PE20060574A1 - Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs) - Google Patents
Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs)Info
- Publication number
- PE20060574A1 PE20060574A1 PE2005000873A PE2005000873A PE20060574A1 PE 20060574 A1 PE20060574 A1 PE 20060574A1 PE 2005000873 A PE2005000873 A PE 2005000873A PE 2005000873 A PE2005000873 A PE 2005000873A PE 20060574 A1 PE20060574 A1 PE 20060574A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- growth hormone
- ghs
- phenyl
- agonists
- Prior art date
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
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- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
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- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
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- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ARILPIPERAZINA SULFONAMIDA DE FORMULA (I), EN DONDE Ra ES ARILO O HETEROARILO, TAL COMO FENILO, TIENILO, NAFTILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; Y ES UN ENLACE SENCILLO, CH2, CH2CH2 O CH=CH; Rb ES H O ALQUILO(C1-C6), Rc ES H O METILO; Rd ES ALQUILO(C1-C6); Re ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), COALQUILO(C1-C6), ALCOXI(C1-C6), HALOGENO, OH, TRIFLUOROMETILO O CIANO Y Rf ES H, ALQUILO(C1-C6), CICLOALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS. SON PREFERIDOS: N-[3-(CIS-3,5-DIMETIL-1-PIPERAZINIL)-4-(METILOXI)FENIL]-5-(2-PIRIDINIL)-2-TIENOSULFONAMIDA, 4-[(3-CLORO-2-CIANOFENIL)OXI]-N-[3-(CIS-3,5-DIMETIL-1-PIPERAZINIL)-4-(METILOXI)FENIL]BENCENOSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCESO DE ELABORACION. ESTOS COMPUESTOS SON AGONISTAS SELECTIVOS DE LOS SECRETAGOGOS DE LA HORMONA DE CRECIMIENTO (GHS) Y SON UTILES EN EL TRATAMIENTO DE CAQUEXIA, SARCOPENIA, OSTEOPOROSIS, ARTRITIS, DEFICIENCIA DE LA HORMONA DE CRECIMIENTO, TRANSTORNOS METABOLICOS, DE SUENO E INSUFICIENCIA CARDIACA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0416844A GB0416844D0 (en) | 2004-07-28 | 2004-07-28 | Novel compounds |
GB0514029A GB0514029D0 (en) | 2005-07-08 | 2005-07-08 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
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PE20060574A1 true PE20060574A1 (es) | 2006-06-24 |
Family
ID=34972973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PE2005000873A PE20060574A1 (es) | 2004-07-28 | 2005-07-26 | Derivados de arilpiperazina sulfonamida como agonistas de los receptores de secretagogos de la hormona del crecimiento (ghs) |
Country Status (16)
Country | Link |
---|---|
US (1) | US7381728B2 (es) |
EP (1) | EP1778679A1 (es) |
JP (1) | JP2008508221A (es) |
KR (1) | KR20070041762A (es) |
AR (1) | AR053407A1 (es) |
AU (1) | AU2005266448A1 (es) |
BR (1) | BRPI0513713A (es) |
CA (1) | CA2575359A1 (es) |
IL (1) | IL180680A0 (es) |
MA (1) | MA28791B1 (es) |
MX (1) | MX2007001106A (es) |
NO (1) | NO20071138L (es) |
PE (1) | PE20060574A1 (es) |
RU (1) | RU2007107349A (es) |
TW (1) | TW200614987A (es) |
WO (1) | WO2006010629A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
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US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
BRPI0615934A2 (pt) * | 2005-09-16 | 2011-05-31 | Arrow Therapeutics Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, uso de um derivado de bifenila, composição farmacêutica, e, produto |
WO2007113202A1 (en) * | 2006-03-31 | 2007-10-11 | Glaxo Group Limited | Piperazine derivatives as growth hormone secretagogue (ghs) receptor agonists |
US20100179168A1 (en) * | 2006-04-13 | 2010-07-15 | Emma Louise Blaney | Aryl and heteroaryl sulphonamides as growth hormone secretagogue receptor agonists |
GB0617865D0 (en) * | 2006-09-11 | 2006-10-18 | Glaxo Group Ltd | Novel use |
JP5208963B2 (ja) | 2007-01-10 | 2013-06-12 | エフ.ホフマン−ラ ロシュ アーゲー | キマーゼ阻害剤としてのスルホンアミド誘導体 |
BRPI0807046A2 (pt) | 2007-02-09 | 2015-05-26 | Tranzyme Pharma Inc | Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit. |
GB0710865D0 (en) * | 2007-06-06 | 2007-07-18 | Glaxo Group Ltd | Novel compounds |
PA8802201A1 (es) * | 2007-11-02 | 2009-06-23 | Abbott Gmbh & Co Kg | Compuestos de bencensulfonalida apropiados para tratar trastornos que responden a la modulacion del receptor de serotonina 5-ht6 |
UA103319C2 (en) * | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
US8183237B2 (en) | 2009-04-30 | 2012-05-22 | Abbott Laboratories | Benzenesulfonanilide compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
EP2432769B1 (en) | 2009-04-30 | 2015-04-01 | AbbVie Deutschland GmbH & Co KG | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor |
US8343959B2 (en) | 2009-04-30 | 2013-01-01 | Abbott Gmbh & Co. Kg | N-phenyl-(piperazinyl or homopiperazinyl)-benzenesulfonamide or benzenesulfonyl-phenyl-(piperazine or homopiperazine) compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
WO2010125136A1 (en) | 2009-04-30 | 2010-11-04 | Abbott Gmbh & Co. Kg | Benzenesulfonanilide compounds suitable for treating disorders that respond to modulation of the serotonin 5-ht6 receptor |
JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体 |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
WO2011095450A1 (en) | 2010-02-02 | 2011-08-11 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
GB201002563D0 (en) | 2010-02-15 | 2010-03-31 | Cambridge Entpr Ltd | Compounds |
WO2012059432A1 (en) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor |
WO2012059431A1 (en) | 2010-11-01 | 2012-05-10 | Abbott Gmbh & Co. Kg | Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor |
CN104557896A (zh) * | 2013-10-18 | 2015-04-29 | 沈敬山 | 布瑞哌唑、其关键中间体及其盐的制备方法 |
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DE69417427T2 (de) | 1993-09-03 | 1999-11-25 | Smithkline Beecham P.L.C., Brentford | Indol- und indolin-derivate als 5ht1d rezeptor antagonisten |
TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
JP2002521377A (ja) | 1998-07-20 | 2002-07-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ビフェニル誘導体 |
CA2385737A1 (en) | 1999-09-25 | 2001-04-05 | Howard Marshall | Piperazine derivatives as 5-ht1b antagonists |
WO2001032660A1 (en) | 1999-11-05 | 2001-05-10 | Nps Allelix Corp. | Compounds having 5-ht6 receptor antagonist activity |
ES2333097T3 (es) | 2000-05-31 | 2010-02-17 | Raqualia Pharma Inc | Uso de secretagogos de la hormona de crecimiento para estimular la motilidad gastrointestinal. |
KR100822655B1 (ko) | 2000-11-02 | 2008-04-17 | 와이어쓰 | 5-하이드록시트립타민-6 리간드로서의 1-아릴설포닐- 또는 1-알킬설포닐-헤테로사이클릴벤즈아졸, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
GB0106419D0 (en) | 2001-03-15 | 2001-05-02 | Smithkline Beecham Plc | Novel compounds |
GB0106586D0 (en) | 2001-03-16 | 2001-05-09 | Smithkline Beecham Plc | Novel compounds |
GB0130705D0 (en) * | 2001-12-21 | 2002-02-06 | Glaxo Group Ltd | Chemical compounds |
US7319111B2 (en) * | 2003-02-20 | 2008-01-15 | Encysive Pharmaceuticals, Inc. | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists |
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2005
- 2005-07-26 BR BRPI0513713-6A patent/BRPI0513713A/pt not_active IP Right Cessation
- 2005-07-26 JP JP2007523024A patent/JP2008508221A/ja active Pending
- 2005-07-26 WO PCT/EP2005/008263 patent/WO2006010629A1/en active Application Filing
- 2005-07-26 US US11/572,715 patent/US7381728B2/en not_active Expired - Fee Related
- 2005-07-26 MX MX2007001106A patent/MX2007001106A/es not_active Application Discontinuation
- 2005-07-26 TW TW094125196A patent/TW200614987A/zh unknown
- 2005-07-26 KR KR1020077004797A patent/KR20070041762A/ko not_active Application Discontinuation
- 2005-07-26 AR ARP050103094A patent/AR053407A1/es not_active Application Discontinuation
- 2005-07-26 PE PE2005000873A patent/PE20060574A1/es not_active Application Discontinuation
- 2005-07-26 RU RU2007107349/04A patent/RU2007107349A/ru not_active Application Discontinuation
- 2005-07-26 EP EP05763645A patent/EP1778679A1/en not_active Withdrawn
- 2005-07-26 AU AU2005266448A patent/AU2005266448A1/en not_active Abandoned
- 2005-07-26 CA CA002575359A patent/CA2575359A1/en not_active Abandoned
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2007
- 2007-01-11 IL IL180680A patent/IL180680A0/en unknown
- 2007-02-06 MA MA29664A patent/MA28791B1/fr unknown
- 2007-02-28 NO NO20071138A patent/NO20071138L/no not_active Application Discontinuation
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US7381728B2 (en) | 2008-06-03 |
CA2575359A1 (en) | 2006-02-02 |
AR053407A1 (es) | 2007-05-09 |
JP2008508221A (ja) | 2008-03-21 |
BRPI0513713A (pt) | 2008-05-13 |
EP1778679A1 (en) | 2007-05-02 |
WO2006010629A1 (en) | 2006-02-02 |
KR20070041762A (ko) | 2007-04-19 |
US20070259877A1 (en) | 2007-11-08 |
RU2007107349A (ru) | 2008-09-10 |
TW200614987A (en) | 2006-05-16 |
NO20071138L (no) | 2007-02-28 |
AU2005266448A1 (en) | 2006-02-02 |
MA28791B1 (fr) | 2007-08-01 |
IL180680A0 (en) | 2007-06-03 |
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