloalcoxi C1-C4 o halógeno; n y m son iguales o diferentes y cada uno representa 0 ó 1; R4 es un grupo alquilo C1-C6 o una mitad -A4, -L4-A4, -A4-A4/, -L4-A4-A4/, -A4-L4-A4/, -A4-Y4-A4/, -A4-Het4-A4/, -L4-A4-Y4-A4/, -L4-A4-Het4-A4/, -L4-Het4-A4, -L4-Y4-A4, -L4-Y4-Het4-A4, -L4-Het4-Y4-A4, -L4-Y4-Het4-L4/, -A4-Y4-Het4-A4/, -A4-Het4-Y4-A4/, -A4-Het4-L4-A4/, -A4-L4-Het4-A4/ o -L4-Het4-L4/, cada A1, A4, A1/ y A4/ son iguales o diferentes y representan una mitad fenilo, heteroarilo de 5 a 10 miembros, heterocicliclo de 5 a 10 miembros o carbociclilo C3-C8; cada L1 y L4 son iguales o diferentes y representan un grupo alquileno C1-C4 o hidroxialquileno C1-C4; cada Y1 y Y4 son iguales o diferentes y representan -CO-, -SO- o -S(O)2-; cada L1/ y L4/ son iguales o diferentes y representan hidrógeno o un grupo alquilo C1-C4; y cada Het1 y Het4 son iguales o diferentes y representan -O-, -S- o -NR/-, en donde R/ es hidrógeno o un grupo alquilo C1-C4, estando las mitades fenilo, heteroarilo, heterociclilo y carbociclilo en R1 y R4 opcionalmente fusionadas a un anillo fenilo, heteroarilo de 5 a 10 miembros o heterociclilo de 5 a 10 miembros; y estando las mitades fenilo, heteroarilo, heterociclilo y carbociclilo en R1 y R4 no sustituidas o sustituidas por (a) un solo sustituyente no sustituido seleccionado entre -(alquilo C1-C4)-X1, -CO2R/, -SO2NR/R//, -S(O)2-R/, -CONR/R//, -NR/-CO-R///, -NR/-S(O)2-R///, -CO-NR/-(alquilo C1-C4)-NR/R// y -CO-O-(alquilo C1-C4)-NR/R// y/o (b) 1, 2 ó 3 sustituyentes no sustituidos seleccionados entre -(alquilo C1-C4)-X2, halógeno, alquilo C1-C4, alcoxi C1-C4, haloalquilo C1-C4, haloalcoxi C1-C4, hidroxialquilo C1-C4, hidroxi, ciano, nitro y -NR/R//, en donde X1 es -CO2R/, -SO2-R/, -NR/-CO2-R//, -NR/-S(O)2-R///, -CONR/R// o -SO2-NR/R//, cada X2 es igual o diferente y es ciano, nitro o -NR/R//, cada R/ y R// son iguales o diferentes y representan hidrógeno o alquilo C1-C4 y cada R/// es igual o diferente y representa alquilo C1-C4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0518971.7A GB0518971D0 (en) | 2005-09-16 | 2005-09-16 | Chemical compounds |
GB0610664A GB0610664D0 (en) | 2006-05-30 | 2006-05-30 | Chemical compounds |
GB0610663A GB0610663D0 (en) | 2006-05-30 | 2006-05-30 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP088367A true ECSP088367A (es) | 2008-06-30 |
Family
ID=37398704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2008008367A ECSP088367A (es) | 2005-09-16 | 2008-04-14 | Derivados de bifenilo y su uso en el tratamiento de la hepatitis c |
Country Status (23)
Country | Link |
---|---|
US (1) | US8008303B2 (es) |
EP (1) | EP1940786B1 (es) |
JP (1) | JP2009508835A (es) |
KR (1) | KR20080050490A (es) |
AT (1) | ATE478044T1 (es) |
AU (2) | AU2006290442B2 (es) |
BR (1) | BRPI0615934A2 (es) |
CA (1) | CA2621364A1 (es) |
CY (1) | CY1110835T1 (es) |
DE (1) | DE602006016313D1 (es) |
DK (1) | DK1940786T3 (es) |
EC (1) | ECSP088367A (es) |
ES (1) | ES2348332T3 (es) |
HK (1) | HK1121440A1 (es) |
HR (1) | HRP20100542T1 (es) |
IL (1) | IL189694A0 (es) |
NO (1) | NO20081846L (es) |
NZ (1) | NZ566276A (es) |
PL (1) | PL1940786T3 (es) |
PT (1) | PT1940786E (es) |
RS (1) | RS51470B (es) |
SI (1) | SI1940786T1 (es) |
WO (1) | WO2007031791A1 (es) |
Families Citing this family (90)
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UA93548C2 (uk) * | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Сполуки та композиції як модулятори хеджхогівського сигнального шляху |
CN102516115B (zh) | 2006-08-09 | 2016-05-11 | 史密丝克莱恩比彻姆公司 | 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物 |
US7759495B2 (en) | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7745636B2 (en) | 2006-08-11 | 2010-06-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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- 2006-09-18 PT PT06779478T patent/PT1940786E/pt unknown
- 2006-09-18 RS RSP-2010/0437A patent/RS51470B/en unknown
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- 2006-09-18 DE DE602006016313T patent/DE602006016313D1/de active Active
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- 2006-09-18 SI SI200630798T patent/SI1940786T1/sl unknown
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- 2006-09-18 AT AT06779478T patent/ATE478044T1/de active
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- 2006-09-18 PL PL06779478T patent/PL1940786T3/pl unknown
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HK1121440A1 (en) | 2009-04-24 |
NZ566276A (en) | 2011-03-31 |
AU2010238549A1 (en) | 2010-11-18 |
SI1940786T1 (sl) | 2010-11-30 |
CA2621364A1 (en) | 2007-03-22 |
EP1940786A1 (en) | 2008-07-09 |
CY1110835T1 (el) | 2015-06-10 |
PL1940786T3 (pl) | 2010-12-31 |
DE602006016313D1 (de) | 2010-09-30 |
ATE478044T1 (de) | 2010-09-15 |
AU2006290442B2 (en) | 2010-07-29 |
KR20080050490A (ko) | 2008-06-05 |
US8008303B2 (en) | 2011-08-30 |
PT1940786E (pt) | 2010-10-04 |
NO20081846L (no) | 2008-06-04 |
RS51470B (en) | 2011-04-30 |
EP1940786B1 (en) | 2010-08-18 |
JP2009508835A (ja) | 2009-03-05 |
DK1940786T3 (da) | 2010-11-08 |
US20080255105A1 (en) | 2008-10-16 |
BRPI0615934A2 (pt) | 2011-05-31 |
IL189694A0 (en) | 2008-06-05 |
HRP20100542T1 (hr) | 2010-11-30 |
AU2006290442A1 (en) | 2007-03-22 |
ES2348332T3 (es) | 2010-12-02 |
WO2007031791A1 (en) | 2007-03-22 |
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